FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136156548> ?p ?o ?g. }

• W3136156548 endingPage "370" @default.
• W3136156548 startingPage "363" @default.
• W3136156548 abstract "Objective: Methylated CpG binding protein 2 (MeCP2) is closely associated with heart failure, but its role in I/R injury remains unclear. The purpose of this study was to explore the role and underling mechanism of MeCP2 in myocardial I/R injury.Methods: Hypoxia/reperfusion (H/R)-induced H9c2 cardiomyocytes was used to establish an in vitro I/R injury model. Oxidative stress was assessed by measuring reactive oxygen species (ROS) generation, malondialdehyde (MDA) content and superoxide dismutase (SOD) activity. Cell viability and cell cycle arrest were evaluated by the Cell Counting Kit-8 assay and cell cycle assay, respectively. Apoptosis was determined using flow cytometry analysis.Results: The expression of MeCP2 in H9c2 cells was decreased after H/R treatment. The overexpression of MeCP2 inhibited H/R-induced oxidative stress, cell cycle arrest and apoptosis of H9c2 cells. Moreover, MeCP2 inhibited the activation of secreted frizzled related protein 4 (SFRP4)/Wnt/β-catenin axis, and SFRP4 relieved the effect of MeCP2 on oxidative stress, cell cycle arrest and apoptosis in H/R-induced H9c2 cells.Conclusions: MeCP2 attenuated H/R-induced injury in H9c2 cardiomyocytes by modulating the SFRP4/Wnt/β-catenin axis, which suggested that MeCP2 might serve as a therapeutic target of patients with AMI after reperfusion." @default.
• W3136156548 created "2021-03-29" @default.
• W3136156548 creator A5002516682 @default.
• W3136156548 creator A5015105154 @default.
• W3136156548 creator A5035701638 @default.
• W3136156548 creator A5073930897 @default.
• W3136156548 date "2021-04-15" @default.
• W3136156548 modified "2023-10-17" @default.
• W3136156548 title "MeCP2 attenuates cardiomyocyte hypoxia/reperfusion-induced injury via regulation of the SFRP4/Wnt/β-catenin axis" @default.
• W3136156548 cites W1435175130 @default.
• W3136156548 cites W1785579409 @default.
• W3136156548 cites W1972462604 @default.
• W3136156548 cites W2073055626 @default.
• W3136156548 cites W2139522433 @default.
• W3136156548 cites W2272713913 @default.
• W3136156548 cites W2295239707 @default.
• W3136156548 cites W2318231361 @default.
• W3136156548 cites W2608737901 @default.
• W3136156548 cites W2613119278 @default.
• W3136156548 cites W2613970646 @default.
• W3136156548 cites W2739534676 @default.
• W3136156548 cites W2742682568 @default.
• W3136156548 cites W2755967972 @default.
• W3136156548 cites W2784299734 @default.
• W3136156548 cites W2814880030 @default.
• W3136156548 cites W2901716735 @default.
• W3136156548 cites W2920198565 @default.
• W3136156548 cites W2942829517 @default.
• W3136156548 cites W2943478561 @default.
• W3136156548 cites W2944589113 @default.
• W3136156548 cites W2973973573 @default.
• W3136156548 cites W2998513787 @default.
• W3136156548 cites W2999589863 @default.
• W3136156548 cites W3009550588 @default.
• W3136156548 cites W3010237386 @default.
• W3136156548 cites W3012557394 @default.
• W3136156548 cites W3013473263 @default.
• W3136156548 cites W3014638840 @default.
• W3136156548 cites W3015238622 @default.
• W3136156548 cites W3023554164 @default.
• W3136156548 cites W3024662414 @default.
• W3136156548 cites W3026335214 @default.
• W3136156548 cites W3035888356 @default.
• W3136156548 cites W3038635558 @default.
• W3136156548 cites W304038711 @default.
• W3136156548 cites W3042912738 @default.
• W3136156548 cites W3043686868 @default.
• W3136156548 cites W3081384227 @default.
• W3136156548 cites W3081762846 @default.
• W3136156548 doi "https://doi.org/10.1080/1354750x.2021.1903999" @default.
• W3136156548 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33726573" @default.
• W3136156548 hasPublicationYear "2021" @default.
• W3136156548 type Work @default.
• W3136156548 sameAs 3136156548 @default.
• W3136156548 citedByCount "8" @default.
• W3136156548 countsByYear W31361565482021 @default.
• W3136156548 countsByYear W31361565482022 @default.
• W3136156548 countsByYear W31361565482023 @default.
• W3136156548 crossrefType "journal-article" @default.
• W3136156548 hasAuthorship W3136156548A5002516682 @default.
• W3136156548 hasAuthorship W3136156548A5015105154 @default.
• W3136156548 hasAuthorship W3136156548A5035701638 @default.
• W3136156548 hasAuthorship W3136156548A5073930897 @default.
• W3136156548 hasConcept C105696609 @default.
• W3136156548 hasConcept C126322002 @default.
• W3136156548 hasConcept C137620995 @default.
• W3136156548 hasConcept C153911025 @default.
• W3136156548 hasConcept C185592680 @default.
• W3136156548 hasConcept C190283241 @default.
• W3136156548 hasConcept C2775838275 @default.
• W3136156548 hasConcept C2776151105 @default.
• W3136156548 hasConcept C2778401633 @default.
• W3136156548 hasConcept C2780114680 @default.
• W3136156548 hasConcept C29537977 @default.
• W3136156548 hasConcept C30145163 @default.
• W3136156548 hasConcept C48349386 @default.
• W3136156548 hasConcept C53227056 @default.
• W3136156548 hasConcept C541997718 @default.
• W3136156548 hasConcept C553184892 @default.
• W3136156548 hasConcept C55493867 @default.
• W3136156548 hasConcept C62112901 @default.
• W3136156548 hasConcept C62478195 @default.
• W3136156548 hasConcept C71924100 @default.
• W3136156548 hasConcept C86803240 @default.
• W3136156548 hasConcept C95444343 @default.
• W3136156548 hasConceptScore W3136156548C105696609 @default.
• W3136156548 hasConceptScore W3136156548C126322002 @default.
• W3136156548 hasConceptScore W3136156548C137620995 @default.
• W3136156548 hasConceptScore W3136156548C153911025 @default.
• W3136156548 hasConceptScore W3136156548C185592680 @default.
• W3136156548 hasConceptScore W3136156548C190283241 @default.
• W3136156548 hasConceptScore W3136156548C2775838275 @default.
• W3136156548 hasConceptScore W3136156548C2776151105 @default.
• W3136156548 hasConceptScore W3136156548C2778401633 @default.
• W3136156548 hasConceptScore W3136156548C2780114680 @default.
• W3136156548 hasConceptScore W3136156548C29537977 @default.
• W3136156548 hasConceptScore W3136156548C30145163 @default.
• W3136156548 hasConceptScore W3136156548C48349386 @default.

• next