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- W3136168340 abstract "BJECTIVES The objective of this study was to assess the influence or effect of vaginal pH on the effectiveness of misoprostol as a means of cervical ripening. Specific objectives were: 1. To determine whether vaginal pH will affect the dose of misoprostol that will achieve cervical ripening. 2. To assess the effect of vaginal pH on the interval between application to cervical ripening. 3. To assess the effect of vaginal pH on the interval between application to onset of uterine contractions. 4. To assess the effect of vaginal pH on the interval between application and delivery of the baby Other outcome measures such as the dose of misoprostol and feto-maternal adverse effects in relation to vaginal pH were assessed. Commented [DF1]: I am not certain this was the way this was written in your proposal! 2 Methodology It was a cross-sectional descriptive study of women scheduled for induction of labour at UCH between December 2010 and January 2011. A total population survey of the women planned for induction was done. Eighty women who consented to the study had their vaginal pH determined before insertion of first dose of misoprostol and based on the result they were categorised into first group of women with vaginal pH< 5 and the second group of women with vaginal pH≥5. The women had their labour supervised by the obstetric team in the Labour ward. A data collecting sheet was used by the investigator to collect data relating to demographic characteristics, labour effects, outcomes of the induction. Data collected was entered into Microsoft Excel (2007) spread sheet and analysed using the SPSS version 17. Quantitative variables were summarized as means and standard deviation while qualitative variables were represented as proportions. The Chi square test and Fisher’s exact test were used to test for associations between categorical variables. Continuous variables were compared using independent t test. Linear regression analysis was conducted to derive significant predictors of misoprostol effect and adjust for the influence of confounding variables. 3 Results The demographic characteristics of the women in the two groups were comparable. Their mean age was 30.46 ± 4.21 years. Most of the women (61%) had vaginal pH < 5. There was no significant difference in the mean dose of misoprostol required in the two groups of women (p = 0.413). There was also no significant difference in the oxytocin dose in the two groups of women. Mean duration between insertion of first dose of misoprostol and delivery in women with pH < 5 was 928 ± 422 minutes while it was 943± 494 minutes in women with pH ≥ 5. (p = 0.839). Mean duration to onset of contraction in the first group of women was 446±259 minutes while it was 496±360 minutes in the second group of women (p=0.532). Mean duration to cervical ripening in the first group was 360 ± 220 minutes while it was 540 ± 301minutes in the other group. (p = 0.178) Women with lower vaginal pH group had more of vaginal delivery compared to those in the higher group. The high vaginal group had higher proportion of women having caesarean delivery (p = 0.002). There were no significant differences in adverse outcomes in the mothers and the neonates in the two groups of women. Parity was a significant predictor for interval to onset of contraction, cervical ripening and delivery. 4 Conclusion There appears to be no significant difference in the interval to onset of contractions, cervical ripening and delivery in the two pH groups however the women with high vaginal pH tend to have higher rates of caesarean section compared to women with lower vaginal pH." @default.
- W3136168340 created "2021-03-29" @default.
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- W3136168340 date "2011-01-01" @default.
- W3136168340 modified "2023-09-23" @default.
- W3136168340 title "EFFECT OF VAGINAL PH ON EFFECTIVENESS OF MISOPROSTOL FOR CERVICAL RIPENING" @default.
- W3136168340 hasPublicationYear "2011" @default.
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