FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136146723> ?p ?o ?g. }

• W3136146723 endingPage "383" @default.
• W3136146723 startingPage "377" @default.
• W3136146723 abstract "Bitter melon (Momordica charantia L.) has been shown to have various health-promoting activities, including antidiabetic and hypoglycaemic effects. Improvement in insulin sensitivity and increase in glucose utilisation in peripheral tissues have been reported, but the effect on insulin secretion from pancreatic β-cells remains unclear. In this study, we investigated the effect of bitter melon fruit on insulin secretion from β-cells and the underlying mechanism. The green fruit of bitter melon was freeze-dried and extracted with methanol. The bitter melon fruit extract (BMFE) was fractionated using ethyl acetate (fraction A), n-butanol (fraction B) and water (fraction C). Insulin secretory capacity from INS-1 rat insulinoma cell line and rat pancreatic islets, as well as glucose tolerance in rats by oral glucose tolerance test (OGTT), was measured using BMFE and fractions. ATP production in β-cells was also examined. BMFE augmented insulin secretion from INS-1 cells in a dose-dependent manner. The significant augmentation of insulin secretion was independent of the glucose dose. Fraction A (i.e. hydrophobic fraction), but not fractions B and C, augmented insulin secretion significantly at the same level as that by BMFE. This finding was also observed in pancreatic islets. In OGTT, BMFE and fraction A decreased blood glucose levels and increased serum insulin levels after glucose loading. The decrease in blood glucose levels was also observed in streptozotocin-induced diabetic rats. In addition, BMFE and fraction A increased the ATP content in β-cells. We concluded that hydrophobic components of BMFE increase ATP production and augment insulin secretion from β-cells, consequently decreasing blood glucose levels." @default.
• W3136146723 created "2021-03-29" @default.
• W3136146723 creator A5010151099 @default.
• W3136146723 creator A5017004865 @default.
• W3136146723 creator A5027308917 @default.
• W3136146723 creator A5035657922 @default.
• W3136146723 creator A5077190042 @default.
• W3136146723 creator A5079577951 @default.
• W3136146723 creator A5079800462 @default.
• W3136146723 creator A5091507685 @default.
• W3136146723 date "2021-03-25" @default.
• W3136146723 modified "2023-10-10" @default.
• W3136146723 title "Bitter melon fruit extract enhances intracellular ATP production and insulin secretion from rat pancreatic <i>β</i>-cells" @default.
• W3136146723 cites W1944521216 @default.
• W3136146723 cites W1981912710 @default.
• W3136146723 cites W1987287476 @default.
• W3136146723 cites W2009988510 @default.
• W3136146723 cites W2014066468 @default.
• W3136146723 cites W2014097482 @default.
• W3136146723 cites W2019768606 @default.
• W3136146723 cites W2027014275 @default.
• W3136146723 cites W2030845275 @default.
• W3136146723 cites W2055791664 @default.
• W3136146723 cites W2062494428 @default.
• W3136146723 cites W2065423457 @default.
• W3136146723 cites W2080860314 @default.
• W3136146723 cites W2113842221 @default.
• W3136146723 cites W2142869757 @default.
• W3136146723 cites W2145661125 @default.
• W3136146723 cites W2150464859 @default.
• W3136146723 cites W2153939223 @default.
• W3136146723 cites W2594201864 @default.
• W3136146723 cites W2751070681 @default.
• W3136146723 cites W2769874622 @default.
• W3136146723 cites W2912721254 @default.
• W3136146723 cites W2918023256 @default.
• W3136146723 cites W2996366056 @default.
• W3136146723 cites W4241385366 @default.
• W3136146723 cites W963133441 @default.
• W3136146723 doi "https://doi.org/10.1017/s0007114521001082" @default.
• W3136146723 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33762029" @default.
• W3136146723 hasPublicationYear "2021" @default.
• W3136146723 type Work @default.
• W3136146723 sameAs 3136146723 @default.
• W3136146723 citedByCount "4" @default.
• W3136146723 countsByYear W31361467232022 @default.
• W3136146723 countsByYear W31361467232023 @default.
• W3136146723 crossrefType "journal-article" @default.
• W3136146723 hasAuthorship W3136146723A5010151099 @default.
• W3136146723 hasAuthorship W3136146723A5017004865 @default.
• W3136146723 hasAuthorship W3136146723A5027308917 @default.
• W3136146723 hasAuthorship W3136146723A5035657922 @default.
• W3136146723 hasAuthorship W3136146723A5077190042 @default.
• W3136146723 hasAuthorship W3136146723A5079577951 @default.
• W3136146723 hasAuthorship W3136146723A5079800462 @default.
• W3136146723 hasAuthorship W3136146723A5091507685 @default.
• W3136146723 hasBestOaLocation W31361467231 @default.
• W3136146723 hasConcept C126322002 @default.
• W3136146723 hasConcept C134018914 @default.
• W3136146723 hasConcept C165220095 @default.
• W3136146723 hasConcept C185592680 @default.
• W3136146723 hasConcept C2779306644 @default.
• W3136146723 hasConcept C2779855799 @default.
• W3136146723 hasConcept C2780053029 @default.
• W3136146723 hasConcept C49039625 @default.
• W3136146723 hasConcept C55493867 @default.
• W3136146723 hasConcept C555293320 @default.
• W3136146723 hasConcept C71924100 @default.
• W3136146723 hasConcept C79879829 @default.
• W3136146723 hasConcept C86803240 @default.
• W3136146723 hasConceptScore W3136146723C126322002 @default.
• W3136146723 hasConceptScore W3136146723C134018914 @default.
• W3136146723 hasConceptScore W3136146723C165220095 @default.
• W3136146723 hasConceptScore W3136146723C185592680 @default.
• W3136146723 hasConceptScore W3136146723C2779306644 @default.
• W3136146723 hasConceptScore W3136146723C2779855799 @default.
• W3136146723 hasConceptScore W3136146723C2780053029 @default.
• W3136146723 hasConceptScore W3136146723C49039625 @default.
• W3136146723 hasConceptScore W3136146723C55493867 @default.
• W3136146723 hasConceptScore W3136146723C555293320 @default.
• W3136146723 hasConceptScore W3136146723C71924100 @default.
• W3136146723 hasConceptScore W3136146723C79879829 @default.
• W3136146723 hasConceptScore W3136146723C86803240 @default.
• W3136146723 hasIssue "3" @default.
• W3136146723 hasLocation W31361467231 @default.
• W3136146723 hasLocation W31361467232 @default.
• W3136146723 hasOpenAccess W3136146723 @default.
• W3136146723 hasPrimaryLocation W31361467231 @default.
• W3136146723 hasRelatedWork W1951162574 @default.
• W3136146723 hasRelatedWork W1968488515 @default.
• W3136146723 hasRelatedWork W1971124140 @default.
• W3136146723 hasRelatedWork W1985965417 @default.
• W3136146723 hasRelatedWork W1986182337 @default.
• W3136146723 hasRelatedWork W1986775667 @default.
• W3136146723 hasRelatedWork W2058006332 @default.
• W3136146723 hasRelatedWork W2064538767 @default.
• W3136146723 hasRelatedWork W2071871778 @default.
• W3136146723 hasRelatedWork W2328188075 @default.

• next