FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136233298> ?p ?o ?g. }

• W3136233298 endingPage "1581" @default.
• W3136233298 startingPage "1581" @default.
• W3136233298 abstract "Spondias mombin L. (Anacardiaceae) has a worldwide distribution and is present in all regions of Brazil. Its leaves, flowers and bark are used as teas in folk medicine to treat diseases of the digestive system. This study aimed to evaluate the acute non-clinical toxicity, gastroprotective activity, and the related mechanisms of action of nebulized extract and tablets based on dried Spondias mombin (SmNE). SmNE screening showed the presence of flavonoids (0.65%), polyphenols (25.50%), where the major compound is gallic acid. In the acute oral toxicity assay, a dose of 2000 mg/kg of SmNE administered orally in Swiss mice did not induce any behavioral changes. SmNE (250 or 500 mg/kg p.o) significantly reduced the ulcerative lesion area when compared to the control group in ethanol and non-steroidal anti-inflammatory drug (NSAIDs) models. Results showed that treatment with SmNE (250 mg/kg) reduced acid secretion and gastric content, accompanied with an increase in pH. Previous administration of indomethacin and glibenclamide reversed the protection provided by SmNE, confirming the participation of prostaglandins (PGs) and ATP-sensitive potassium channels (KATP) in its gastroprotective effect. The SmNE tablets met the pharmacopeial quality requirements with gastroprotective activity and similar protection in comparison to the isolated extract administrated. In conclusion, SmNe has a gastroprotective activity related to cytoprotective mechanisms, such as the participation of endogenous prostaglandins and KATP channels, having an anti-secretory effect with systemic action. The formulation obtained presented gastroprotective effects similar to the administration of the extract, the tablets showed favorable compression characteristics by the direct route and met the pharmacopeial quality requirements." @default.
• W3136233298 created "2021-03-29" @default.
• W3136233298 creator A5015782951 @default.
• W3136233298 creator A5022512395 @default.
• W3136233298 creator A5023080247 @default.
• W3136233298 creator A5039473973 @default.
• W3136233298 creator A5046138976 @default.
• W3136233298 creator A5047323301 @default.
• W3136233298 creator A5056088724 @default.
• W3136233298 creator A5062758801 @default.
• W3136233298 creator A5063233700 @default.
• W3136233298 creator A5083128801 @default.
• W3136233298 creator A5091125194 @default.
• W3136233298 date "2021-03-12" @default.
• W3136233298 modified "2023-10-12" @default.
• W3136233298 title "Tablet of Spondias mombin L. Developed from Nebulized Extract Prevents Gastric Ulcers in Mice via Cytoprotective and Antisecretory Effects" @default.
• W3136233298 cites W1615012936 @default.
• W3136233298 cites W1710578554 @default.
• W3136233298 cites W1964860341 @default.
• W3136233298 cites W1967128906 @default.
• W3136233298 cites W1968867674 @default.
• W3136233298 cites W1971025191 @default.
• W3136233298 cites W1977624075 @default.
• W3136233298 cites W1994977660 @default.
• W3136233298 cites W1995980971 @default.
• W3136233298 cites W2027752180 @default.
• W3136233298 cites W2034331969 @default.
• W3136233298 cites W2034670474 @default.
• W3136233298 cites W2043428504 @default.
• W3136233298 cites W2046132421 @default.
• W3136233298 cites W2055990587 @default.
• W3136233298 cites W2067375914 @default.
• W3136233298 cites W2068036870 @default.
• W3136233298 cites W2077233349 @default.
• W3136233298 cites W2091085343 @default.
• W3136233298 cites W2095154419 @default.
• W3136233298 cites W2095361684 @default.
• W3136233298 cites W2138564499 @default.
• W3136233298 cites W2148387960 @default.
• W3136233298 cites W2193136353 @default.
• W3136233298 cites W2289504447 @default.
• W3136233298 cites W2328179864 @default.
• W3136233298 cites W2539233839 @default.
• W3136233298 cites W2578827620 @default.
• W3136233298 cites W2589049885 @default.
• W3136233298 cites W2614302069 @default.
• W3136233298 cites W2618677665 @default.
• W3136233298 cites W2783519346 @default.
• W3136233298 cites W2789848598 @default.
• W3136233298 cites W2794407160 @default.
• W3136233298 cites W2795031019 @default.
• W3136233298 cites W2801646464 @default.
• W3136233298 cites W2803319696 @default.
• W3136233298 cites W2807130284 @default.
• W3136233298 cites W2886228419 @default.
• W3136233298 cites W2891989250 @default.
• W3136233298 cites W2900098959 @default.
• W3136233298 cites W2904626400 @default.
• W3136233298 cites W2904808565 @default.
• W3136233298 cites W2910414352 @default.
• W3136233298 cites W291126721 @default.
• W3136233298 cites W2950022303 @default.
• W3136233298 cites W2964520233 @default.
• W3136233298 cites W3005085851 @default.
• W3136233298 cites W3035783165 @default.
• W3136233298 cites W3043995542 @default.
• W3136233298 cites W4211029205 @default.
• W3136233298 cites W4255381023 @default.
• W3136233298 cites W561786011 @default.
• W3136233298 doi "https://doi.org/10.3390/molecules26061581" @default.
• W3136233298 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8001497" @default.
• W3136233298 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33809398" @default.
• W3136233298 hasPublicationYear "2021" @default.
• W3136233298 type Work @default.
• W3136233298 sameAs 3136233298 @default.
• W3136233298 citedByCount "4" @default.
• W3136233298 countsByYear W31362332982022 @default.
• W3136233298 countsByYear W31362332982023 @default.
• W3136233298 crossrefType "journal-article" @default.
• W3136233298 hasAuthorship W3136233298A5015782951 @default.
• W3136233298 hasAuthorship W3136233298A5022512395 @default.
• W3136233298 hasAuthorship W3136233298A5023080247 @default.
• W3136233298 hasAuthorship W3136233298A5039473973 @default.
• W3136233298 hasAuthorship W3136233298A5046138976 @default.
• W3136233298 hasAuthorship W3136233298A5047323301 @default.
• W3136233298 hasAuthorship W3136233298A5056088724 @default.
• W3136233298 hasAuthorship W3136233298A5062758801 @default.
• W3136233298 hasAuthorship W3136233298A5063233700 @default.
• W3136233298 hasAuthorship W3136233298A5083128801 @default.
• W3136233298 hasAuthorship W3136233298A5091125194 @default.
• W3136233298 hasBestOaLocation W31362332981 @default.
• W3136233298 hasConcept C116263406 @default.
• W3136233298 hasConcept C126322002 @default.
• W3136233298 hasConcept C134018914 @default.
• W3136233298 hasConcept C185592680 @default.
• W3136233298 hasConcept C2777504413 @default.
• W3136233298 hasConcept C2778004101 @default.
• W3136233298 hasConcept C2778229996 @default.

• next