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- W3136163204 abstract "BACKGROUND The proteinuria selectivity index (PSI) can predict the response to prednisone in the primary nephrotic syndrome (PNS). OBJECTIVE To determine the association of prednisone response with the PSI in patients with PNS. MATERIAL AND METHODS With analytical cross-sectional design, pediatric patients with PNS were studied with at least six months of prior follow-up, at the Nuevo Hospital Civil de Guadalajara from 2014 to 2015. They were divided into poor response to prednisone (frequent relapses or resistance) and good response (habitual relapses). PSI was calculated with serum and urinary measurement of IgG and transferrin. Chi square and OR were used, with 95% CI. RESULTS 67 patients with relapsing PNS were studied. The response to prednisone had been good in 33 (49.3%) and poor in 34 (50.7%). The PSI was ≤ 0.10 mg/mg in 23/67 (34.3%); 0.11-0.19 mg/mg in 15/67 (22.4%); and ≥ 0.20 mg/mg 29/67 (43.3%). 3/34 patients (8.8%) presented ≤ 0.1 mg/mg with poor response to prednisone and 20/33 presented good response (60.6%) (p < 0.001; OR: 0.6; 95% CI, 0.010-20). PSI between 0.11-0-19 mg/mg occurred in 8/34 patients (23%) with poor response to prednisone and in 7/33 with good response (21%). PSI ≥ 0.20 mg/mg resulted in 23/34 patients (67.6%) with poor response to the steroid and in 6/33 with good response (18.2%) (p < 0.001; OR: 9.4; 95% CI, 3.01-29.42). CONCLUSIONS In children with PNS, a PSI ≥ 0.20 mg/mg was associated with a poor response to prednisone treatment and a PSI ≤ 0.10 mg/mg with a satisfactory response." @default.
- W3136163204 created "2021-03-29" @default.
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- W3136163204 date "2021-08-05" @default.
- W3136163204 modified "2023-09-27" @default.
- W3136163204 title "Selectividad de proteinuria y respuesta a prednisona en niños con síndrome nefrótico" @default.
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- W3136163204 doi "https://doi.org/10.24875/rmimss.m21000034" @default.
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