FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136176876> ?p ?o ?g. }

• W3136176876 abstract "Previous literature has indicated that cyclin-dependent kinase inhibitor 2 A (CDKN2A) is upregulated, while the Protein Inhibitor of Activated STAT1 (PIAS1) is downregulated in the liver tissues of obese mice. The current study aimed to investigate the relationship between CDKN2A and PIAS1 in the lipogenesis of fatty liver disease. In the C57BL/6J db/db mouse model and hepatocyte model of fatty liver, the expression pattern of CDKN2A, PIAS1, Protein arginine methyltransferase 1 (PRMT1) and CASP8 and FADD-like apoptosis regulator (CFLAR) was characterized by RNA quantitative and Western blot analysis. The lipogenesis-related genes (Srebp1c and Fas) in the liver tissues and cells were employed in the assessment of lipogenesis in response to gain- or loss-of-function of CDKN2A, PIAS1, PRMT1, and CFLAR, while triglyceride and fat content were evaluated in relation to fat accumulation. Western blot analysis was conducted to determine c-Jun amino-terminal kinase (JNK) phosphorylation, while the ubiquitination of CFLAR and SUMOylation of PIAS1 was examined by immunoprecipitation. PIAS1 and CFLAR were downregulated, while CDKN2A, PRMT1, and phosphorylation of JNK was elevated in the tissues and cells of the fatty liver models. Our results suggested that CDKN2A enhanced the SUMOylation of PIAS1 to reduce the expression of PIAS1. PRMT1 downregulated CFLAR by triggering its ubiquitination, while CFLAR repressed phosphorylation of JNK. The in vitro and in vivo results indicated that CDKN2A silencing prevented lipogenesis and fat accumulation by impairing the PRMT1-dependent ubiquitination of CFLAR and blocking the phosphorylation of JNK. Taken together, the central observations of our study demonstrate that targeting CDKN2A contributes to the suppression of lipogenesis and fat accumulation in fatty liver disease. The findings of our study highlight the potential of CDKN2A as a promising target against fatty liver." @default.
• W3136176876 created "2021-03-29" @default.
• W3136176876 creator A5038286928 @default.
• W3136176876 creator A5056011397 @default.
• W3136176876 creator A5057165012 @default.
• W3136176876 creator A5057489654 @default.
• W3136176876 creator A5084653105 @default.
• W3136176876 date "2021-03-26" @default.
• W3136176876 modified "2023-09-27" @default.
• W3136176876 title "CDKN2A deregulation in fatty liver disease and its accelerative role in the process of lipogenesis" @default.
• W3136176876 cites W1897974851 @default.
• W3136176876 cites W1930937854 @default.
• W3136176876 cites W2003223749 @default.
• W3136176876 cites W2004409501 @default.
• W3136176876 cites W2007054651 @default.
• W3136176876 cites W2032182879 @default.
• W3136176876 cites W2089353165 @default.
• W3136176876 cites W2095831007 @default.
• W3136176876 cites W2109216839 @default.
• W3136176876 cites W2116672880 @default.
• W3136176876 cites W2145331216 @default.
• W3136176876 cites W2153903661 @default.
• W3136176876 cites W2157204551 @default.
• W3136176876 cites W2158015791 @default.
• W3136176876 cites W2257297310 @default.
• W3136176876 cites W2264277632 @default.
• W3136176876 cites W2282427225 @default.
• W3136176876 cites W2465055443 @default.
• W3136176876 cites W2521574067 @default.
• W3136176876 cites W2589734336 @default.
• W3136176876 cites W2624997514 @default.
• W3136176876 cites W2765852295 @default.
• W3136176876 cites W2775297519 @default.
• W3136176876 cites W2785779482 @default.
• W3136176876 cites W2793611070 @default.
• W3136176876 cites W2807709055 @default.
• W3136176876 cites W2915144311 @default.
• W3136176876 cites W2920257904 @default.
• W3136176876 cites W2940657120 @default.
• W3136176876 cites W2975077252 @default.
• W3136176876 doi "https://doi.org/10.1096/fj.202000683r" @default.
• W3136176876 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33769609" @default.
• W3136176876 hasPublicationYear "2021" @default.
• W3136176876 type Work @default.
• W3136176876 sameAs 3136176876 @default.
• W3136176876 citedByCount "6" @default.
• W3136176876 countsByYear W31361768762022 @default.
• W3136176876 countsByYear W31361768762023 @default.
• W3136176876 crossrefType "journal-article" @default.
• W3136176876 hasAuthorship W3136176876A5038286928 @default.
• W3136176876 hasAuthorship W3136176876A5056011397 @default.
• W3136176876 hasAuthorship W3136176876A5057165012 @default.
• W3136176876 hasAuthorship W3136176876A5057489654 @default.
• W3136176876 hasAuthorship W3136176876A5084653105 @default.
• W3136176876 hasConcept C126322002 @default.
• W3136176876 hasConcept C141359234 @default.
• W3136176876 hasConcept C162324750 @default.
• W3136176876 hasConcept C185592680 @default.
• W3136176876 hasConcept C2778772119 @default.
• W3136176876 hasConcept C2779134260 @default.
• W3136176876 hasConcept C34447519 @default.
• W3136176876 hasConcept C4733338 @default.
• W3136176876 hasConcept C71924100 @default.
• W3136176876 hasConcept C78780426 @default.
• W3136176876 hasConceptScore W3136176876C126322002 @default.
• W3136176876 hasConceptScore W3136176876C141359234 @default.
• W3136176876 hasConceptScore W3136176876C162324750 @default.
• W3136176876 hasConceptScore W3136176876C185592680 @default.
• W3136176876 hasConceptScore W3136176876C2778772119 @default.
• W3136176876 hasConceptScore W3136176876C2779134260 @default.
• W3136176876 hasConceptScore W3136176876C34447519 @default.
• W3136176876 hasConceptScore W3136176876C4733338 @default.
• W3136176876 hasConceptScore W3136176876C71924100 @default.
• W3136176876 hasConceptScore W3136176876C78780426 @default.
• W3136176876 hasIssue "4" @default.
• W3136176876 hasLocation W31361768761 @default.
• W3136176876 hasOpenAccess W3136176876 @default.
• W3136176876 hasPrimaryLocation W31361768761 @default.
• W3136176876 hasRelatedWork W197196597 @default.
• W3136176876 hasRelatedWork W1972831620 @default.
• W3136176876 hasRelatedWork W1992393423 @default.
• W3136176876 hasRelatedWork W2015867011 @default.
• W3136176876 hasRelatedWork W2044013713 @default.
• W3136176876 hasRelatedWork W2061287523 @default.
• W3136176876 hasRelatedWork W2076965288 @default.
• W3136176876 hasRelatedWork W2144650717 @default.
• W3136176876 hasRelatedWork W2465687240 @default.
• W3136176876 hasRelatedWork W2526211282 @default.
• W3136176876 hasVolume "35" @default.
• W3136176876 isParatext "false" @default.
• W3136176876 isRetracted "false" @default.
• W3136176876 magId "3136176876" @default.
• W3136176876 workType "article" @default.