FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136149877> ?p ?o ?g. }

• W3136149877 abstract "FtsJ RNA 2'-O-methyltransferase 1 (FTSJ1) gene has been implicated in X-linked intellectual disability (XLID), but the molecular pathogenesis is unknown. We show that Ftsj1 is responsible for 2'-O-methylation of 11 species of cytosolic transfer RNAs (tRNAs) at the anticodon region, and these modifications are abolished in Ftsj1 knockout (KO) mice and XLID patient-derived cells. Loss of 2'-O-methylation in Ftsj1 KO mouse selectively reduced the steady-state level of tRNAPhe in the brain, resulting in a slow decoding at Phe codons. Ribosome profiling showed that translation efficiency is significantly reduced in a subset of genes that need to be efficiently translated to support synaptic organization and functions. Ftsj1 KO mice display immature synaptic morphology and aberrant synaptic plasticity, which are associated with anxiety-like and memory deficits. The data illuminate a fundamental role of tRNA modification in the brain through regulation of translation efficiency and provide mechanistic insights into FTSJ1-related XLID." @default.
• W3136149877 created "2021-03-29" @default.
• W3136149877 creator A5001653266 @default.
• W3136149877 creator A5002837769 @default.
• W3136149877 creator A5003699110 @default.
• W3136149877 creator A5007362659 @default.
• W3136149877 creator A5018821173 @default.
• W3136149877 creator A5019246756 @default.
• W3136149877 creator A5027765779 @default.
• W3136149877 creator A5027920594 @default.
• W3136149877 creator A5032868995 @default.
• W3136149877 creator A5047708722 @default.
• W3136149877 creator A5051282867 @default.
• W3136149877 creator A5052079715 @default.
• W3136149877 creator A5052497585 @default.
• W3136149877 creator A5054890308 @default.
• W3136149877 creator A5058793966 @default.
• W3136149877 creator A5065079935 @default.
• W3136149877 creator A5068694814 @default.
• W3136149877 creator A5081069296 @default.
• W3136149877 creator A5091595687 @default.
• W3136149877 date "2021-03-26" @default.
• W3136149877 modified "2023-10-01" @default.
• W3136149877 title "Loss of Ftsj1 perturbs codon-specific translation efficiency in the brain and is associated with X-linked intellectual disability" @default.
• W3136149877 cites W1869589248 @default.
• W3136149877 cites W1885358257 @default.
• W3136149877 cites W1935366897 @default.
• W3136149877 cites W1964160578 @default.
• W3136149877 cites W1975106872 @default.
• W3136149877 cites W1987609176 @default.
• W3136149877 cites W1989982790 @default.
• W3136149877 cites W1990393276 @default.
• W3136149877 cites W1991426898 @default.
• W3136149877 cites W1993255478 @default.
• W3136149877 cites W2004892117 @default.
• W3136149877 cites W2015964634 @default.
• W3136149877 cites W2031388575 @default.
• W3136149877 cites W2036448005 @default.
• W3136149877 cites W2037006420 @default.
• W3136149877 cites W2049669528 @default.
• W3136149877 cites W2052827796 @default.
• W3136149877 cites W2059346861 @default.
• W3136149877 cites W2061186744 @default.
• W3136149877 cites W2076772609 @default.
• W3136149877 cites W2077997107 @default.
• W3136149877 cites W2085636962 @default.
• W3136149877 cites W2086157203 @default.
• W3136149877 cites W2087203385 @default.
• W3136149877 cites W2099590260 @default.
• W3136149877 cites W2114147818 @default.
• W3136149877 cites W2115495500 @default.
• W3136149877 cites W2116976668 @default.
• W3136149877 cites W2122665705 @default.
• W3136149877 cites W2124736941 @default.
• W3136149877 cites W2124924991 @default.
• W3136149877 cites W2130410032 @default.
• W3136149877 cites W2142189265 @default.
• W3136149877 cites W2143801120 @default.
• W3136149877 cites W2154799379 @default.
• W3136149877 cites W2223836536 @default.
• W3136149877 cites W2260464130 @default.
• W3136149877 cites W2266589141 @default.
• W3136149877 cites W2344860861 @default.
• W3136149877 cites W2547372962 @default.
• W3136149877 cites W2606518593 @default.
• W3136149877 cites W2708317524 @default.
• W3136149877 cites W2751862616 @default.
• W3136149877 cites W2791171014 @default.
• W3136149877 cites W2794635962 @default.
• W3136149877 cites W2797564997 @default.
• W3136149877 cites W2800397674 @default.
• W3136149877 cites W2802631831 @default.
• W3136149877 cites W2888674680 @default.
• W3136149877 cites W2902566879 @default.
• W3136149877 cites W2905583756 @default.
• W3136149877 cites W2912327568 @default.
• W3136149877 cites W2915489297 @default.
• W3136149877 cites W2917207851 @default.
• W3136149877 cites W2955407968 @default.
• W3136149877 cites W2971904993 @default.
• W3136149877 cites W2993094148 @default.
• W3136149877 cites W2999772998 @default.
• W3136149877 cites W3036386150 @default.
• W3136149877 cites W3082382384 @default.
• W3136149877 doi "https://doi.org/10.1126/sciadv.abf3072" @default.
• W3136149877 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7997516" @default.
• W3136149877 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33771871" @default.
• W3136149877 hasPublicationYear "2021" @default.
• W3136149877 type Work @default.
• W3136149877 sameAs 3136149877 @default.
• W3136149877 citedByCount "27" @default.
• W3136149877 countsByYear W31361498772021 @default.
• W3136149877 countsByYear W31361498772022 @default.
• W3136149877 countsByYear W31361498772023 @default.
• W3136149877 crossrefType "journal-article" @default.
• W3136149877 hasAuthorship W3136149877A5001653266 @default.
• W3136149877 hasAuthorship W3136149877A5002837769 @default.
• W3136149877 hasAuthorship W3136149877A5003699110 @default.
• W3136149877 hasAuthorship W3136149877A5007362659 @default.
• W3136149877 hasAuthorship W3136149877A5018821173 @default.

• next