FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136143500> ?p ?o ?g. }

• W3136143500 abstract "In recent years, individual and collective human intelligence, defined as the knowledge, skills, reasoning and intuition of individuals and groups, have been used in combination with computer algorithms to solve complex scientific problems. Such approach was successfully used in different research fields such as: structural biology, comparative genomics, macromolecular crystallography and RNA design. Herein we describe an attempt to use a similar approach in small-molecule drug discovery, specifically to drive search strategies of de novo drug design. This is assessed with a case study that consists of a series of public experiments in which participants had to explore the huge chemical space in silico to find predefined compounds by designing molecules and analyzing the score associate with them. Such a process may be seen as an instantaneous surrogate of the classical design-make-test cycles carried out by medicinal chemists during the drug discovery hit to lead phase but not hindered by long synthesis and testing times. We present first findings on (1) assessing human intelligence in chemical space exploration, (2) comparing individual and collective human intelligence performance in this task and (3) contrasting some human and artificial intelligence achievements in de novo drug design." @default.
• W3136143500 created "2021-03-29" @default.
• W3136143500 creator A5038855105 @default.
• W3136143500 creator A5053178382 @default.
• W3136143500 creator A5083021665 @default.
• W3136143500 date "2021-10-11" @default.
• W3136143500 modified "2023-09-25" @default.
• W3136143500 title "Individual and collective human intelligence in drug design: evaluating the search strategy" @default.
• W3136143500 cites W1508604947 @default.
• W3136143500 cites W1509196567 @default.
• W3136143500 cites W1528242634 @default.
• W3136143500 cites W1714211023 @default.
• W3136143500 cites W1967656209 @default.
• W3136143500 cites W1975147762 @default.
• W3136143500 cites W1975875968 @default.
• W3136143500 cites W1986176168 @default.
• W3136143500 cites W1988037271 @default.
• W3136143500 cites W1992145496 @default.
• W3136143500 cites W1992156271 @default.
• W3136143500 cites W2003209620 @default.
• W3136143500 cites W2009605433 @default.
• W3136143500 cites W2010328851 @default.
• W3136143500 cites W2011230643 @default.
• W3136143500 cites W2017254234 @default.
• W3136143500 cites W2023818227 @default.
• W3136143500 cites W2027478081 @default.
• W3136143500 cites W2038617772 @default.
• W3136143500 cites W2038702914 @default.
• W3136143500 cites W2043284163 @default.
• W3136143500 cites W2051741744 @default.
• W3136143500 cites W2060531713 @default.
• W3136143500 cites W2064675550 @default.
• W3136143500 cites W2065628532 @default.
• W3136143500 cites W2073338313 @default.
• W3136143500 cites W2075028158 @default.
• W3136143500 cites W2087642222 @default.
• W3136143500 cites W2092568776 @default.
• W3136143500 cites W2096541451 @default.
• W3136143500 cites W2097790371 @default.
• W3136143500 cites W2107160601 @default.
• W3136143500 cites W2108021950 @default.
• W3136143500 cites W2110791536 @default.
• W3136143500 cites W2114704115 @default.
• W3136143500 cites W2148797284 @default.
• W3136143500 cites W2151697120 @default.
• W3136143500 cites W2152320247 @default.
• W3136143500 cites W2153861051 @default.
• W3136143500 cites W2161782568 @default.
• W3136143500 cites W2206840988 @default.
• W3136143500 cites W2275489486 @default.
• W3136143500 cites W2410045955 @default.
• W3136143500 cites W2476452061 @default.
• W3136143500 cites W2519080286 @default.
• W3136143500 cites W2558999090 @default.
• W3136143500 cites W2578240541 @default.
• W3136143500 cites W2622236128 @default.
• W3136143500 cites W2763220183 @default.
• W3136143500 cites W2773785180 @default.
• W3136143500 cites W2883583109 @default.
• W3136143500 cites W2889555425 @default.
• W3136143500 cites W2900090807 @default.
• W3136143500 cites W2914542247 @default.
• W3136143500 cites W2948671659 @default.
• W3136143500 cites W2953128081 @default.
• W3136143500 cites W2956076207 @default.
• W3136143500 cites W3087206849 @default.
• W3136143500 cites W3098269892 @default.
• W3136143500 cites W3100751385 @default.
• W3136143500 cites W3100839802 @default.
• W3136143500 cites W4236386651 @default.
• W3136143500 cites W959778778 @default.
• W3136143500 doi "https://doi.org/10.1186/s13321-021-00556-6" @default.
• W3136143500 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8507178" @default.
• W3136143500 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34635158" @default.
• W3136143500 hasPublicationYear "2021" @default.
• W3136143500 type Work @default.
• W3136143500 sameAs 3136143500 @default.
• W3136143500 citedByCount "2" @default.
• W3136143500 countsByYear W31361435002022 @default.
• W3136143500 crossrefType "journal-article" @default.
• W3136143500 hasAuthorship W3136143500A5038855105 @default.
• W3136143500 hasAuthorship W3136143500A5053178382 @default.
• W3136143500 hasAuthorship W3136143500A5083021665 @default.
• W3136143500 hasBestOaLocation W31361435001 @default.
• W3136143500 hasConcept C105409693 @default.
• W3136143500 hasConcept C111919701 @default.
• W3136143500 hasConcept C127413603 @default.
• W3136143500 hasConcept C132010649 @default.
• W3136143500 hasConcept C154945302 @default.
• W3136143500 hasConcept C15744967 @default.
• W3136143500 hasConcept C188147891 @default.
• W3136143500 hasConcept C201995342 @default.
• W3136143500 hasConcept C2522767166 @default.
• W3136143500 hasConcept C2780451532 @default.
• W3136143500 hasConcept C41008148 @default.
• W3136143500 hasConcept C60644358 @default.
• W3136143500 hasConcept C74187038 @default.
• W3136143500 hasConcept C86803240 @default.
• W3136143500 hasConcept C89057211 @default.
• W3136143500 hasConcept C98045186 @default.

• next