Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136144723> ?p ?o ?g. }
- W3136144723 endingPage "232" @default.
- W3136144723 startingPage "218" @default.
- W3136144723 abstract "The objective of this study was to develop dermal nanosuspension (NS) based gel formulation of etodolac (ETD).Etodolac nanosuspension (ETD-NS) was prepared by wet milling method and dispersed in hydroxypropyl methylcellulose (NS-HPMC) or hydroxyethyl cellulose (NS-HEC) gels. Rheologic and mechanical properties were investigated. In vitro and ex vivo permeability studies were performed. Topical anti-inflammatory and analgesic activity were evaluated in regard to carrageenan-induced inflammatory paw oedema and radiant heat tail-flick method, respectively.The ETD-NS with approximately 190 nm particle size (PS), 0.16 polydispersity index (PDI), and -15 mV zeta potential (ZP) values were obtained. The work of bioadhesion values of NS-HEC and NS-HPMC gels were 0.229 mJ/cm2 for both gels. Dermal permeation of ETD from NS-HEC gel (7.18%) was found significantly higher than the NS-HPMC gel (4.56%). Enhanced anti-inflammatory and analgesic activity of NS-HEC gels were observed in comparison with micronised ETD.ETD-NS based gel formulation is promising for topical delivery of ETD." @default.
- W3136144723 created "2021-03-29" @default.
- W3136144723 creator A5017910635 @default.
- W3136144723 creator A5026774195 @default.
- W3136144723 creator A5071406385 @default.
- W3136144723 creator A5076842560 @default.
- W3136144723 creator A5077675879 @default.
- W3136144723 date "2021-03-23" @default.
- W3136144723 modified "2023-09-26" @default.
- W3136144723 title "Etodolac nanosuspension based gel for enhanced dermal delivery: <i>in vitro</i> and <i>in vivo</i> evaluation" @default.
- W3136144723 cites W1503601397 @default.
- W3136144723 cites W1585026215 @default.
- W3136144723 cites W1934616509 @default.
- W3136144723 cites W1970652854 @default.
- W3136144723 cites W1974646909 @default.
- W3136144723 cites W1992818133 @default.
- W3136144723 cites W2000534575 @default.
- W3136144723 cites W2003381711 @default.
- W3136144723 cites W2016039726 @default.
- W3136144723 cites W2025498933 @default.
- W3136144723 cites W2026930707 @default.
- W3136144723 cites W2031727690 @default.
- W3136144723 cites W2032260361 @default.
- W3136144723 cites W2040935344 @default.
- W3136144723 cites W2054260281 @default.
- W3136144723 cites W2054866798 @default.
- W3136144723 cites W2055903916 @default.
- W3136144723 cites W2062143336 @default.
- W3136144723 cites W2073863607 @default.
- W3136144723 cites W2074630757 @default.
- W3136144723 cites W2083056135 @default.
- W3136144723 cites W2083995456 @default.
- W3136144723 cites W2085787108 @default.
- W3136144723 cites W2112557421 @default.
- W3136144723 cites W2132947775 @default.
- W3136144723 cites W2156407047 @default.
- W3136144723 cites W2280043506 @default.
- W3136144723 cites W2282362572 @default.
- W3136144723 cites W2290937619 @default.
- W3136144723 cites W2330681932 @default.
- W3136144723 cites W2338485359 @default.
- W3136144723 cites W2401096894 @default.
- W3136144723 cites W242207394 @default.
- W3136144723 cites W2469892682 @default.
- W3136144723 cites W2507673555 @default.
- W3136144723 cites W2518969719 @default.
- W3136144723 cites W2594370429 @default.
- W3136144723 cites W2600955181 @default.
- W3136144723 cites W2606369211 @default.
- W3136144723 cites W2619002091 @default.
- W3136144723 cites W2752308853 @default.
- W3136144723 cites W2752521403 @default.
- W3136144723 cites W2755472537 @default.
- W3136144723 cites W2764309481 @default.
- W3136144723 cites W2766425019 @default.
- W3136144723 cites W2767334105 @default.
- W3136144723 cites W2792793009 @default.
- W3136144723 cites W2811163685 @default.
- W3136144723 cites W2914309733 @default.
- W3136144723 cites W2922490738 @default.
- W3136144723 cites W2937789812 @default.
- W3136144723 cites W2955688288 @default.
- W3136144723 cites W2961825790 @default.
- W3136144723 cites W2973877898 @default.
- W3136144723 cites W2994754435 @default.
- W3136144723 cites W2996869513 @default.
- W3136144723 cites W3005782155 @default.
- W3136144723 cites W3007071961 @default.
- W3136144723 cites W3013062704 @default.
- W3136144723 cites W3029427507 @default.
- W3136144723 cites W3120143349 @default.
- W3136144723 doi "https://doi.org/10.1080/02652048.2021.1895344" @default.
- W3136144723 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33752553" @default.
- W3136144723 hasPublicationYear "2021" @default.
- W3136144723 type Work @default.
- W3136144723 sameAs 3136144723 @default.
- W3136144723 citedByCount "9" @default.
- W3136144723 countsByYear W31361447232022 @default.
- W3136144723 countsByYear W31361447232023 @default.
- W3136144723 crossrefType "journal-article" @default.
- W3136144723 hasAuthorship W3136144723A5017910635 @default.
- W3136144723 hasAuthorship W3136144723A5026774195 @default.
- W3136144723 hasAuthorship W3136144723A5071406385 @default.
- W3136144723 hasAuthorship W3136144723A5076842560 @default.
- W3136144723 hasAuthorship W3136144723A5077675879 @default.
- W3136144723 hasConcept C11432220 @default.
- W3136144723 hasConcept C147789679 @default.
- W3136144723 hasConcept C150903083 @default.
- W3136144723 hasConcept C155672457 @default.
- W3136144723 hasConcept C171250308 @default.
- W3136144723 hasConcept C178790620 @default.
- W3136144723 hasConcept C185592680 @default.
- W3136144723 hasConcept C187530423 @default.
- W3136144723 hasConcept C188027245 @default.
- W3136144723 hasConcept C192562407 @default.
- W3136144723 hasConcept C207001950 @default.
- W3136144723 hasConcept C2776174307 @default.
- W3136144723 hasConcept C2776634624 @default.