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• W3136160764 abstract "Our previous investigations showed that tissue stem cells in the maculae flavae (a stem cell niche) form colonies in vivo like stem cells in vitro. However, the roles of colony-forming cells in the maculae flavae in vivo have not yet been determined.This study investigated the metabolism of the colony-forming tissue stem cells in the maculae flavae of the human adult vocal fold.Histologic analysis of the human vocal folds.Three normal human adult vocal folds were investigated under transmission electron microscopy and light microscopy including immunohistochemistry.Mitochondrial cristae of the colony-forming cells in the maculae flavae were sparse. Hence, the microstructural features of the mitochondria suggested that their metabolic activity and oxidative phosphorylation were low. Colony-forming cells strongly expressed glucose transporter-1 and glycolytic enzymes (hexokinase II, glyceraldehyde-3-phosphate dehydrogenase and lactate dehydrogenase A). The colony-forming cells did not express phosphofructokinase-1 but did express glucose-6-phosphate dehydrogenase indicating the cells relied more on the pentose phosphate pathway. Since the colony-forming cells expressed lactate dehydrogenase A, cells seemed to rely more on anaerobic glycolysis in an anaerobic microenvironment.The present study is consistent with the hypothesis that the colony-forming tissue stem cells in the maculae flavae of the human adult vocal fold seemed to rely more on anaerobic glycolysis using the pentose phosphate pathway for energy supply in vivo. Microstructural features of the mitochondria and expressed glycolytic enzymes of the colony-forming cells in the maculae flavae suggested that the oxidative phosphorylation activity was low.In an anaerobic microenvironment in vivo, there is likely a complex cross-talk regarding the metabolism between the colony-forming aggregated cells along the adhesion machinery and chemical signaling pathways, which reduces toxic oxygen species and is favorable to maintaining the stemness and undifferentiated states of the tissue stem cells.NA." @default.
• W3136160764 created "2021-03-29" @default.
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• W3136160764 date "2021-03-22" @default.
• W3136160764 modified "2023-10-14" @default.
• W3136160764 title "Role of colony‐forming tissue stem cells in the macula flava of the human vocal fold in vivo" @default.
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• W3136160764 doi "https://doi.org/10.1002/lio2.550" @default.
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