FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136162324> ?p ?o ?g. }

• W3136162324 abstract "Abstract Background and aims Previous study disclosed Fucosyltransferase 2 ( Fut2 ) gene as a IBD risk locus. This study aimed to explore the mechanism of Fut2 in IBD susceptibility and to propose a new strategy for the treatment of IBD. Methods Intestinal epithelium-specific Fut2 knockout ( Fut2 △IEC ) mice was used. Colitis was induced by dextran sulfate sodium (DSS). The composition and diversity of gut microbiota were assessed via 16S rRNA analysis and the metabolomic findings was obtained from mice feces via metabolite profiling. The fecal microbiota transplantation (FMT) experiment was performed to confirm the association of gut microbiota and LPC. WT mice were treated with Lysophosphatidylcholine (LPC) to verify its impact on colitis. Results The expression of Fut 2 and α-1,2-fucosylation in colonic tissues were decreased in patients with UC (UC vs. control, P = 0.036) and CD (CD vs. control, P = 0.031). When treated with DSS, in comparison to WT mice, more severe intestinal inflammation and destructive barrier functions in Fut2 △IEC mice was noted. Lower gut microbiota diversity was observed in Fut2 △IEC mice compared with WT mice ( p < 0.001). When exposed to DSS, gut bacterial diversity and composition altered obviously in Fut2 △IEC mice and the fecal concentration of LPC was increased. FMT experiment revealed that mice received the fecal microbiota from Fut2 △IEC mice exhibited more severe colitis and higher fecal LPC concentration. Correlation analysis showed that the concentration of LPC was positively correlated with four bacteria— Escherichia , Bilophila , Enterorhabdus and Gordonibacter . Furthermore, LPC was proved to promote the release of pro-inflammatory cytokines and damage epithelial barrier in vitro and in vivo . Conclusion Fut 2 and α-1,2-fucosylation in colon were decreased not only in CD but also in UC patients. Gut microbiota in Fut2 △IEC mice is altered structurally and functionally, promoting generation of LPC which was proved to promote inflammation and damage epithelial barrier." @default.
• W3136162324 created "2021-03-29" @default.
• W3136162324 creator A5007982287 @default.
• W3136162324 creator A5023037844 @default.
• W3136162324 creator A5033184102 @default.
• W3136162324 creator A5035153981 @default.
• W3136162324 creator A5038427310 @default.
• W3136162324 creator A5060622857 @default.
• W3136162324 creator A5064871335 @default.
• W3136162324 creator A5079030768 @default.
• W3136162324 creator A5079117775 @default.
• W3136162324 creator A5088391708 @default.
• W3136162324 date "2021-03-15" @default.
• W3136162324 modified "2023-10-17" @default.
• W3136162324 title "Gut microbiota-mediated lysophosphatidylcholine generation promotes colitis in intestinal epithelium-specific Fut2 deficiency" @default.
• W3136162324 cites W1581010761 @default.
• W3136162324 cites W1993513230 @default.
• W3136162324 cites W2040127574 @default.
• W3136162324 cites W2075988234 @default.
• W3136162324 cites W2076519131 @default.
• W3136162324 cites W2089611985 @default.
• W3136162324 cites W2097875133 @default.
• W3136162324 cites W2104956723 @default.
• W3136162324 cites W2106779017 @default.
• W3136162324 cites W2110300022 @default.
• W3136162324 cites W2117088514 @default.
• W3136162324 cites W2119783212 @default.
• W3136162324 cites W2129690444 @default.
• W3136162324 cites W2142671825 @default.
• W3136162324 cites W2154555351 @default.
• W3136162324 cites W2167700091 @default.
• W3136162324 cites W2182578492 @default.
• W3136162324 cites W2235103312 @default.
• W3136162324 cites W2346752870 @default.
• W3136162324 cites W2545115658 @default.
• W3136162324 cites W2552283579 @default.
• W3136162324 cites W2555394510 @default.
• W3136162324 cites W2571437448 @default.
• W3136162324 cites W2736839127 @default.
• W3136162324 cites W2751577865 @default.
• W3136162324 cites W2765192428 @default.
• W3136162324 cites W2767838428 @default.
• W3136162324 cites W2769786924 @default.
• W3136162324 cites W2781836545 @default.
• W3136162324 cites W2808457437 @default.
• W3136162324 cites W2810056299 @default.
• W3136162324 cites W2963871394 @default.
• W3136162324 cites W2964277243 @default.
• W3136162324 cites W2991550463 @default.
• W3136162324 cites W2994816480 @default.
• W3136162324 cites W3001290322 @default.
• W3136162324 cites W4294216483 @default.
• W3136162324 doi "https://doi.org/10.1186/s12929-021-00711-z" @default.
• W3136162324 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7958775" @default.
• W3136162324 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33722220" @default.
• W3136162324 hasPublicationYear "2021" @default.
• W3136162324 type Work @default.
• W3136162324 sameAs 3136162324 @default.
• W3136162324 citedByCount "40" @default.
• W3136162324 countsByYear W31361623242021 @default.
• W3136162324 countsByYear W31361623242022 @default.
• W3136162324 countsByYear W31361623242023 @default.
• W3136162324 crossrefType "journal-article" @default.
• W3136162324 hasAuthorship W3136162324A5007982287 @default.
• W3136162324 hasAuthorship W3136162324A5023037844 @default.
• W3136162324 hasAuthorship W3136162324A5033184102 @default.
• W3136162324 hasAuthorship W3136162324A5035153981 @default.
• W3136162324 hasAuthorship W3136162324A5038427310 @default.
• W3136162324 hasAuthorship W3136162324A5060622857 @default.
• W3136162324 hasAuthorship W3136162324A5064871335 @default.
• W3136162324 hasAuthorship W3136162324A5079030768 @default.
• W3136162324 hasAuthorship W3136162324A5079117775 @default.
• W3136162324 hasAuthorship W3136162324A5088391708 @default.
• W3136162324 hasBestOaLocation W31361623241 @default.
• W3136162324 hasConcept C126322002 @default.
• W3136162324 hasConcept C203014093 @default.
• W3136162324 hasConcept C2775862500 @default.
• W3136162324 hasConcept C2776330855 @default.
• W3136162324 hasConcept C2778260677 @default.
• W3136162324 hasConcept C2778596009 @default.
• W3136162324 hasConcept C2778918659 @default.
• W3136162324 hasConcept C2779134260 @default.
• W3136162324 hasConcept C2779280984 @default.
• W3136162324 hasConcept C2780206646 @default.
• W3136162324 hasConcept C2780305828 @default.
• W3136162324 hasConcept C2780941987 @default.
• W3136162324 hasConcept C41625074 @default.
• W3136162324 hasConcept C523546767 @default.
• W3136162324 hasConcept C539455810 @default.
• W3136162324 hasConcept C54355233 @default.
• W3136162324 hasConcept C61716771 @default.
• W3136162324 hasConcept C71924100 @default.
• W3136162324 hasConcept C86803240 @default.
• W3136162324 hasConcept C89423630 @default.
• W3136162324 hasConceptScore W3136162324C126322002 @default.
• W3136162324 hasConceptScore W3136162324C203014093 @default.
• W3136162324 hasConceptScore W3136162324C2775862500 @default.
• W3136162324 hasConceptScore W3136162324C2776330855 @default.
• W3136162324 hasConceptScore W3136162324C2778260677 @default.
• W3136162324 hasConceptScore W3136162324C2778596009 @default.

• next