Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136188415> ?p ?o ?g. }
- W3136188415 endingPage "369" @default.
- W3136188415 startingPage "369" @default.
- W3136188415 abstract "Amyotrophic lateral sclerosis (ALS) is a devastating and fatal neurodegenerative disease arising from the combined degeneration of upper motor neurons (UMN) in the motor cortex, and lower motor neurons (LMN) in the brainstem and spinal cord. This dual impairment raises two major questions: (i) are the degenerations of these two neuronal populations somatotopically related? and if yes (ii), where does neurodegeneration start? If studies carried out on ALS patients clearly demonstrated the somatotopic relationship between UMN and LMN degenerations, their temporal relationship remained an unanswered question. In the present study, we took advantage of the well-described Sod1G86R model of ALS to interrogate the somatotopic and temporal relationships between UMN and LMN degenerations in ALS. Using retrograde labelling from the cervical or lumbar spinal cord of Sod1G86R mice and controls to identify UMN, along with electrophysiology and histology to assess LMN degeneration, we applied rigorous sampling, counting, and statistical analyses, and show that UMN and LMN degenerations are somatotopically related and that UMN depletion precedes LMN degeneration. Together, the data indicate that UMN degeneration is a particularly early and thus relevant event in ALS, in accordance with a possible cortical origin of the disease, and emphasize the need to further elucidate the molecular mechanisms behind UMN degeneration, towards new therapeutic avenues." @default.
- W3136188415 created "2021-03-29" @default.
- W3136188415 creator A5001767032 @default.
- W3136188415 creator A5017201051 @default.
- W3136188415 creator A5037412393 @default.
- W3136188415 creator A5080557509 @default.
- W3136188415 creator A5082536763 @default.
- W3136188415 date "2021-03-13" @default.
- W3136188415 modified "2023-09-27" @default.
- W3136188415 title "Upper and Lower Motor Neuron Degenerations Are Somatotopically Related and Temporally Ordered in the Sod1 Mouse Model of Amyotrophic Lateral Sclerosis" @default.
- W3136188415 cites W1503916499 @default.
- W3136188415 cites W1833846911 @default.
- W3136188415 cites W1971541410 @default.
- W3136188415 cites W1980723037 @default.
- W3136188415 cites W1995963457 @default.
- W3136188415 cites W2014739853 @default.
- W3136188415 cites W2014898107 @default.
- W3136188415 cites W2033234578 @default.
- W3136188415 cites W2035022202 @default.
- W3136188415 cites W2039145358 @default.
- W3136188415 cites W2040891140 @default.
- W3136188415 cites W2049937494 @default.
- W3136188415 cites W2070243481 @default.
- W3136188415 cites W2078782799 @default.
- W3136188415 cites W2084009054 @default.
- W3136188415 cites W2088009451 @default.
- W3136188415 cites W2098526078 @default.
- W3136188415 cites W2098540744 @default.
- W3136188415 cites W2112921076 @default.
- W3136188415 cites W2340195634 @default.
- W3136188415 cites W2561785351 @default.
- W3136188415 cites W2613261698 @default.
- W3136188415 cites W2792402131 @default.
- W3136188415 cites W2800454843 @default.
- W3136188415 cites W2888903226 @default.
- W3136188415 cites W2898648053 @default.
- W3136188415 cites W2948061631 @default.
- W3136188415 cites W2991681082 @default.
- W3136188415 cites W2996810109 @default.
- W3136188415 cites W2997020660 @default.
- W3136188415 cites W3023397682 @default.
- W3136188415 cites W3033486727 @default.
- W3136188415 cites W3034958546 @default.
- W3136188415 cites W3037359031 @default.
- W3136188415 cites W3112635102 @default.
- W3136188415 doi "https://doi.org/10.3390/brainsci11030369" @default.
- W3136188415 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7998935" @default.
- W3136188415 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33805792" @default.
- W3136188415 hasPublicationYear "2021" @default.
- W3136188415 type Work @default.
- W3136188415 sameAs 3136188415 @default.
- W3136188415 citedByCount "11" @default.
- W3136188415 countsByYear W31361884152021 @default.
- W3136188415 countsByYear W31361884152022 @default.
- W3136188415 countsByYear W31361884152023 @default.
- W3136188415 crossrefType "journal-article" @default.
- W3136188415 hasAuthorship W3136188415A5001767032 @default.
- W3136188415 hasAuthorship W3136188415A5017201051 @default.
- W3136188415 hasAuthorship W3136188415A5037412393 @default.
- W3136188415 hasAuthorship W3136188415A5080557509 @default.
- W3136188415 hasAuthorship W3136188415A5082536763 @default.
- W3136188415 hasBestOaLocation W31361884151 @default.
- W3136188415 hasConcept C142724271 @default.
- W3136188415 hasConcept C15744967 @default.
- W3136188415 hasConcept C169760540 @default.
- W3136188415 hasConcept C2776752467 @default.
- W3136188415 hasConcept C2776925932 @default.
- W3136188415 hasConcept C2777373429 @default.
- W3136188415 hasConcept C2777615887 @default.
- W3136188415 hasConcept C2779134260 @default.
- W3136188415 hasConcept C2779354088 @default.
- W3136188415 hasConcept C2780596555 @default.
- W3136188415 hasConcept C2780775167 @default.
- W3136188415 hasConcept C2781354215 @default.
- W3136188415 hasConcept C551621295 @default.
- W3136188415 hasConcept C71924100 @default.
- W3136188415 hasConceptScore W3136188415C142724271 @default.
- W3136188415 hasConceptScore W3136188415C15744967 @default.
- W3136188415 hasConceptScore W3136188415C169760540 @default.
- W3136188415 hasConceptScore W3136188415C2776752467 @default.
- W3136188415 hasConceptScore W3136188415C2776925932 @default.
- W3136188415 hasConceptScore W3136188415C2777373429 @default.
- W3136188415 hasConceptScore W3136188415C2777615887 @default.
- W3136188415 hasConceptScore W3136188415C2779134260 @default.
- W3136188415 hasConceptScore W3136188415C2779354088 @default.
- W3136188415 hasConceptScore W3136188415C2780596555 @default.
- W3136188415 hasConceptScore W3136188415C2780775167 @default.
- W3136188415 hasConceptScore W3136188415C2781354215 @default.
- W3136188415 hasConceptScore W3136188415C551621295 @default.
- W3136188415 hasConceptScore W3136188415C71924100 @default.
- W3136188415 hasFunder F4320309751 @default.
- W3136188415 hasFunder F4320334678 @default.
- W3136188415 hasFunder F4320338337 @default.
- W3136188415 hasIssue "3" @default.
- W3136188415 hasLocation W31361884151 @default.
- W3136188415 hasLocation W31361884152 @default.
- W3136188415 hasLocation W31361884153 @default.
- W3136188415 hasLocation W31361884154 @default.