FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136135933> ?p ?o ?g. }

• W3136135933 endingPage "571" @default.
• W3136135933 startingPage "563" @default.
• W3136135933 abstract "This study evaluated the potential use of senescence-inducing small molecules in the treatment of melanoma. We screened commercially available small-molecule libraries with high-throughput screening and high-content screening image-based technology. Our findings showed an initial hit with the embedded N-arylpiperidine-3-carboxamide scaffold-induced senescence-like phenotypic changes in human melanoma A375 cells without serious cytotoxicity against normal cells. A focused library containing diversely modified analogues were constructed and examined to evaluate the structure-activity relationship of N-arylpiperidine-3-carboxamide derivatives starting from hit 1. This work identified a novel compound with remarkable antiproliferative activity in vitro and demonstrated the key structural moieties within." @default.
• W3136135933 created "2021-03-29" @default.
• W3136135933 creator A5003590431 @default.
• W3136135933 creator A5004550953 @default.
• W3136135933 creator A5011504991 @default.
• W3136135933 creator A5038297631 @default.
• W3136135933 creator A5060617139 @default.
• W3136135933 creator A5061245630 @default.
• W3136135933 creator A5085207816 @default.
• W3136135933 creator A5088592090 @default.
• W3136135933 creator A5088724351 @default.
• W3136135933 date "2021-03-22" @default.
• W3136135933 modified "2023-10-17" @default.
• W3136135933 title "Identification of Piperidine-3-carboxamide Derivatives Inducing Senescence-like Phenotype with Antimelanoma Activities" @default.
• W3136135933 cites W1963842583 @default.
• W3136135933 cites W1977400158 @default.
• W3136135933 cites W1982361636 @default.
• W3136135933 cites W1984484299 @default.
• W3136135933 cites W1988936955 @default.
• W3136135933 cites W2004273407 @default.
• W3136135933 cites W2019727879 @default.
• W3136135933 cites W2038475839 @default.
• W3136135933 cites W2042140414 @default.
• W3136135933 cites W2044832154 @default.
• W3136135933 cites W2077450385 @default.
• W3136135933 cites W2077475477 @default.
• W3136135933 cites W2108482850 @default.
• W3136135933 cites W2116437342 @default.
• W3136135933 cites W2136380412 @default.
• W3136135933 cites W2137617661 @default.
• W3136135933 cites W2150735490 @default.
• W3136135933 cites W2162981791 @default.
• W3136135933 cites W2165460647 @default.
• W3136135933 cites W2166414346 @default.
• W3136135933 cites W2166732620 @default.
• W3136135933 cites W2210634983 @default.
• W3136135933 cites W2219817965 @default.
• W3136135933 cites W2319232270 @default.
• W3136135933 cites W2903003302 @default.
• W3136135933 cites W2913103261 @default.
• W3136135933 cites W3029435888 @default.
• W3136135933 cites W3043717319 @default.
• W3136135933 cites W4210433744 @default.
• W3136135933 doi "https://doi.org/10.1021/acsmedchemlett.0c00570" @default.
• W3136135933 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8040044" @default.
• W3136135933 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33859796" @default.
• W3136135933 hasPublicationYear "2021" @default.
• W3136135933 type Work @default.
• W3136135933 sameAs 3136135933 @default.
• W3136135933 citedByCount "3" @default.
• W3136135933 countsByYear W31361359332022 @default.
• W3136135933 countsByYear W31361359332023 @default.
• W3136135933 crossrefType "journal-article" @default.
• W3136135933 hasAuthorship W3136135933A5003590431 @default.
• W3136135933 hasAuthorship W3136135933A5004550953 @default.
• W3136135933 hasAuthorship W3136135933A5011504991 @default.
• W3136135933 hasAuthorship W3136135933A5038297631 @default.
• W3136135933 hasAuthorship W3136135933A5060617139 @default.
• W3136135933 hasAuthorship W3136135933A5061245630 @default.
• W3136135933 hasAuthorship W3136135933A5085207816 @default.
• W3136135933 hasAuthorship W3136135933A5088592090 @default.
• W3136135933 hasAuthorship W3136135933A5088724351 @default.
• W3136135933 hasBestOaLocation W31361359332 @default.
• W3136135933 hasConcept C104317684 @default.
• W3136135933 hasConcept C109316439 @default.
• W3136135933 hasConcept C116834253 @default.
• W3136135933 hasConcept C127716648 @default.
• W3136135933 hasConcept C1491633281 @default.
• W3136135933 hasConcept C157044486 @default.
• W3136135933 hasConcept C161624437 @default.
• W3136135933 hasConcept C185592680 @default.
• W3136135933 hasConcept C202751555 @default.
• W3136135933 hasConcept C2777658100 @default.
• W3136135933 hasConcept C2778327999 @default.
• W3136135933 hasConcept C2781462491 @default.
• W3136135933 hasConcept C502942594 @default.
• W3136135933 hasConcept C522857546 @default.
• W3136135933 hasConcept C55493867 @default.
• W3136135933 hasConcept C59822182 @default.
• W3136135933 hasConcept C6555983 @default.
• W3136135933 hasConcept C70721500 @default.
• W3136135933 hasConcept C71240020 @default.
• W3136135933 hasConcept C71924100 @default.
• W3136135933 hasConcept C86803240 @default.
• W3136135933 hasConcept C95444343 @default.
• W3136135933 hasConcept C98274493 @default.
• W3136135933 hasConceptScore W3136135933C104317684 @default.
• W3136135933 hasConceptScore W3136135933C109316439 @default.
• W3136135933 hasConceptScore W3136135933C116834253 @default.
• W3136135933 hasConceptScore W3136135933C127716648 @default.
• W3136135933 hasConceptScore W3136135933C1491633281 @default.
• W3136135933 hasConceptScore W3136135933C157044486 @default.
• W3136135933 hasConceptScore W3136135933C161624437 @default.
• W3136135933 hasConceptScore W3136135933C185592680 @default.
• W3136135933 hasConceptScore W3136135933C202751555 @default.
• W3136135933 hasConceptScore W3136135933C2777658100 @default.
• W3136135933 hasConceptScore W3136135933C2778327999 @default.
• W3136135933 hasConceptScore W3136135933C2781462491 @default.

• next