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- W3136190145 endingPage "75" @default.
- W3136190145 startingPage "61" @default.
- W3136190145 abstract "• Whether NLRP3 inflammasome plays a pathogenic role in IBD or protective remains unknown. • The agents administered to targeting NLRP3 inflammasome might be an effective way to treat IBD. • Naturally sourced medicines offer potential treatments for IBD. Cases of inflammatory bowel disease (IBD), a debilitating intestinal disorder with complex pathological mechanisms, have been increasing in recent years, straining the capacity of healthcare systems. Thus, novel therapeutic targets and innovative agents must be developed. Notably, the NLRP3 inflammasome is upregulated in patients with IBD and/or in animal experimental models. As an innate immune supramolecular assembly, the NLRP3 inflammasome is persistently activated during the pathogenesis of IBD by multiple stimuli. Moreover, this protein complex regulates pro-inflammatory cytokines. Thus, targeting this multiprotein oligomer may offer a feasible way to relieve IBD symptoms and improve clinical outcomes. The mechanisms by which the NLRP3 inflammasome is activated, its role in IBD pathogenesis, and the drugs administered to target this protein complex are reviewed herein. This review establishes that the use of inflammasome-targeting drugs are effective for IBD treatment. Moreover, this review suggests that the value and potential of naturally sourced or derived medicines for IBD treatment must be recognized and appreciated." @default.
- W3136190145 created "2021-03-29" @default.
- W3136190145 creator A5008408701 @default.
- W3136190145 creator A5013210870 @default.
- W3136190145 creator A5036065013 @default.
- W3136190145 creator A5040040696 @default.
- W3136190145 creator A5066539596 @default.
- W3136190145 creator A5069101887 @default.
- W3136190145 creator A5088267604 @default.
- W3136190145 date "2021-08-01" @default.
- W3136190145 modified "2023-10-06" @default.
- W3136190145 title "Biological functions of NLRP3 inflammasome: A therapeutic target in inflammatory bowel disease" @default.
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