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- W3136178419 endingPage "736633" @default.
- W3136178419 startingPage "736633" @default.
- W3136178419 abstract "The present study aimed to understand titanium dioxide nanoparticle (TiO2-NPs) induced changes in selected hormones of hypothalamic-pituitary-thyroid/gonad axis in adult females of Labeo rohita, as well as the possible ameliorative role of dietary vitamin E and folic acid. Firstly, adult females of Labeo rohita were injected intraperitoneally with two sublethal doses (1/50 LD50; 10.6 μg kg−1 and 1/10 LD50; 52.8 μg kg−1) of TiO2-NPs and the effect in terms of gonadosomatic index, reproductive & thyroid hormones, vitellogenin, and cortisol were assessed after 21 days of exposure. Subsequently, TiO2-NPs pre-exposed fish were supplemented with vitamin E and folic acid in different combinations for 30 days. The control diet fulfilled the minimum requirement, while two higher doses of vitamin E (200 and 250 mg/kg diet) and folic acid (3 and 4 mg/kg diet) were used in experimental diets. The results showed significant alteration of gonadotropins (an increase of FSH and LH), thyroid hormones (an increase of T3 and T4 without substantial change in TSH), cortisol, steroid hormones, and vitellogenin, upon TiO2-NPs exposure. Among the steroid hormones, testosterone and progesterone levels declined significantly with a concomitant increase in estradiol. More precisely, exposure to 52.8 μg kg−1 TiO2-NPs increased serum estradiol and cortisol to the extent of 98% and 77%, respectively. While serum vitellogenin in Labeo rohita exposed to low and high doses of TiO2-NPs decreased by 29% and 58%, respectively, indicating the adverse effect of TiO2-NPs on reproduction. Dietary administration of vitamin E and folic acid reduced oxidative stress as characterized by lowered antioxidative enzyme's activities. Further, most of the harmful effects of TiO2-NPs were ameliorated by dietary fortification of vitamin E and folic acid, with vitamin E having more pronounced effect." @default.
- W3136178419 created "2021-03-29" @default.
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- W3136178419 date "2021-06-01" @default.
- W3136178419 modified "2023-09-26" @default.
- W3136178419 title "Titanium dioxide nanoparticles alter reproductive and thyroid hormones of Labeo rohita females: Amelioration through vitamin E and folic acid" @default.
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- W3136178419 doi "https://doi.org/10.1016/j.aquaculture.2021.736633" @default.
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