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- W3136149334 abstract "• MERTK gene was silenced in H9 hESC cells using CRISPR/Cas9 system with dual sgRNAs.. • The subline was karyotyped and characterized. • Expression of SC markers and the ability of trilineage differentiation was verified. • The subline is important for studying MERTK -/- -induced retinitis pigmentosa. MERTK mutations are associate with rod-cone dystrophies. To enable investigations into the mechanism of this disease, we generated a cell line resource of H9 human embryonic stem cells harboring large fragment deletion mutation in a homozygous state in exon 19 of the MERTK gene. This subline expressed pluripotent stem cell markers, presented a normal karyotype, and preserved the ability to differentiate into endodermal, mesodermal, and ectodermal lineages." @default.
- W3136149334 created "2021-03-29" @default.
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- W3136149334 date "2021-05-01" @default.
- W3136149334 modified "2023-10-18" @default.
- W3136149334 title "Generation of a homozygous CRISPR/Cas9-mediated knockout H9 hESC subline for the MERTK locus" @default.
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- W3136149334 doi "https://doi.org/10.1016/j.scr.2021.102310" @default.
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