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• W3136163171 endingPage "104430" @default.
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• W3136163171 abstract "During the cardiac cycle, electrical excitation is coupled with mechanical response of the myocardium. Besides the active contraction, passive mechanics plays an important role, and its behaviour differs in healthy and diseased hearts as well as among different animal species. The aim of this study is the characterisation of passive mechanical properties in healthy and infarcted rat myocardium by means of mechanical testing and subsequent parameter fitting. Elasticity assessments via uniaxial extension tests are performed on healthy and infarcted tissue samples from left ventricular rat myocardium. In order to fully characterise the orthotropic cardiac tissue, our experimental data are combined with other previously published tests in rats – shear tests on healthy myocardium and equibiaxial tests on infarcted tissue. In a first step, we calibrate the Holzapfel-Ogden strain energy function in the healthy case. Sa far, this orthotropic constitutive law for the passive myocardium has been fitted to experimental data in several species, however there is a lack of an appropriate parameter set for the rat. With our determined parameters, a finite element simulation of the end-diastolic filling is performed. In a second step, we propose a model for the infarcted tissue. It is represented as a mixture of intact myocardium and a transversely isotropic scar structure. In our mechanical experiments, the tissue after myocardial infarction shows significantly stiffer behaviour than in the healthy case, and the stiffness correlates with the amount of fibrosis. A similar relationship is observed in the computational simulation of the end-diastolic filling. We conclude that our new proposed material model can capture the behaviour of two kinds of tissues – healthy and infarcted rat myocardium, and its calibration with the fitted parameters represents the experimental data well." @default.
• W3136163171 created "2021-03-29" @default.
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• W3136163171 date "2021-07-01" @default.
• W3136163171 modified "2023-09-27" @default.
• W3136163171 title "Passive mechanical properties in healthy and infarcted rat left ventricle characterised via a mixture model" @default.
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• W3136163171 doi "https://doi.org/10.1016/j.jmbbm.2021.104430" @default.
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• W3136163171 hasPublicationYear "2021" @default.
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