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• W3136146790 endingPage "202" @default.
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• W3136146790 abstract "Emerging evidence indicates an important role for neuroinflammation in depression. Brief maternal separation promotes resilience to depression in offspring, but relatively little is known about the effects of different durations of postpartum separation (PS) from offspring on anxiety and depressive-like behaviors in dams following immune challenge. Lactating C57BL/6J mice were subjected to no separation (NPS), brief PS (15 min/day, PS15) or prolonged PS (180 min/day, PS180) from postpartum day (PPD) 1 to PPD21 and then injected with lipopolysaccharide (LPS). Behavioral tests, including the open field test (OFT) and forced swimming test (FST), were carried out at 24 h after the injection. LPS resulted in anxiety and depressive-like behaviors in NPS dams and activated ionized calcium-binding adaptor molecule (Iba1), an important biomarker of microglia, in the hippocampus. However, compared with NPS + LPS dams, PS15 + LPS dams spent significantly more time in the center of the OFT (anxiety-like behavior) and exhibited lower immobility time in the FST (depressive-like behavior), which indicated a phenomenon of resilience. Furthermore, the activation of neuroinflammation was inhibited in PS15 dams. Specifically, levels of the Iba1 mRNA and protein were decreased, while the mRNA expression of NLR family pyrin domain containing 3 (NLRP3) inflammasome/interleukin-18 (IL-18)/nuclear factor kappa-B (NF-κB) was decreased in the hippocampus. Furthermore, positive linear correlations were observed between microglial activation and LPS-induced depressive-like behaviors in dams. Collectively, the findings of this study confirm that brief PS from offspring promotes resilience to LPS immune challenge-induced behavioral deficits and inhibits neuroinflammation in dams separated from their offspring during lactation." @default.
• W3136146790 created "2021-03-29" @default.
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• W3136146790 date "2021-07-01" @default.
• W3136146790 modified "2023-09-24" @default.
• W3136146790 title "Brief postpartum separation from offspring promotes resilience to lipopolysaccharide challenge-induced anxiety and depressive-like behaviors and inhibits neuroinflammation in C57BL/6J dams" @default.
• W3136146790 cites W1966757737 @default.
• W3136146790 cites W1971167579 @default.
• W3136146790 cites W1972391099 @default.
• W3136146790 cites W1988070297 @default.
• W3136146790 cites W2000907886 @default.
• W3136146790 cites W2003070777 @default.
• W3136146790 cites W2004205608 @default.
• W3136146790 cites W2010393216 @default.
• W3136146790 cites W2011081879 @default.
• W3136146790 cites W2013309206 @default.
• W3136146790 cites W2024959702 @default.
• W3136146790 cites W2032596805 @default.
• W3136146790 cites W2034355214 @default.
• W3136146790 cites W2037276809 @default.
• W3136146790 cites W2050508296 @default.
• W3136146790 cites W2057017838 @default.
• W3136146790 cites W2057200138 @default.
• W3136146790 cites W2059139697 @default.
• W3136146790 cites W2059555201 @default.
• W3136146790 cites W2061730652 @default.
• W3136146790 cites W2062917699 @default.
• W3136146790 cites W2072401753 @default.
• W3136146790 cites W2077192309 @default.
• W3136146790 cites W2077755718 @default.
• W3136146790 cites W2083048709 @default.
• W3136146790 cites W2086213088 @default.
• W3136146790 cites W2106623141 @default.
• W3136146790 cites W2114921087 @default.
• W3136146790 cites W2117309811 @default.
• W3136146790 cites W2135201319 @default.
• W3136146790 cites W2144101679 @default.
• W3136146790 cites W2152958471 @default.
• W3136146790 cites W2163419000 @default.
• W3136146790 cites W2164333066 @default.
• W3136146790 cites W2168736678 @default.
• W3136146790 cites W2271686560 @default.
• W3136146790 cites W2333008150 @default.
• W3136146790 cites W2344574529 @default.
• W3136146790 cites W2404523827 @default.
• W3136146790 cites W2416643466 @default.
• W3136146790 cites W2428176893 @default.
• W3136146790 cites W2490331232 @default.
• W3136146790 cites W2519531315 @default.
• W3136146790 cites W2559769511 @default.
• W3136146790 cites W2559937348 @default.
• W3136146790 cites W2581908356 @default.
• W3136146790 cites W2596169047 @default.
• W3136146790 cites W2611232393 @default.
• W3136146790 cites W2618584891 @default.
• W3136146790 cites W2755329196 @default.
• W3136146790 cites W2760332554 @default.
• W3136146790 cites W2766129136 @default.
• W3136146790 cites W2766449818 @default.
• W3136146790 cites W2770257940 @default.
• W3136146790 cites W2771367031 @default.
• W3136146790 cites W2800603098 @default.
• W3136146790 cites W2801261091 @default.
• W3136146790 cites W2803921579 @default.
• W3136146790 cites W2886190173 @default.
• W3136146790 cites W2888200105 @default.
• W3136146790 cites W2889334837 @default.
• W3136146790 cites W2889954108 @default.
• W3136146790 cites W2890670389 @default.
• W3136146790 cites W2897559249 @default.
• W3136146790 cites W2898314619 @default.
• W3136146790 cites W2905455133 @default.
• W3136146790 cites W2914543137 @default.
• W3136146790 cites W2916226351 @default.
• W3136146790 cites W2921576925 @default.
• W3136146790 cites W2938800717 @default.
• W3136146790 cites W2943357614 @default.
• W3136146790 cites W2945784511 @default.
• W3136146790 cites W2947067356 @default.
• W3136146790 cites W2952949941 @default.
• W3136146790 cites W2960015172 @default.
• W3136146790 cites W2963540498 @default.
• W3136146790 cites W2965970323 @default.
• W3136146790 cites W2966853871 @default.
• W3136146790 cites W2969423889 @default.
• W3136146790 cites W2983338165 @default.
• W3136146790 cites W2986023816 @default.
• W3136146790 cites W3000569588 @default.
• W3136146790 cites W3012588800 @default.
• W3136146790 cites W3023500558 @default.
• W3136146790 cites W3025918268 @default.
• W3136146790 cites W3032793454 @default.

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