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- W3136172877 abstract "Circular RNAs (circRNAs) are a class of novel non-coding RNAs (ncRNAs). Emerging evidence demonstrates that circRNAs play crucial roles in many biological processes by regulating linear RNA transcription, downstream gene expression and protein or peptide translation. Meanwhile, recent studies have suggested that circRNAs have the potential to be oncogenic or anti-oncogenic and play vital regulatory roles in the initiation and progression of tumors. Circular RNA Forkhead box O3 (circ-Foxo3, hsa_circ_0006404) is encoded by the human FOXO3 gene and is one of the most studied circular RNAs acting as a sponge for potential microRNAs (miRNAs) ( Du et al., 2016 ). Previous studies have reported that circ-Foxo3 is involved in the development and tumorigenesis of a variety of cancers (bladder, gastric, acute lymphocytic leukemia, glioma, etc.). In this review, we summarize the current studies concerning circ-Foxo3 deregulation and the correlative mechanism in various human cancers. We also point out the potential clinical applications of this circRNA as a biomarker for cancer diagnosis and prognosis." @default.
- W3136172877 created "2021-03-29" @default.
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- W3136172877 creator A5091752652 @default.
- W3136172877 date "2021-03-23" @default.
- W3136172877 modified "2023-10-17" @default.
- W3136172877 title "Circular RNA Foxo3: A Promising Cancer-Associated Biomarker" @default.
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- W3136172877 doi "https://doi.org/10.3389/fgene.2021.652995" @default.
- W3136172877 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8021895" @default.
- W3136172877 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33833780" @default.
- W3136172877 hasPublicationYear "2021" @default.