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• W3136153980 abstract "Abstract In humans and other eukaryotes, histone post-translational modifications (hPTMs) play an essential role in the epigenetic control of gene expression. In trypanosomatid parasites, conversely, gene regulation occurs mainly at the post-transcriptional level. However, our group has recently shown that hPTMs are abundant and varied in Trypanosoma cruzi , the etiological agent of Chagas Disease, signaling for possible conserved epigenetic functions. Here, we applied an optimized mass spectrometry-based proteomic workflow to provide a high-confidence comprehensive map of hPTMs, distributed in all canonical, variant and linker histones of T. cruzi . Our work expands the number of known T. cruzi hPTMs by almost 2-fold, representing the largest dataset of hPTMs available to any trypanosomatid to date, and can be used as a basis for functional studies on the dynamic regulation of chromatin by epigenetic mechanisms and the selection of candidates for the development of epigenetic drugs against trypanosomatids." @default.
• W3136153980 created "2021-03-29" @default.
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• W3136153980 date "2021-03-25" @default.
• W3136153980 modified "2023-10-03" @default.
• W3136153980 title "An updated map of Trypanosoma cruzi histone post-translational modifications" @default.
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• W3136153980 doi "https://doi.org/10.1038/s41597-021-00818-w" @default.
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