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• W3136142968 abstract "Abstract Recombination of short DNA fragments via horizontal gene transfer (HGT) can both introduce beneficial alleles and create disharmony in coadapted genomes (negative epistasis). Owing to a lack of protracted intragenomic co-evolution, negative epistatic costs of HGT into non-core (accessory) bacterial genomes are likely to be minimal. By contrast, for the core genome, recombination is expected to be rare because disruptive allelic replacement is likely to introduce negative epistasis. Why then is homologous recombination common in the core of bacterial genomes? To understand this enigma, we take advantage of an exceptional model system, the common enteric pathogens Campylobacter jejuni and Campylobacter coli , that are known for very high magnitude interspecies gene flow in the core genome. As expected, HGT does indeed disrupt co-adapted allele pairings (negative epistasis). However, multiple HGT events enable recovery of the recipient genome’s co-adaption between the alleles, even in core metabolism genes (e.g. formate dehydrogenase). These findings demonstrate that, even for complex traits, genetic coalitions can be decoupled, transferred and independently reinstated in a new genetic background. There is a strong resemblance to the two-hit cancer model. Whether it be by multiple mutations or multiple HGT events, immediate harmful effects from an initial event need not preclude adaptive evolution. The fitness peak jumping problem in asexual lineages is thus less of problem than envisaged." @default.
• W3136142968 created "2021-03-29" @default.
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• W3136142968 date "2021-03-15" @default.
• W3136142968 modified "2023-10-18" @default.
• W3136142968 title "Cross-species evolutionary rewiring in the enteric bacteriumCampylobacter" @default.
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• W3136142968 cites W1977060309 @default.
• W3136142968 cites W1983885533 @default.
• W3136142968 cites W2000769542 @default.
• W3136142968 cites W2004548026 @default.
• W3136142968 cites W2007688114 @default.
• W3136142968 cites W2017968564 @default.
• W3136142968 cites W2025021478 @default.
• W3136142968 cites W2026232375 @default.
• W3136142968 cites W2031611770 @default.
• W3136142968 cites W2032237557 @default.
• W3136142968 cites W2034890237 @default.
• W3136142968 cites W2040322059 @default.
• W3136142968 cites W2053940732 @default.
• W3136142968 cites W2059542829 @default.
• W3136142968 cites W2074014006 @default.
• W3136142968 cites W2075168677 @default.
• W3136142968 cites W2075378012 @default.
• W3136142968 cites W2077858999 @default.
• W3136142968 cites W2078420554 @default.
• W3136142968 cites W2079778505 @default.
• W3136142968 cites W2080873675 @default.
• W3136142968 cites W2083187008 @default.
• W3136142968 cites W2083539954 @default.
• W3136142968 cites W2088021925 @default.
• W3136142968 cites W2093917326 @default.
• W3136142968 cites W2095800942 @default.
• W3136142968 cites W2104367488 @default.
• W3136142968 cites W2107678755 @default.
• W3136142968 cites W2110040181 @default.
• W3136142968 cites W2111211467 @default.
• W3136142968 cites W2116433671 @default.
• W3136142968 cites W2120902911 @default.
• W3136142968 cites W2121166240 @default.
• W3136142968 cites W2125302790 @default.
• W3136142968 cites W2130550301 @default.
• W3136142968 cites W2130621427 @default.
• W3136142968 cites W2135667219 @default.
• W3136142968 cites W2138952930 @default.
• W3136142968 cites W2141467712 @default.
• W3136142968 cites W2146700947 @default.
• W3136142968 cites W2154592057 @default.
• W3136142968 cites W2155053954 @default.
• W3136142968 cites W2156173835 @default.
• W3136142968 cites W2160088726 @default.
• W3136142968 cites W2162455852 @default.
• W3136142968 cites W2163320297 @default.
• W3136142968 cites W2303043072 @default.
• W3136142968 cites W2554059947 @default.
• W3136142968 cites W2587392017 @default.
• W3136142968 cites W2589461950 @default.
• W3136142968 cites W2602439962 @default.
• W3136142968 cites W2608079295 @default.
• W3136142968 cites W2767681553 @default.
• W3136142968 cites W2768240280 @default.
• W3136142968 cites W2769555044 @default.
• W3136142968 cites W2809878000 @default.
• W3136142968 cites W2921833612 @default.
• W3136142968 cites W2950675215 @default.
• W3136142968 cites W2952473089 @default.
• W3136142968 cites W3021729976 @default.
• W3136142968 cites W3048728347 @default.
• W3136142968 cites W3119366910 @default.
• W3136142968 cites W3201697337 @default.
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• W3136142968 doi "https://doi.org/10.1101/2021.03.15.435406" @default.
• W3136142968 hasPublicationYear "2021" @default.
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