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- W3136142637 abstract "The voltage-dependent anion channel (VDAC) is the major pathway for metabolites and ions transport through the mitochondrial outer membrane. It can regulate the flow of solutes by switching to a low conductance state correlated with a selectivity reversal, or by a selectivity inversion of its open state. The later one was observed in non-plant VDACs and is poorly characterized. We aim at investigating the selectivity inversion of the open state using plant VDAC purified from Phaseolus coccineus (PcVDAC) to evaluate its physiological role. Our main findings are: (1) The VDAC selectivity inversion of the open state occurs in PcVDAC, (2) Ion concentration and stigmasterol affect the occurrence of the open state selectivity inversion and stigmasterol appears to interact directly with PcVDAC. Interestingly, electrophysiological data concerning the selectivity inversion of the PcVDAC open state suggests that the phenomenon probably does not have a significant physiological effect in vivo." @default.
- W3136142637 created "2021-03-29" @default.
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- W3136142637 date "2021-03-16" @default.
- W3136142637 modified "2023-09-26" @default.
- W3136142637 title "The Open State Selectivity of the Bean Seed VDAC Depends on Stigmasterol and Ion Concentration" @default.
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- W3136142637 doi "https://doi.org/10.3390/ijms22063034" @default.
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