FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136205144> ?p ?o ?g. }

• W3136205144 endingPage "110" @default.
• W3136205144 startingPage "102" @default.
• W3136205144 abstract "Acute myocardial infarction (AMI) has been a devastating actuality and accounts for half of cardiovascular emergency department visits. Nucleotide oligomerization domain, leucine-rich repeat, and pyrin domain-containing protein 3 (NLRP3) inflammasome participates in the mediation of myocardial inflammation during AMI. Therefore, this study aimed to reveal the therapeutic function of tranilast, an agent targeting NLRP3, for AMI. AMI mouse model was first established by transient myocardial ischemia. Western blot and quantitative reverse transcription polymerase chain reaction assay were performed to estimate the expression levels of related genes. Flow cytometry was used to analyze the macrophage types, and the therapeutic effects of tranilast were estimated by echocardiographic analysis and Masson's trichrome stain. We demonstrated that AMI induced the activation of NLRP3 inflammasome in the heart tissues of mice with AMI. Tranilast decreased the expression of interleukin-1β and cleaved caspase-1 in bone marrow-derived macrophages and thus re-educated M1-macrophages toward the M2-phenotype both in vitro and in vivo. Tranilast inhibited the activation in the heart tissues of AMI mice and thus improved cardiac functional recovery in the AMI mouse model. In conclusion, we revealed that tranilast ameliorated myocardial infarction by inhibiting NLRP3 inflammasome and re-educating macrophage phenotype in this study." @default.
• W3136205144 created "2021-03-29" @default.
• W3136205144 creator A5042565416 @default.
• W3136205144 creator A5049687528 @default.
• W3136205144 creator A5076222222 @default.
• W3136205144 date "2021-03-01" @default.
• W3136205144 modified "2023-09-27" @default.
• W3136205144 title "Effects of Tranilast on Inflammasome and Macrophage Phenotype in a Mouse Model of Myocardial Infarction" @default.
• W3136205144 cites W2010239439 @default.
• W3136205144 cites W2015740839 @default.
• W3136205144 cites W2056978331 @default.
• W3136205144 cites W2058897432 @default.
• W3136205144 cites W2075529906 @default.
• W3136205144 cites W2126736385 @default.
• W3136205144 cites W2145190952 @default.
• W3136205144 cites W2158380859 @default.
• W3136205144 cites W2181500365 @default.
• W3136205144 cites W2264171839 @default.
• W3136205144 cites W2601186451 @default.
• W3136205144 cites W2623650805 @default.
• W3136205144 cites W2754665187 @default.
• W3136205144 cites W2765107128 @default.
• W3136205144 cites W2768492618 @default.
• W3136205144 cites W2780992935 @default.
• W3136205144 cites W2790572647 @default.
• W3136205144 cites W2793011605 @default.
• W3136205144 cites W2796313978 @default.
• W3136205144 cites W2804243706 @default.
• W3136205144 cites W2905827542 @default.
• W3136205144 cites W2907519640 @default.
• W3136205144 cites W2970906420 @default.
• W3136205144 cites W2972954036 @default.
• W3136205144 cites W2981732606 @default.
• W3136205144 cites W3000586923 @default.
• W3136205144 cites W3011498806 @default.
• W3136205144 cites W3013105783 @default.
• W3136205144 cites W3017541832 @default.
• W3136205144 cites W3030086505 @default.
• W3136205144 cites W3041445210 @default.
• W3136205144 cites W3109521801 @default.
• W3136205144 cites W3111080910 @default.
• W3136205144 cites W3112310683 @default.
• W3136205144 cites W3115435253 @default.
• W3136205144 cites W3120688948 @default.
• W3136205144 doi "https://doi.org/10.1089/jir.2020.0208" @default.
• W3136205144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33750216" @default.
• W3136205144 hasPublicationYear "2021" @default.
• W3136205144 type Work @default.
• W3136205144 sameAs 3136205144 @default.
• W3136205144 citedByCount "2" @default.
• W3136205144 countsByYear W31362051442022 @default.
• W3136205144 countsByYear W31362051442023 @default.
• W3136205144 crossrefType "journal-article" @default.
• W3136205144 hasAuthorship W3136205144A5042565416 @default.
• W3136205144 hasAuthorship W3136205144A5049687528 @default.
• W3136205144 hasAuthorship W3136205144A5076222222 @default.
• W3136205144 hasConcept C104317684 @default.
• W3136205144 hasConcept C126322002 @default.
• W3136205144 hasConcept C139174496 @default.
• W3136205144 hasConcept C150903083 @default.
• W3136205144 hasConcept C185592680 @default.
• W3136205144 hasConcept C202751555 @default.
• W3136205144 hasConcept C203014093 @default.
• W3136205144 hasConcept C207001950 @default.
• W3136205144 hasConcept C2776415932 @default.
• W3136205144 hasConcept C2776914184 @default.
• W3136205144 hasConcept C2777209026 @default.
• W3136205144 hasConcept C2779244956 @default.
• W3136205144 hasConcept C2780269026 @default.
• W3136205144 hasConcept C500558357 @default.
• W3136205144 hasConcept C55493867 @default.
• W3136205144 hasConcept C71924100 @default.
• W3136205144 hasConcept C86803240 @default.
• W3136205144 hasConcept C98274493 @default.
• W3136205144 hasConceptScore W3136205144C104317684 @default.
• W3136205144 hasConceptScore W3136205144C126322002 @default.
• W3136205144 hasConceptScore W3136205144C139174496 @default.
• W3136205144 hasConceptScore W3136205144C150903083 @default.
• W3136205144 hasConceptScore W3136205144C185592680 @default.
• W3136205144 hasConceptScore W3136205144C202751555 @default.
• W3136205144 hasConceptScore W3136205144C203014093 @default.
• W3136205144 hasConceptScore W3136205144C207001950 @default.
• W3136205144 hasConceptScore W3136205144C2776415932 @default.
• W3136205144 hasConceptScore W3136205144C2776914184 @default.
• W3136205144 hasConceptScore W3136205144C2777209026 @default.
• W3136205144 hasConceptScore W3136205144C2779244956 @default.
• W3136205144 hasConceptScore W3136205144C2780269026 @default.
• W3136205144 hasConceptScore W3136205144C500558357 @default.
• W3136205144 hasConceptScore W3136205144C55493867 @default.
• W3136205144 hasConceptScore W3136205144C71924100 @default.
• W3136205144 hasConceptScore W3136205144C86803240 @default.
• W3136205144 hasConceptScore W3136205144C98274493 @default.
• W3136205144 hasIssue "3" @default.
• W3136205144 hasLocation W31362051441 @default.
• W3136205144 hasLocation W31362051442 @default.
• W3136205144 hasOpenAccess W3136205144 @default.
• W3136205144 hasPrimaryLocation W31362051441 @default.
• W3136205144 hasRelatedWork W1508245019 @default.

• next