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- W3136229817 abstract "RNA splicing has been recognized in recent years as a pivotal player in heart development and disease. The Ca 2+ /calmodulin dependent protein kinase II delta (CaMKIIδ) is a multifunctional Ser/Thr kinase family and generates at least 11 different splice variants through alternative splicing. This enzyme, which belongs to the CaMKII family, is the predominant family member in the heart and functions as a messenger toward adaptive or detrimental signaling in cardiomyocytes. Classically, the nuclear CaMKIIδB and cytoplasmic CaMKIIδC splice variants are described as mediators of arrhythmias, contractile function, Ca 2+ handling, and gene transcription. Recent findings also put CaMKIIδA and CaMKIIδ9 as cardinal players in the global CaMKII response in the heart. In this review, we discuss and summarize the new insights into CaMKIIδ splice variants and their (proposed) functions, as well as CaMKII-engineered mouse phenotypes and cardiac dysfunction related to CaMKIIδ missplicing. We also discuss RNA splicing factors affecting CaMKII splicing. Finally, we discuss the translational perspective derived from these insights and future directions on CaMKIIδ splicing research in the healthy and diseased heart." @default.
- W3136229817 created "2021-03-29" @default.
- W3136229817 creator A5012371948 @default.
- W3136229817 creator A5014027497 @default.
- W3136229817 creator A5025526035 @default.
- W3136229817 creator A5037102400 @default.
- W3136229817 creator A5070951638 @default.
- W3136229817 date "2021-03-11" @default.
- W3136229817 modified "2023-10-13" @default.
- W3136229817 title "CaMKIIδ Splice Variants in the Healthy and Diseased Heart" @default.
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