FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136202012> ?p ?o ?g. }

• W3136202012 endingPage "254" @default.
• W3136202012 startingPage "254" @default.
• W3136202012 abstract "During a specific milk fermentation process with Bifidobacterium breve C50 and Streptococcus thermophilus 065 (LactofidusTM), postbiotics with possible immunomodulatory properties are produced. We investigated the effects of this fermentation product (FP) in vitro using a model that allows crosstalk between intestinal epithelial (IEC) and immune cells. IECs were exposed to FP and αCD3/CD28-activated peripheral blood mononuclear cells after which the mediator secretion was measured. Additionally, using a murine influenza vaccination model, immune development was assessed. Mice were fed an AIN93G diet containing FP or lactose as control. Vaccine-specific immunity was measured as delayed-type hypersensitivity (DTH) and correlated to intestinal and systemic immunomodulation levels. In vitro, exposure to FP enhanced IFNγ, TNFα and IL-17A concentrations. Moreover, IEC-derived galectin-3/galectin-9 and galectin-4/galectin-9 ratios were increased. In vivo, dietary intervention with FP increased vaccine-specific DTH responses as compared to the lactose-receiving group. Although no effects on humoral immunity and vaccine-specific T-cell responses were detected, an enhanced systemic serum galectin-3/galectin-9 and galectin-4/galectin-9 ratio correlated with a shift in RORγ (Th17) mRNA expression over regulatory TGFβ1 in the ileum. This was also positively correlated with the increased DTH response. These results indicate that FP can enhance epithelial galectin-3 and -4 over galectin-9 release, and boost adaptive immunity by promoting Th1- and Th17-type cytokines under inflammatory conditions in vitro. Similar variations in galectin and immune balance were observed in the vaccination model, where FP improved the influenza-specific DTH response." @default.
• W3136202012 created "2021-03-29" @default.
• W3136202012 creator A5000186498 @default.
• W3136202012 creator A5012792362 @default.
• W3136202012 creator A5023267835 @default.
• W3136202012 creator A5038090024 @default.
• W3136202012 creator A5046646171 @default.
• W3136202012 creator A5051105540 @default.
• W3136202012 creator A5069659223 @default.
• W3136202012 creator A5077130644 @default.
• W3136202012 creator A5086027200 @default.
• W3136202012 creator A5090295856 @default.
• W3136202012 date "2021-03-13" @default.
• W3136202012 modified "2023-10-13" @default.
• W3136202012 title "A Fermented Milk Matrix Containing Postbiotics Supports Th1- and Th17-Type Immunity In Vitro and Modulates the Influenza-Specific Vaccination Response In Vivo in Association with Altered Serum Galectin Ratios" @default.
• W3136202012 cites W1956558450 @default.
• W3136202012 cites W1972270983 @default.
• W3136202012 cites W1976800458 @default.
• W3136202012 cites W1979366969 @default.
• W3136202012 cites W1983257114 @default.
• W3136202012 cites W1985997449 @default.
• W3136202012 cites W1995278555 @default.
• W3136202012 cites W1997386937 @default.
• W3136202012 cites W1998008324 @default.
• W3136202012 cites W1999164610 @default.
• W3136202012 cites W2000041349 @default.
• W3136202012 cites W2005441308 @default.
• W3136202012 cites W2006537963 @default.
• W3136202012 cites W2014112293 @default.
• W3136202012 cites W2026363327 @default.
• W3136202012 cites W2031624408 @default.
• W3136202012 cites W2044988027 @default.
• W3136202012 cites W2057180963 @default.
• W3136202012 cites W2070171027 @default.
• W3136202012 cites W2078929498 @default.
• W3136202012 cites W2086006111 @default.
• W3136202012 cites W2087708034 @default.
• W3136202012 cites W2089634605 @default.
• W3136202012 cites W2092094143 @default.
• W3136202012 cites W2092235636 @default.
• W3136202012 cites W2093304828 @default.
• W3136202012 cites W2098380988 @default.
• W3136202012 cites W2106985367 @default.
• W3136202012 cites W2112866067 @default.
• W3136202012 cites W2112902381 @default.
• W3136202012 cites W2129343238 @default.
• W3136202012 cites W2133260339 @default.
• W3136202012 cites W2142017607 @default.
• W3136202012 cites W2145498289 @default.
• W3136202012 cites W2155779547 @default.
• W3136202012 cites W2258385876 @default.
• W3136202012 cites W2267159071 @default.
• W3136202012 cites W2305372638 @default.
• W3136202012 cites W2311196768 @default.
• W3136202012 cites W2522677889 @default.
• W3136202012 cites W2523136766 @default.
• W3136202012 cites W2792983506 @default.
• W3136202012 cites W2793397992 @default.
• W3136202012 cites W2800651075 @default.
• W3136202012 cites W2913158322 @default.
• W3136202012 cites W2954920889 @default.
• W3136202012 cites W2956175090 @default.
• W3136202012 cites W2965180891 @default.
• W3136202012 cites W2973325467 @default.
• W3136202012 cites W2977313709 @default.
• W3136202012 cites W3027207950 @default.
• W3136202012 cites W3039778960 @default.
• W3136202012 doi "https://doi.org/10.3390/vaccines9030254" @default.
• W3136202012 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7998404" @default.
• W3136202012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33805597" @default.
• W3136202012 hasPublicationYear "2021" @default.
• W3136202012 type Work @default.
• W3136202012 sameAs 3136202012 @default.
• W3136202012 citedByCount "6" @default.
• W3136202012 countsByYear W31362020122021 @default.
• W3136202012 countsByYear W31362020122022 @default.
• W3136202012 countsByYear W31362020122023 @default.
• W3136202012 crossrefType "journal-article" @default.
• W3136202012 hasAuthorship W3136202012A5000186498 @default.
• W3136202012 hasAuthorship W3136202012A5012792362 @default.
• W3136202012 hasAuthorship W3136202012A5023267835 @default.
• W3136202012 hasAuthorship W3136202012A5038090024 @default.
• W3136202012 hasAuthorship W3136202012A5046646171 @default.
• W3136202012 hasAuthorship W3136202012A5051105540 @default.
• W3136202012 hasAuthorship W3136202012A5069659223 @default.
• W3136202012 hasAuthorship W3136202012A5077130644 @default.
• W3136202012 hasAuthorship W3136202012A5086027200 @default.
• W3136202012 hasAuthorship W3136202012A5090295856 @default.
• W3136202012 hasBestOaLocation W31362020121 @default.
• W3136202012 hasConcept C150903083 @default.
• W3136202012 hasConcept C156293190 @default.
• W3136202012 hasConcept C203014093 @default.
• W3136202012 hasConcept C207001950 @default.
• W3136202012 hasConcept C22070199 @default.
• W3136202012 hasConcept C2779341262 @default.
• W3136202012 hasConcept C71924100 @default.
• W3136202012 hasConcept C86803240 @default.
• W3136202012 hasConcept C8891405 @default.

• next