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• W3136166813 abstract "Glia in the central nervous system engulf neuron fragments to remodel synapses and recycle photoreceptor outer segments. Whether glia passively clear shed neuronal debris or actively prune neuron fragments is unknown. How pruning of single-neuron endings impacts animal behavior is also unclear. Here, we report our discovery of glia-directed neuron pruning in Caenorhabditis elegans. Adult C. elegans AMsh glia engulf sensory endings of the AFD thermosensory neuron by repurposing components of the conserved apoptotic corpse phagocytosis machinery. The phosphatidylserine (PS) flippase TAT-1/ATP8A functions with glial PS-receptor PSR-1/PSR and PAT-2/α-integrin to initiate engulfment. This activates glial CED-10/Rac1 GTPase through the ternary GEF complex of CED-2/CrkII, CED-5/DOCK180, CED-12/ELMO. Execution of phagocytosis uses the actin-remodeler WSP-1/nWASp. This process dynamically tracks AFD activity and is regulated by temperature, the AFD sensory input. Importantly, glial CED-10 levels regulate engulfment rates downstream of neuron activity, and engulfment-defective mutants exhibit altered AFD-ending shape and thermosensory behavior. Our findings reveal a molecular pathway underlying glia-dependent engulfment in a peripheral sense-organ and demonstrate that glia actively engulf neuron fragments, with profound consequences on neuron shape and animal sensory behavior." @default.
• W3136166813 created "2021-03-29" @default.
• W3136166813 creator A5009110539 @default.
• W3136166813 creator A5016406734 @default.
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• W3136166813 creator A5043121672 @default.
• W3136166813 creator A5069170881 @default.
• W3136166813 creator A5072674777 @default.
• W3136166813 creator A5074405232 @default.
• W3136166813 date "2021-03-24" @default.
• W3136166813 modified "2023-10-17" @default.
• W3136166813 title "Glia actively sculpt sensory neurons by controlled phagocytosis to tune animal behavior" @default.
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