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- W3136222580 abstract "Abstract T cells play an important role in adaptive immunity. An enormous clonal diversity of T-cells with a different specificity, encoded by the T-cell receptor (TCR), protect the body against infection. Most TCR β chains are generated from a V-, D-, and J-segment during recombination in the thymus. Although complete absence of the D-segment is not easily detectable from sequencing data, we find convincing evidence for a substantial proportion of TCR β rearrangements lacking a D-segment. Additionally, sequences without a D-segment are more likely to be abundant within individuals and/or shared between individuals. We find that such sequences are preferentially generated during fetal development and persist within the elderly. Summarizing, TCR β rearrangements without a D-segment are not uncommon, and tend to allow for TCR β chains with a high abundance in the naive repertoire." @default.
- W3136222580 created "2021-03-29" @default.
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- W3136222580 creator A5059934243 @default.
- W3136222580 date "2021-03-07" @default.
- W3136222580 modified "2023-09-23" @default.
- W3136222580 title "TCRβ rearrangements without D-segment are common, abundant and public" @default.
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- W3136222580 doi "https://doi.org/10.1101/2021.03.05.434088" @default.
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