FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136174586> ?p ?o ?g. }

• W3136174586 abstract "Hepatocellular carcinoma (HCC) is the leading cause of death in patients with cirrhosis, primarily due to failed early detection. HCC screening is recommended among individuals with cirrhosis using biannual abdominal ultrasound, for earlier tumor detection, administration of curative treatment, and improved survival. Surveillance by imaging with or without biomarkers such as alpha-fetoprotein (AFP) remains suboptimal for early stage HCC detection. Here we report on the development and assessment of methylation biomarkers from liquid biopsies for HCC surveillance in cirrhotic patients.DNA methylation markers including the HCCBloodTest (Epigenomics AG) and a DNA-methylation panel established by next generation sequencing (NGS) were assessed using a training/testing design. The NGS panel algorithm was established in a training study (41 HCC patients; 46 cirrhotic non-HCC controls). For testing, plasma samples were obtained from cirrhotic patients (Child class A or B) with (60) or without (103) early stage HCC (BCLC stage 0, A, B). The assays were then tested using blinded sample sets and analyzed by preset algorithms.The HCCBloodTest and the NGS panel exhibited 76.7% and 57% sensitivities at 64.1% and 97% specificity, respectively. In a post-hoc analysis, a combination of the NGS panel with AFP (20 ng/mL) achieved 68% sensitivity at 97% specificity (AUC = 0.9).Methylation biomarkers in cell free plasma DNA provide a new alternative for HCC surveillance. Multiomic panels comprising DNA methylation markers with other biological markers, such as AFP, provide an option to further increase the overall clinical performance of surveillance via minimally invasive blood samples.Test set study-ClinicalTrials.gov (NCT03804593) January 11, 2019, retrospectively registered." @default.
• W3136174586 created "2021-03-29" @default.
• W3136174586 creator A5001055062 @default.
• W3136174586 creator A5002828150 @default.
• W3136174586 creator A5003462114 @default.
• W3136174586 creator A5019681276 @default.
• W3136174586 creator A5019990218 @default.
• W3136174586 creator A5021248078 @default.
• W3136174586 creator A5026285157 @default.
• W3136174586 creator A5029549591 @default.
• W3136174586 creator A5034454114 @default.
• W3136174586 creator A5036822225 @default.
• W3136174586 creator A5041456196 @default.
• W3136174586 creator A5050702878 @default.
• W3136174586 creator A5070061845 @default.
• W3136174586 creator A5090803693 @default.
• W3136174586 date "2021-03-25" @default.
• W3136174586 modified "2023-10-18" @default.
• W3136174586 title "Plasma cell free DNA methylation markers for hepatocellular carcinoma surveillance in patients with cirrhosis: a case control study" @default.
• W3136174586 cites W2059172245 @default.
• W3136174586 cites W2083555181 @default.
• W3136174586 cites W2089050775 @default.
• W3136174586 cites W2103081012 @default.
• W3136174586 cites W2123174009 @default.
• W3136174586 cites W2123730033 @default.
• W3136174586 cites W2157107905 @default.
• W3136174586 cites W2171017754 @default.
• W3136174586 cites W2467136872 @default.
• W3136174586 cites W2751273694 @default.
• W3136174586 cites W2786099441 @default.
• W3136174586 cites W2794450296 @default.
• W3136174586 cites W2796067155 @default.
• W3136174586 cites W2901770926 @default.
• W3136174586 cites W2952214509 @default.
• W3136174586 cites W2964930572 @default.
• W3136174586 cites W2970079004 @default.
• W3136174586 cites W2977680082 @default.
• W3136174586 cites W2997319650 @default.
• W3136174586 cites W3014665169 @default.
• W3136174586 cites W3091665757 @default.
• W3136174586 doi "https://doi.org/10.1186/s12876-021-01714-8" @default.
• W3136174586 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7995734" @default.
• W3136174586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33765926" @default.
• W3136174586 hasPublicationYear "2021" @default.
• W3136174586 type Work @default.
• W3136174586 sameAs 3136174586 @default.
• W3136174586 citedByCount "11" @default.
• W3136174586 countsByYear W31361745862021 @default.
• W3136174586 countsByYear W31361745862022 @default.
• W3136174586 countsByYear W31361745862023 @default.
• W3136174586 crossrefType "journal-article" @default.
• W3136174586 hasAuthorship W3136174586A5001055062 @default.
• W3136174586 hasAuthorship W3136174586A5002828150 @default.
• W3136174586 hasAuthorship W3136174586A5003462114 @default.
• W3136174586 hasAuthorship W3136174586A5019681276 @default.
• W3136174586 hasAuthorship W3136174586A5019990218 @default.
• W3136174586 hasAuthorship W3136174586A5021248078 @default.
• W3136174586 hasAuthorship W3136174586A5026285157 @default.
• W3136174586 hasAuthorship W3136174586A5029549591 @default.
• W3136174586 hasAuthorship W3136174586A5034454114 @default.
• W3136174586 hasAuthorship W3136174586A5036822225 @default.
• W3136174586 hasAuthorship W3136174586A5041456196 @default.
• W3136174586 hasAuthorship W3136174586A5050702878 @default.
• W3136174586 hasAuthorship W3136174586A5070061845 @default.
• W3136174586 hasAuthorship W3136174586A5090803693 @default.
• W3136174586 hasBestOaLocation W31361745861 @default.
• W3136174586 hasConcept C104317684 @default.
• W3136174586 hasConcept C126322002 @default.
• W3136174586 hasConcept C143998085 @default.
• W3136174586 hasConcept C146357865 @default.
• W3136174586 hasConcept C150194340 @default.
• W3136174586 hasConcept C151730666 @default.
• W3136174586 hasConcept C152110520 @default.
• W3136174586 hasConcept C172680121 @default.
• W3136174586 hasConcept C190727270 @default.
• W3136174586 hasConcept C2777214474 @default.
• W3136174586 hasConcept C2777546739 @default.
• W3136174586 hasConcept C2778019345 @default.
• W3136174586 hasConcept C2778258057 @default.
• W3136174586 hasConcept C2779234561 @default.
• W3136174586 hasConcept C33288867 @default.
• W3136174586 hasConcept C41260117 @default.
• W3136174586 hasConcept C54355233 @default.
• W3136174586 hasConcept C552990157 @default.
• W3136174586 hasConcept C55493867 @default.
• W3136174586 hasConcept C71924100 @default.
• W3136174586 hasConcept C86803240 @default.
• W3136174586 hasConcept C90924648 @default.
• W3136174586 hasConceptScore W3136174586C104317684 @default.
• W3136174586 hasConceptScore W3136174586C126322002 @default.
• W3136174586 hasConceptScore W3136174586C143998085 @default.
• W3136174586 hasConceptScore W3136174586C146357865 @default.
• W3136174586 hasConceptScore W3136174586C150194340 @default.
• W3136174586 hasConceptScore W3136174586C151730666 @default.
• W3136174586 hasConceptScore W3136174586C152110520 @default.
• W3136174586 hasConceptScore W3136174586C172680121 @default.
• W3136174586 hasConceptScore W3136174586C190727270 @default.
• W3136174586 hasConceptScore W3136174586C2777214474 @default.
• W3136174586 hasConceptScore W3136174586C2777546739 @default.
• W3136174586 hasConceptScore W3136174586C2778019345 @default.

• next