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• W3136221353 startingPage "734" @default.
• W3136221353 abstract "Duck Tembusu virus (DTMUV), a neurotropic flavivirus, is a causative agent of severe neurological diseases in different birds. No approved vaccines or antiviral therapeutic treatments are available to date. The poultry industry experiences significant economic losses due to DTMUV infections. Minocycline is a second-generation semi-synthetic tetracycline analogue that is commonly used as an antimicrobial treatment. Experimental studies have indicated the successful protective effects of minocycline against neuronal cell death from neurodegenerative diseases and viral encephalitis. The aim of this study was to investigate the effects of minocycline on DTMUV infection in neurons. Primary duck neurons were treated with minocycline, which exhibited neuroprotective effects via anti-apoptotic function rather than through viral replication inhibition. Minocycline might serve as a potential effective drug in DTMUV infection." @default.
• W3136221353 created "2021-03-29" @default.
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• W3136221353 date "2021-01-01" @default.
• W3136221353 modified "2023-10-12" @default.
• W3136221353 title "Minocycline prevents primary duck neurons from duck Tembusu virus-induced death" @default.
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• W3136221353 doi "https://doi.org/10.1292/jvms.20-0735" @default.
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