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- W3136200508 endingPage "5478" @default.
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- W3136200508 abstract "Bacterial multidrug efflux pumps have come to prominence in human and veterinary pathogenesis because they help bacteria protect themselves against the antimicrobials used to overcome their infections. However, it is increasingly realized that many, probably most, such pumps have physiological roles that are distinct from protection of bacteria against antimicrobials administered by humans. Here we undertake a broad survey of the proteins involved, allied to detailed examples of their evolution, energetics, structures, chemical recognition, and molecular mechanisms, together with the experimental strategies that enable rapid and economical progress in understanding their true physiological roles. Once these roles are established, the knowledge can be harnessed to design more effective drugs, improve existing microbial production of drugs for clinical practice and of feedstocks for commercial exploitation, and even develop more sustainable biological processes that avoid, for example, utilization of petroleum." @default.
- W3136200508 created "2021-03-29" @default.
- W3136200508 creator A5022016477 @default.
- W3136200508 creator A5053070696 @default.
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- W3136200508 creator A5061444276 @default.
- W3136200508 creator A5062811599 @default.
- W3136200508 creator A5069669892 @default.
- W3136200508 date "2021-03-24" @default.
- W3136200508 modified "2023-10-12" @default.
- W3136200508 title "Physiological Functions of Bacterial “Multidrug” Efflux Pumps" @default.
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