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- W3136237345 endingPage "569" @default.
- W3136237345 startingPage "569" @default.
- W3136237345 abstract "Taxanes, mainly paclitaxel and docetaxel, the microtubule stabilizers, have been well known for being the first-line therapy for breast cancer for more than the last thirty years. Moreover, they have been also used for the treatment of ovarian, hormone-refractory prostate, head and neck, and non-small cell lung carcinomas. Even though paclitaxel and docetaxel significantly enhance the overall survival rate of cancer patients, there are some limitations of their use, such as very poor water solubility and the occurrence of severe side effects. However, this is what pushes the research on these microtubule-stabilizing agents further and yields novel taxane derivatives with significantly improved properties. Therefore, this review article brings recent advances reported in taxane research mainly in the last two years. We focused especially on recent methods of taxane isolation, their mechanism of action, development of their novel derivatives, formulations, and improved tumor-targeted drug delivery. Since cancer cell chemoresistance can be an unsurpassable hurdle in taxane administration, a significant part of this review article has been also devoted to combination therapy of taxanes in cancer treatment. Last but not least, we summarize ongoing clinical trials on these compounds and bring a perspective of advancements in this field." @default.
- W3136237345 created "2021-03-29" @default.
- W3136237345 creator A5016599264 @default.
- W3136237345 creator A5053416580 @default.
- W3136237345 creator A5057667007 @default.
- W3136237345 creator A5071608209 @default.
- W3136237345 date "2021-03-17" @default.
- W3136237345 modified "2023-10-02" @default.
- W3136237345 title "Current Perspectives on Taxanes: Focus on Their Bioactivity, Delivery and Combination Therapy" @default.
- W3136237345 cites W1824230505 @default.
- W3136237345 cites W1898909764 @default.
- W3136237345 cites W1963526834 @default.
- W3136237345 cites W1965332656 @default.
- W3136237345 cites W1965380784 @default.
- W3136237345 cites W1966647123 @default.
- W3136237345 cites W1969651345 @default.
- W3136237345 cites W1971802375 @default.
- W3136237345 cites W1972439846 @default.
- W3136237345 cites W1973616673 @default.
- W3136237345 cites W1975688780 @default.
- W3136237345 cites W1978932462 @default.
- W3136237345 cites W1981520711 @default.
- W3136237345 cites W1981686319 @default.
- W3136237345 cites W1981771754 @default.
- W3136237345 cites W1983326831 @default.
- W3136237345 cites W1993054253 @default.
- W3136237345 cites W1994471384 @default.
- W3136237345 cites W1995829772 @default.
- W3136237345 cites W1998240064 @default.
- W3136237345 cites W2004131109 @default.
- W3136237345 cites W2004202173 @default.
- W3136237345 cites W2005296909 @default.
- W3136237345 cites W2006367732 @default.
- W3136237345 cites W2014184691 @default.
- W3136237345 cites W2024542936 @default.
- W3136237345 cites W2026450209 @default.
- W3136237345 cites W2028862921 @default.
- W3136237345 cites W2030557341 @default.
- W3136237345 cites W2032621729 @default.
- W3136237345 cites W2037490361 @default.
- W3136237345 cites W2040007514 @default.
- W3136237345 cites W2056966352 @default.
- W3136237345 cites W2061460215 @default.
- W3136237345 cites W2063796329 @default.
- W3136237345 cites W2063825168 @default.
- W3136237345 cites W2067299834 @default.
- W3136237345 cites W2069239609 @default.
- W3136237345 cites W2069348059 @default.
- W3136237345 cites W2074962628 @default.
- W3136237345 cites W2076847707 @default.
- W3136237345 cites W2077246806 @default.
- W3136237345 cites W2077920079 @default.
- W3136237345 cites W2083226227 @default.
- W3136237345 cites W2087011085 @default.
- W3136237345 cites W2091691633 @default.
- W3136237345 cites W2111237964 @default.
- W3136237345 cites W2112270137 @default.
- W3136237345 cites W2114767132 @default.
- W3136237345 cites W2115733082 @default.
- W3136237345 cites W2125356639 @default.
- W3136237345 cites W2125558775 @default.
- W3136237345 cites W2129707741 @default.
- W3136237345 cites W2130252520 @default.
- W3136237345 cites W2135440815 @default.
- W3136237345 cites W2135953831 @default.
- W3136237345 cites W2138473858 @default.
- W3136237345 cites W2139697170 @default.
- W3136237345 cites W2142042045 @default.
- W3136237345 cites W2142504874 @default.
- W3136237345 cites W2143708956 @default.
- W3136237345 cites W2145555831 @default.
- W3136237345 cites W2147799947 @default.
- W3136237345 cites W2153837875 @default.
- W3136237345 cites W2154241215 @default.
- W3136237345 cites W2154546143 @default.
- W3136237345 cites W2154673624 @default.
- W3136237345 cites W2159074577 @default.
- W3136237345 cites W2160516150 @default.
- W3136237345 cites W2162724777 @default.
- W3136237345 cites W2165480504 @default.
- W3136237345 cites W2166699788 @default.
- W3136237345 cites W2168059482 @default.
- W3136237345 cites W2168323912 @default.
- W3136237345 cites W2171640937 @default.
- W3136237345 cites W2174474248 @default.
- W3136237345 cites W2184694295 @default.
- W3136237345 cites W2302518824 @default.
- W3136237345 cites W2316974258 @default.
- W3136237345 cites W2327087246 @default.
- W3136237345 cites W2397403839 @default.
- W3136237345 cites W2417502812 @default.
- W3136237345 cites W2419112278 @default.
- W3136237345 cites W2426716710 @default.
- W3136237345 cites W2537173072 @default.
- W3136237345 cites W2541859010 @default.
- W3136237345 cites W2564217539 @default.
- W3136237345 cites W2568910747 @default.
- W3136237345 cites W2579340176 @default.