Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136211210> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W3136211210 endingPage "561" @default.
- W3136211210 startingPage "555" @default.
- W3136211210 abstract "Alzheimer's disease (AD), the most prevalent dementia, is identified as a neurodegenerative disease arising from a degenerative disturbance in the central nervous system. A previous study reported that TTP488 could ameliorate symptoms in patients with mild AD, but the underlying mechanisms need to be studied further. Therefore, the objective of this study was to explore the role of TTP488 in the development of an AD cell model. Administration of TTP448 in an AD cell model reduced the expression of pro‐inflammatory cytokines [interleukin (IL)‐1β, IL‐6, and TNF‐α], reversed the inhibitory role of Aβ on cell proliferation and viability, and decreased Aβ‐triggered cell apoptosis and reactive oxygen species (ROS) production. Furthermore, Aβ treatment induced activation of JAK1/STAT3/NFκB/IRF3 pathway as well as NLRP3 expression, and TTP488 administration partially reversed the activation of this pathway and NLRP3 expression. Use of WP1160, a STAT3 agonist, re‐activated the downstream STAT3/NFκB/IRF3 pathway and NLRP3 expression. Moreover, we found that WP1160 counteracted the role of TTP488 in Aβ‐induced SH‐SY5Y cells' viability, inflammation, apoptosis, and ROS production. Significance of the study This study explores the role of TTP488 in the development of an Alzheimer's disease (AD) cell model and confirms that TTP488 administration notably promotes cell proliferation and reduces apoptosis, inflammatory factor expression, and reactive oxygen species generation. Further, this study suggests that the NLRP3‐relevant JAK1/STAT3/P65/IRF3 signalling pathway is related to AD pathogenesis." @default.
- W3136211210 created "2021-03-29" @default.
- W3136211210 creator A5001325376 @default.
- W3136211210 creator A5014294522 @default.
- W3136211210 creator A5030446424 @default.
- W3136211210 creator A5084121229 @default.
- W3136211210 date "2021-03-16" @default.
- W3136211210 modified "2023-10-17" @default.
- W3136211210 title "<scp>TTP488</scp> ameliorates <scp>NLRP3</scp>‐associated inflammation, viability, apoptosis, and <scp>ROS</scp> production in an Alzheimer's disease cell model by mediating the <scp>JAK1</scp>/<scp>STAT3</scp>/<scp>NFκB</scp>/<scp>IRF3</scp> pathway" @default.
- W3136211210 cites W1483432124 @default.
- W3136211210 cites W1970028828 @default.
- W3136211210 cites W1984503507 @default.
- W3136211210 cites W1993976394 @default.
- W3136211210 cites W1996312756 @default.
- W3136211210 cites W2014504691 @default.
- W3136211210 cites W2023241993 @default.
- W3136211210 cites W2028174194 @default.
- W3136211210 cites W2034915046 @default.
- W3136211210 cites W2041624512 @default.
- W3136211210 cites W2043091577 @default.
- W3136211210 cites W2047664476 @default.
- W3136211210 cites W2052593121 @default.
- W3136211210 cites W2058803210 @default.
- W3136211210 cites W2065403797 @default.
- W3136211210 cites W2093629582 @default.
- W3136211210 cites W2114769428 @default.
- W3136211210 cites W2116867438 @default.
- W3136211210 cites W2118403357 @default.
- W3136211210 cites W2119098586 @default.
- W3136211210 cites W2120302366 @default.
- W3136211210 cites W2126402425 @default.
- W3136211210 cites W2159394172 @default.
- W3136211210 cites W2168334242 @default.
- W3136211210 cites W2171420547 @default.
- W3136211210 cites W2582624056 @default.
- W3136211210 cites W2747668522 @default.
- W3136211210 doi "https://doi.org/10.1002/cbf.3623" @default.
- W3136211210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33724512" @default.
- W3136211210 hasPublicationYear "2021" @default.
- W3136211210 type Work @default.
- W3136211210 sameAs 3136211210 @default.
- W3136211210 citedByCount "7" @default.
- W3136211210 countsByYear W31362112102022 @default.
- W3136211210 countsByYear W31362112102023 @default.
- W3136211210 crossrefType "journal-article" @default.
- W3136211210 hasAuthorship W3136211210A5001325376 @default.
- W3136211210 hasAuthorship W3136211210A5014294522 @default.
- W3136211210 hasAuthorship W3136211210A5030446424 @default.
- W3136211210 hasAuthorship W3136211210A5084121229 @default.
- W3136211210 hasConcept C185592680 @default.
- W3136211210 hasConcept C190283241 @default.
- W3136211210 hasConcept C203014093 @default.
- W3136211210 hasConcept C2778923194 @default.
- W3136211210 hasConcept C48349386 @default.
- W3136211210 hasConcept C502942594 @default.
- W3136211210 hasConcept C53227056 @default.
- W3136211210 hasConcept C55493867 @default.
- W3136211210 hasConcept C62478195 @default.
- W3136211210 hasConcept C86803240 @default.
- W3136211210 hasConcept C95444343 @default.
- W3136211210 hasConceptScore W3136211210C185592680 @default.
- W3136211210 hasConceptScore W3136211210C190283241 @default.
- W3136211210 hasConceptScore W3136211210C203014093 @default.
- W3136211210 hasConceptScore W3136211210C2778923194 @default.
- W3136211210 hasConceptScore W3136211210C48349386 @default.
- W3136211210 hasConceptScore W3136211210C502942594 @default.
- W3136211210 hasConceptScore W3136211210C53227056 @default.
- W3136211210 hasConceptScore W3136211210C55493867 @default.
- W3136211210 hasConceptScore W3136211210C62478195 @default.
- W3136211210 hasConceptScore W3136211210C86803240 @default.
- W3136211210 hasConceptScore W3136211210C95444343 @default.
- W3136211210 hasIssue "4" @default.
- W3136211210 hasLocation W31362112101 @default.
- W3136211210 hasOpenAccess W3136211210 @default.
- W3136211210 hasPrimaryLocation W31362112101 @default.
- W3136211210 hasRelatedWork W2135807798 @default.
- W3136211210 hasRelatedWork W2322345108 @default.
- W3136211210 hasRelatedWork W2380755462 @default.
- W3136211210 hasRelatedWork W2471519923 @default.
- W3136211210 hasRelatedWork W2755853517 @default.
- W3136211210 hasRelatedWork W2999764131 @default.
- W3136211210 hasRelatedWork W3141490158 @default.
- W3136211210 hasRelatedWork W3148810057 @default.
- W3136211210 hasRelatedWork W3150682115 @default.
- W3136211210 hasRelatedWork W3152233030 @default.
- W3136211210 hasVolume "39" @default.
- W3136211210 isParatext "false" @default.
- W3136211210 isRetracted "false" @default.
- W3136211210 magId "3136211210" @default.
- W3136211210 workType "article" @default.