Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136198941> ?p ?o ?g. }
- W3136198941 abstract "In human glioblastoma (GBM), the presence of a small population of cells with stem cell characteristics, the glioma stem cells (GSCs), has been described. These cells have GBM potential and are responsible for the origin of the tumors. However, whether GSCs originate from normal neural stem cells (NSCs) as a consequence of genetic and epigenetic changes and/or dedifferentiation from somatic cells remains to be investigated. Genomic imprinting is an epigenetic marking process that causes genes to be expressed depending on their parental origin. The dysregulation of the imprinting pattern or the loss of genomic imprinting (LOI) have been described in different tumors including GBM, being one of the earliest and most common events that occurs in human cancers. Here we have gathered the current knowledge of the role of imprinted genes in normal NSCs function and how the imprinting process is altered in human GBM. We also review the changes at particular imprinted loci that might be involved in the development of the tumor. Understanding the mechanistic similarities in the regulation of genomic imprinting between normal NSCs and GBM cells will be helpful to identify molecular players that might be involved in the development of human GBM." @default.
- W3136198941 created "2021-03-29" @default.
- W3136198941 creator A5005504211 @default.
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- W3136198941 creator A5088455379 @default.
- W3136198941 creator A5089857865 @default.
- W3136198941 creator A5090621410 @default.
- W3136198941 date "2021-03-12" @default.
- W3136198941 modified "2023-10-18" @default.
- W3136198941 title "Aberrations of Genomic Imprinting in Glioblastoma Formation" @default.
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- W3136198941 doi "https://doi.org/10.3389/fonc.2021.630482" @default.
- W3136198941 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7994891" @default.