Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136194887> ?p ?o ?g. }
- W3136194887 abstract "Traumatic brain injury (TBI)-related hypopituitarism has been recognized as a clinical entity for more than a century, with the first case being reported in 1918. However, during the 20 th century hypopituitarism was considered only a rare sequela of TBI. Since 2000 several studies strongly suggest that TBI-mediated pituitary hormones deficiency may be more frequent than previously thought. Growth hormone deficiency (GHD) is the most common abnormality, followed by hypogonadism, hypothyroidism, hypocortisolism, and diabetes insipidus. The pathophysiological mechanisms underlying pituitary damage in TBI patients include a primary injury that may lead to the direct trauma of the hypothalamus or pituitary gland; on the other hand, secondary injuries are mainly related to an interplay of a complex and ongoing cascade of specific molecular/biochemical events. The available data describe the importance of GHD after TBI and its influence in promoting neurocognitive and behavioral deficits. The poor outcomes that are seen with long standing GHD in post TBI patients could be improved by GH treatment, but to date literature data on the possible beneficial effects of GH replacement therapy in post-TBI GHD patients are currently scarce and fragmented. More studies are needed to further characterize this clinical syndrome with the purpose of establishing appropriate standards of care. The purpose of this review is to summarize the current state of knowledge about post-traumatic GH deficiency." @default.
- W3136194887 created "2021-03-29" @default.
- W3136194887 creator A5007907892 @default.
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- W3136194887 creator A5050885469 @default.
- W3136194887 creator A5057537921 @default.
- W3136194887 creator A5072698787 @default.
- W3136194887 date "2021-03-15" @default.
- W3136194887 modified "2023-10-10" @default.
- W3136194887 title "Traumatic Brain Injury as Frequent Cause of Hypopituitarism and Growth Hormone Deficiency: Epidemiology, Diagnosis, and Treatment" @default.
- W3136194887 cites W1546440420 @default.
- W3136194887 cites W1564669112 @default.
- W3136194887 cites W1603121691 @default.
- W3136194887 cites W1663695055 @default.
- W3136194887 cites W170131929 @default.
- W3136194887 cites W1876007594 @default.
- W3136194887 cites W1963875847 @default.
- W3136194887 cites W1966478127 @default.
- W3136194887 cites W1967383091 @default.
- W3136194887 cites W1967507952 @default.
- W3136194887 cites W1968827204 @default.
- W3136194887 cites W1970014778 @default.
- W3136194887 cites W1973015253 @default.
- W3136194887 cites W1974716477 @default.
- W3136194887 cites W1975438987 @default.
- W3136194887 cites W1977236517 @default.
- W3136194887 cites W1977485109 @default.
- W3136194887 cites W1977833857 @default.
- W3136194887 cites W1977878106 @default.
- W3136194887 cites W1981423157 @default.
- W3136194887 cites W1982835579 @default.
- W3136194887 cites W1984943674 @default.
- W3136194887 cites W1985413363 @default.
- W3136194887 cites W1985855615 @default.
- W3136194887 cites W1988757364 @default.
- W3136194887 cites W1989235817 @default.
- W3136194887 cites W1989301603 @default.
- W3136194887 cites W1992622058 @default.
- W3136194887 cites W1994580560 @default.
- W3136194887 cites W1995203150 @default.
- W3136194887 cites W1995465314 @default.
- W3136194887 cites W1998798793 @default.
- W3136194887 cites W2000606158 @default.
- W3136194887 cites W2002163724 @default.
- W3136194887 cites W2003802121 @default.
- W3136194887 cites W2004293379 @default.
- W3136194887 cites W2006134869 @default.
- W3136194887 cites W2006334422 @default.
- W3136194887 cites W2007129533 @default.
- W3136194887 cites W2007898025 @default.
- W3136194887 cites W2009658244 @default.
- W3136194887 cites W2011237935 @default.
- W3136194887 cites W2011960502 @default.
- W3136194887 cites W2014290943 @default.
- W3136194887 cites W2014335049 @default.
- W3136194887 cites W2014547115 @default.
- W3136194887 cites W2017722607 @default.
- W3136194887 cites W2017840530 @default.
- W3136194887 cites W2021968670 @default.
- W3136194887 cites W2022644027 @default.
- W3136194887 cites W2024977477 @default.
- W3136194887 cites W2029809297 @default.
- W3136194887 cites W2032738647 @default.
- W3136194887 cites W2034344832 @default.
- W3136194887 cites W2034623629 @default.
- W3136194887 cites W2034679108 @default.
- W3136194887 cites W2036286877 @default.
- W3136194887 cites W2036449739 @default.
- W3136194887 cites W2036486979 @default.
- W3136194887 cites W2037872455 @default.
- W3136194887 cites W2039148071 @default.
- W3136194887 cites W2041292180 @default.
- W3136194887 cites W2041293559 @default.
- W3136194887 cites W2045273489 @default.
- W3136194887 cites W2047592324 @default.
- W3136194887 cites W2048103562 @default.
- W3136194887 cites W2048128132 @default.
- W3136194887 cites W2049205408 @default.
- W3136194887 cites W2049447069 @default.
- W3136194887 cites W2049502800 @default.
- W3136194887 cites W2049543211 @default.
- W3136194887 cites W2049986534 @default.
- W3136194887 cites W2050915507 @default.
- W3136194887 cites W2053402068 @default.
- W3136194887 cites W2053845533 @default.
- W3136194887 cites W2056415845 @default.
- W3136194887 cites W2058019148 @default.
- W3136194887 cites W2060342056 @default.
- W3136194887 cites W2060450299 @default.
- W3136194887 cites W2060719656 @default.
- W3136194887 cites W2061797923 @default.
- W3136194887 cites W2063972644 @default.
- W3136194887 cites W2065346311 @default.
- W3136194887 cites W2066340447 @default.
- W3136194887 cites W2067743690 @default.
- W3136194887 cites W2069111231 @default.
- W3136194887 cites W2073005435 @default.
- W3136194887 cites W2073266477 @default.
- W3136194887 cites W2075187575 @default.
- W3136194887 cites W2075218265 @default.