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- W3136135789 endingPage "101230" @default.
- W3136135789 startingPage "101230" @default.
- W3136135789 abstract "Over the last 10 years, new techniques to administer surfactant have been promoted, based on their presumed lesser invasiveness and they have been generally called LISA (less invasive surfactant administration). We believe that the clinical potential of LISA techniques is currently overestimated. LISA lacks biological and pathophysiological background justifying its potential benefits. Moreover, LISA has been investigated in clinical trials without previous translational data and these trials are affected by significant flaws. The available data from these trials only allow to conclude that LISA is better than prolonged, unrestricted invasive ventilation with loosely described parameters, a mode of respiratory support that should be anyway avoided in preterm infants. We urge the conduction of high-quality studies to understand how to choose and titrate analgesia/sedation and optimize surfactant administration in preterm neonates. We offer a comprehensive, evidence-based review of the clinical data on LISA, their biases and the lack of physiopathology background." @default.
- W3136135789 created "2021-03-29" @default.
- W3136135789 creator A5035973300 @default.
- W3136135789 creator A5039444678 @default.
- W3136135789 creator A5086575273 @default.
- W3136135789 date "2021-04-01" @default.
- W3136135789 modified "2023-10-18" @default.
- W3136135789 title "LISA/MIST: Complex clinical problems almost never have easy solutions" @default.
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