Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136204380> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W3136204380 endingPage "41" @default.
- W3136204380 startingPage "2" @default.
- W3136204380 abstract "O-GlcNAcylation is a dynamic post-translational modification of cytonuclear molecules and regulated by only two enzymes, OGT and OGA, which add and remove a glucose metabolite, UDP-GlcNAc, respectively. Previously, we reported that augmented O-GlcNAcylation increased the expression of FOXM1, which is an oncogenic transcription factor and overexpressed in various cancers, by reducing its ubiquitination (Ub). Here, we examined the O-GlcNAcylation-mediated regulation of FOXM1 expression through FBXL2 E3 ligase and USP22 deubiquitinase. FOXM1 Ub was regulated by the two enzymes and, interestingly, FBXL2 itself was ubiquitinated, which was promoted by an OGA inhibitor (Thiamet G, TMG) treatment, accompanying with elevated FBXL2 O-GlcNAcylation. Moreover, FBXL2 induction using the Tet-on system showed that FOXM1 expression and cell proliferation were reduced, while those were attenuated by TMG treatment or USP22 induction in NUGC-3 cells. These data suggest that elevated O-GlcNAcylation might contribute to FOXM1 overexpression by regulating its Ub in various cancers. Because FOXM1 or USP22 was reported not only to be elevated in the various clinical cancers but also to be involved in drug resistance. So now, we are going to evaluate the combination treatment of anticancer drugs with the inhibitor of FOXM1 or OGT in NUGC-3 cells." @default.
- W3136204380 created "2021-03-29" @default.
- W3136204380 creator A5003224539 @default.
- W3136204380 creator A5016903737 @default.
- W3136204380 creator A5060924929 @default.
- W3136204380 creator A5063797243 @default.
- W3136204380 creator A5088154202 @default.
- W3136204380 date "2021-01-01" @default.
- W3136204380 modified "2023-10-01" @default.
- W3136204380 title "<i>O</i>-GlcNAcylation-mediated regulation of FOXM1 expression through its ubiquitination in a human gastric adenocarcinoma cell line, NUGC-3" @default.
- W3136204380 doi "https://doi.org/10.1254/jpssuppl.94.0_2-p2-41" @default.
- W3136204380 hasPublicationYear "2021" @default.
- W3136204380 type Work @default.
- W3136204380 sameAs 3136204380 @default.
- W3136204380 citedByCount "0" @default.
- W3136204380 crossrefType "journal-article" @default.
- W3136204380 hasAuthorship W3136204380A5003224539 @default.
- W3136204380 hasAuthorship W3136204380A5016903737 @default.
- W3136204380 hasAuthorship W3136204380A5060924929 @default.
- W3136204380 hasAuthorship W3136204380A5063797243 @default.
- W3136204380 hasAuthorship W3136204380A5088154202 @default.
- W3136204380 hasBestOaLocation W31362043801 @default.
- W3136204380 hasConcept C102658986 @default.
- W3136204380 hasConcept C104317684 @default.
- W3136204380 hasConcept C134459356 @default.
- W3136204380 hasConcept C170240278 @default.
- W3136204380 hasConcept C173396325 @default.
- W3136204380 hasConcept C185592680 @default.
- W3136204380 hasConcept C25602115 @default.
- W3136204380 hasConcept C502942594 @default.
- W3136204380 hasConcept C54355233 @default.
- W3136204380 hasConcept C55493867 @default.
- W3136204380 hasConcept C81885089 @default.
- W3136204380 hasConcept C86339819 @default.
- W3136204380 hasConcept C86803240 @default.
- W3136204380 hasConcept C95444343 @default.
- W3136204380 hasConceptScore W3136204380C102658986 @default.
- W3136204380 hasConceptScore W3136204380C104317684 @default.
- W3136204380 hasConceptScore W3136204380C134459356 @default.
- W3136204380 hasConceptScore W3136204380C170240278 @default.
- W3136204380 hasConceptScore W3136204380C173396325 @default.
- W3136204380 hasConceptScore W3136204380C185592680 @default.
- W3136204380 hasConceptScore W3136204380C25602115 @default.
- W3136204380 hasConceptScore W3136204380C502942594 @default.
- W3136204380 hasConceptScore W3136204380C54355233 @default.
- W3136204380 hasConceptScore W3136204380C55493867 @default.
- W3136204380 hasConceptScore W3136204380C81885089 @default.
- W3136204380 hasConceptScore W3136204380C86339819 @default.
- W3136204380 hasConceptScore W3136204380C86803240 @default.
- W3136204380 hasConceptScore W3136204380C95444343 @default.
- W3136204380 hasIssue "0" @default.
- W3136204380 hasLocation W31362043801 @default.
- W3136204380 hasOpenAccess W3136204380 @default.
- W3136204380 hasPrimaryLocation W31362043801 @default.
- W3136204380 hasRelatedWork W2034173685 @default.
- W3136204380 hasRelatedWork W2090453777 @default.
- W3136204380 hasRelatedWork W2095693152 @default.
- W3136204380 hasRelatedWork W2144449542 @default.
- W3136204380 hasRelatedWork W3011679002 @default.
- W3136204380 hasRelatedWork W3045792355 @default.
- W3136204380 hasRelatedWork W3204860597 @default.
- W3136204380 hasRelatedWork W4221130740 @default.
- W3136204380 hasRelatedWork W4285732750 @default.
- W3136204380 hasRelatedWork W4309951903 @default.
- W3136204380 hasVolume "94" @default.
- W3136204380 isParatext "false" @default.
- W3136204380 isRetracted "false" @default.
- W3136204380 magId "3136204380" @default.
- W3136204380 workType "article" @default.