FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136131935> ?p ?o ?g. }

• W3136131935 endingPage "1955" @default.
• W3136131935 startingPage "1937" @default.
• W3136131935 abstract "Abstract Purpose Dysregulated expression of proteoglycans influences the outcome and progression of numerous cancers. Several studies have investigated the role of individual glypicans in cancer, however, the impact of the whole glypican family of heparan sulfate proteoglycans on prognosis of a large patient cohort of breast cancer patients has not yet been investigated. In the present study, our aim was to investigate the prognostic power of the glypicans in breast cancer patients. Methods We used a public database including both gene expression data and survival information for 3951 breast cancer patients to determine the prognostic value of glypicans on relapse-free survival using Cox regression analysis. Moreover, we performed quantitative Real-Time PCR to determine glypican gene expression levels in seven representative breast cancer cell lines. Results We found that high GPC3 levels were associated with a better prognosis in overall breast cancer patients. When stratified by hormone receptor status, we found that in worse prognosis subtypes low GPC1 levels correlate with a longer relapse-free survival, and in more favorable subtypes low GPC6 was associated with longer survival. Conclusion Our study concludes that glypicans could act as subtype-specific biomarkers for the prognosis of breast cancer patients and sparks hope for future research on glypicans possibly eventually providing targets for the treatment of the disease." @default.
• W3136131935 created "2021-03-29" @default.
• W3136131935 creator A5006795722 @default.
• W3136131935 creator A5023340072 @default.
• W3136131935 creator A5034776080 @default.
• W3136131935 date "2021-03-19" @default.
• W3136131935 modified "2023-10-16" @default.
• W3136131935 title "Prognostic impact of the glypican family of heparan sulfate proteoglycans on the survival of breast cancer patients" @default.
• W3136131935 cites W1608252769 @default.
• W3136131935 cites W1796070797 @default.
• W3136131935 cites W1964828595 @default.
• W3136131935 cites W1972462861 @default.
• W3136131935 cites W1977543422 @default.
• W3136131935 cites W1987556027 @default.
• W3136131935 cites W1995456101 @default.
• W3136131935 cites W1997545186 @default.
• W3136131935 cites W1998526870 @default.
• W3136131935 cites W2000266878 @default.
• W3136131935 cites W2022124977 @default.
• W3136131935 cites W2041742398 @default.
• W3136131935 cites W2050895091 @default.
• W3136131935 cites W2056621404 @default.
• W3136131935 cites W2071635593 @default.
• W3136131935 cites W2079080508 @default.
• W3136131935 cites W2085934079 @default.
• W3136131935 cites W2092076185 @default.
• W3136131935 cites W2092180337 @default.
• W3136131935 cites W2097929013 @default.
• W3136131935 cites W2107400825 @default.
• W3136131935 cites W2125410856 @default.
• W3136131935 cites W2127057139 @default.
• W3136131935 cites W2152635758 @default.
• W3136131935 cites W2156692042 @default.
• W3136131935 cites W2157651810 @default.
• W3136131935 cites W2344628383 @default.
• W3136131935 cites W2413809012 @default.
• W3136131935 cites W2441351280 @default.
• W3136131935 cites W2486582984 @default.
• W3136131935 cites W2506800529 @default.
• W3136131935 cites W2531294657 @default.
• W3136131935 cites W2573530098 @default.
• W3136131935 cites W2593104572 @default.
• W3136131935 cites W2735308735 @default.
• W3136131935 cites W2754171246 @default.
• W3136131935 cites W2762388141 @default.
• W3136131935 cites W2771031544 @default.
• W3136131935 cites W2793560665 @default.
• W3136131935 cites W2800411426 @default.
• W3136131935 cites W2808293799 @default.
• W3136131935 cites W2808461195 @default.
• W3136131935 cites W2809029138 @default.
• W3136131935 cites W2809277839 @default.
• W3136131935 cites W2890624098 @default.
• W3136131935 cites W2892617983 @default.
• W3136131935 cites W2893622300 @default.
• W3136131935 cites W2899197140 @default.
• W3136131935 cites W2900569176 @default.
• W3136131935 cites W2912993657 @default.
• W3136131935 cites W2954910819 @default.
• W3136131935 cites W2962706882 @default.
• W3136131935 cites W2972319675 @default.
• W3136131935 cites W3011686964 @default.
• W3136131935 cites W3048449967 @default.
• W3136131935 cites W3094903561 @default.
• W3136131935 cites W3120955038 @default.
• W3136131935 cites W4241399562 @default.
• W3136131935 cites W4297745080 @default.
• W3136131935 doi "https://doi.org/10.1007/s00432-021-03597-4" @default.
• W3136131935 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8164625" @default.
• W3136131935 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33742285" @default.
• W3136131935 hasPublicationYear "2021" @default.
• W3136131935 type Work @default.
• W3136131935 sameAs 3136131935 @default.
• W3136131935 citedByCount "7" @default.
• W3136131935 countsByYear W31361319352022 @default.
• W3136131935 countsByYear W31361319352023 @default.
• W3136131935 crossrefType "journal-article" @default.
• W3136131935 hasAuthorship W3136131935A5006795722 @default.
• W3136131935 hasAuthorship W3136131935A5023340072 @default.
• W3136131935 hasAuthorship W3136131935A5034776080 @default.
• W3136131935 hasBestOaLocation W31361319351 @default.
• W3136131935 hasConcept C10515644 @default.
• W3136131935 hasConcept C121608353 @default.
• W3136131935 hasConcept C126322002 @default.
• W3136131935 hasConcept C143998085 @default.
• W3136131935 hasConcept C2779134260 @default.
• W3136131935 hasConcept C50382708 @default.
• W3136131935 hasConcept C530470458 @default.
• W3136131935 hasConcept C71924100 @default.
• W3136131935 hasConcept C72563966 @default.
• W3136131935 hasConceptScore W3136131935C10515644 @default.
• W3136131935 hasConceptScore W3136131935C121608353 @default.
• W3136131935 hasConceptScore W3136131935C126322002 @default.
• W3136131935 hasConceptScore W3136131935C143998085 @default.
• W3136131935 hasConceptScore W3136131935C2779134260 @default.
• W3136131935 hasConceptScore W3136131935C50382708 @default.
• W3136131935 hasConceptScore W3136131935C530470458 @default.
• W3136131935 hasConceptScore W3136131935C71924100 @default.

• next