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- W3136179604 abstract "The mesencephalic trigeminal nucleus (Me5) is a unique brain structure that plays a crucial role in orofacial proprioception, and receives synaptic input from various brainstem regions regulating feeding behavior. It is composed mainly of large pseudounipolar neurons, which are glutamatergic, and a subset of smaller multipolar cells of GABAergic nature. Evidence shows that cannabinoid (CB) receptors and their endogenous ligands are widely distributed in brainstem areas that are involved in pain sensation and feeding by influencing the glutamate and GABA neurotransmitter systems. This study aims at investigating the presence of a CB1 receptor, the major cannabinoid receptor subtype in the brain, in Me5 neurons after acute exposure to thermal stress, and pretreatment with its selective agonists and antagonists. We found that the administration of the endogenous CB1 agonist anandamide evokes an intense expression of CB1 receptors in the mesencephalic trigeminal neurons in rats exposed to short-term (up to 1 hour) thermal stress at 32-36°C, while injecting the synthetic CB1 antagonist AM251 decreases the levels of protein expression of this receptor in a hot-plate test. Our results provide immunohistochemical evidence that mild thermal stress triggers endocannabinoid release in a subset of Me5 neurons which utilize glutamate and GABA for synaptic transmission but lack CB1 receptor expression under normal conditions. These findings suggest a possible role for the Me5 endocannabinoid system in providing additional control to the complex neural network which modulates feeding in response to pain-triggering stimuli." @default.
- W3136179604 created "2021-03-29" @default.
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- W3136179604 date "2017-10-10" @default.
- W3136179604 modified "2023-09-23" @default.
- W3136179604 title "Influence of thermal stress on the expression of CB1 cannabinoid receptors in the rat mesencephalic trigeminal nucleus" @default.
- W3136179604 doi "https://doi.org/10.14748/ssm.v49i0.4848" @default.
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