FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136193945> ?p ?o ?g. }

• W3136193945 endingPage "7057" @default.
• W3136193945 startingPage "7045" @default.
• W3136193945 abstract "Abstract The evolution of the SARS‐CoV‐2 new variants reported to be 70% more contagious than the earlier one is now spreading fast worldwide. There is an instant need to discover how the new variants interact with the host receptor (ACE2). Among the reported mutations in the Spike glycoprotein of the new variants, three are specific to the receptor‐binding domain (RBD) and required insightful scrutiny for new therapeutic options. These structural evolutions in the RBD domain may impart a critical role to the unique pathogenicity of the SARS‐CoV‐2 new variants. Herein, using structural and biophysical approaches, we explored that the specific mutations in the UK (N501Y), South African (K417N‐E484K‐N501Y), Brazilian (K417T‐E484K‐N501Y), and hypothetical (N501Y‐E484K) variants alter the binding affinity, create new inter‐protein contacts and changes the internal structural dynamics thereby increases the binding and eventually the infectivity. Our investigation highlighted that the South African (K417N‐E484K‐N501Y), Brazilian (K417T‐E484K‐N501Y) variants are more lethal than the UK variant (N501Y). The behavior of the wild type and N501Y is comparable. Free energy calculations further confirmed that increased binding of the spike RBD to the ACE2 is mainly due to the electrostatic contribution. Further, we find that the unusual virulence of this virus is potentially the consequence of Darwinian selection‐driven epistasis in protein evolution. The triple mutants (South African and Brazilian) may pose a serious threat to the efficacy of the already developed vaccine. Our analysis would help to understand the binding and structural dynamics of the new mutations in the RBD domain of the Spike protein and demand further investigation in in vitro and in vivo models to design potential therapeutics against the new variants." @default.
• W3136193945 created "2021-03-29" @default.
• W3136193945 creator A5000745893 @default.
• W3136193945 creator A5007416894 @default.
• W3136193945 creator A5009492388 @default.
• W3136193945 creator A5024367375 @default.
• W3136193945 creator A5042246162 @default.
• W3136193945 creator A5066046509 @default.
• W3136193945 creator A5071411811 @default.
• W3136193945 creator A5078443786 @default.
• W3136193945 date "2021-03-23" @default.
• W3136193945 modified "2023-10-03" @default.
• W3136193945 title "Higher infectivity of the SARS‐CoV‐2 new variants is associated with K417N/T, E484K, and N501Y mutants: An insight from structural data" @default.
• W3136193945 cites W1965410913 @default.
• W3136193945 cites W1982533785 @default.
• W3136193945 cites W1994344551 @default.
• W3136193945 cites W2015147796 @default.
• W3136193945 cites W2015179413 @default.
• W3136193945 cites W2029153773 @default.
• W3136193945 cites W2038532826 @default.
• W3136193945 cites W2100561975 @default.
• W3136193945 cites W2103325328 @default.
• W3136193945 cites W2121507105 @default.
• W3136193945 cites W2123015220 @default.
• W3136193945 cites W2130253098 @default.
• W3136193945 cites W2142868265 @default.
• W3136193945 cites W2153983456 @default.
• W3136193945 cites W2170441710 @default.
• W3136193945 cites W2276752820 @default.
• W3136193945 cites W2313116527 @default.
• W3136193945 cites W2332712348 @default.
• W3136193945 cites W2512372054 @default.
• W3136193945 cites W2513547424 @default.
• W3136193945 cites W2802312498 @default.
• W3136193945 cites W2914280503 @default.
• W3136193945 cites W2946526111 @default.
• W3136193945 cites W2971823592 @default.
• W3136193945 cites W2996992994 @default.
• W3136193945 cites W3001118548 @default.
• W3136193945 cites W3002659854 @default.
• W3136193945 cites W3002893740 @default.
• W3136193945 cites W3003790823 @default.
• W3136193945 cites W3006703916 @default.
• W3136193945 cites W3006746866 @default.
• W3136193945 cites W3008874180 @default.
• W3136193945 cites W3008974951 @default.
• W3136193945 cites W3009335299 @default.
• W3136193945 cites W3010441732 @default.
• W3136193945 cites W3014067025 @default.
• W3136193945 cites W3015190630 @default.
• W3136193945 cites W3016078614 @default.
• W3136193945 cites W3017302293 @default.
• W3136193945 cites W3036090423 @default.
• W3136193945 cites W3038931692 @default.
• W3136193945 cites W3038958209 @default.
• W3136193945 cites W3048584818 @default.
• W3136193945 cites W3081474723 @default.
• W3136193945 cites W3107734713 @default.
• W3136193945 cites W3118790515 @default.
• W3136193945 cites W311927316 @default.
• W3136193945 cites W3119771105 @default.
• W3136193945 cites W3120079728 @default.
• W3136193945 cites W3136193945 @default.
• W3136193945 cites W4241938123 @default.
• W3136193945 cites W2135464465 @default.
• W3136193945 doi "https://doi.org/10.1002/jcp.30367" @default.
• W3136193945 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8251074" @default.
• W3136193945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33755190" @default.
• W3136193945 hasPublicationYear "2021" @default.
• W3136193945 type Work @default.
• W3136193945 sameAs 3136193945 @default.
• W3136193945 citedByCount "260" @default.
• W3136193945 countsByYear W31361939452021 @default.
• W3136193945 countsByYear W31361939452022 @default.
• W3136193945 countsByYear W31361939452023 @default.
• W3136193945 crossrefType "journal-article" @default.
• W3136193945 hasAuthorship W3136193945A5000745893 @default.
• W3136193945 hasAuthorship W3136193945A5007416894 @default.
• W3136193945 hasAuthorship W3136193945A5009492388 @default.
• W3136193945 hasAuthorship W3136193945A5024367375 @default.
• W3136193945 hasAuthorship W3136193945A5042246162 @default.
• W3136193945 hasAuthorship W3136193945A5066046509 @default.
• W3136193945 hasAuthorship W3136193945A5071411811 @default.
• W3136193945 hasAuthorship W3136193945A5078443786 @default.
• W3136193945 hasBestOaLocation W31361939451 @default.
• W3136193945 hasConcept C104317684 @default.
• W3136193945 hasConcept C106358424 @default.
• W3136193945 hasConcept C142724271 @default.
• W3136193945 hasConcept C143065580 @default.
• W3136193945 hasConcept C2522874641 @default.
• W3136193945 hasConcept C2779134260 @default.
• W3136193945 hasConcept C3007834351 @default.
• W3136193945 hasConcept C3008058167 @default.
• W3136193945 hasConcept C501734568 @default.
• W3136193945 hasConcept C524204448 @default.
• W3136193945 hasConcept C54355233 @default.
• W3136193945 hasConcept C60987743 @default.
• W3136193945 hasConcept C71924100 @default.

• next