FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136238762> ?p ?o ?g. }

• W3136238762 endingPage "1565" @default.
• W3136238762 startingPage "1554" @default.
• W3136238762 abstract "The clinical effects of remimazolam (an investigational, ultra-short acting benzodiazepine being studied in procedural sedation) were measured using the Modified Observer's Assessment of Awareness/Sedation Scale (MOAA/S). The objective of this analysis was to develop a population pharmacokinetic/pharmacodynamic model to describe remimazolam-induced sedation with fentanyl over time in procedural sedation. MOAA/S from 10 clinical phase I-III trials were pooled for analysis, where data were collected after administration of placebo or remimazolam with or without concomitant fentanyl. A Markov model described transition states for 35,356 MOAA/S-time observations from 1071 subjects. Effect-compartment models of remimazolam and fentanyl linked plasma concentrations to the Markov model, and drug effects were described using a synergistic maximum effect (Emax ) model. Simulations were performed to identify the optimal remimazolam-fentanyl combination doses in procedural sedation. Fentanyl showed synergistic effects with remimazolam in sedation. Increasing age was related to longer recovery from sedation. Patients with body mass index greater than 25 kg/m2 had ~30% higher rates of distribution from plasma to the effect site (keo), indicating a slightly faster onset of sedation. Simulations showed that remimazolam 5 mg was more appropriate than 4 or 6 mg when administered with fentanyl 50 μg. The model and simulations support that a combination of remimazolam 5 mg with fentanyl 50 μg is an appropriate dosing regimen and the dose of remimazolam does not need to be changed in elderly patients, but some elderly patients may have a longer duration of sedation." @default.
• W3136238762 created "2021-03-29" @default.
• W3136238762 creator A5000141938 @default.
• W3136238762 creator A5001031173 @default.
• W3136238762 creator A5047536675 @default.
• W3136238762 creator A5051529179 @default.
• W3136238762 creator A5058171391 @default.
• W3136238762 creator A5070117385 @default.
• W3136238762 creator A5071647679 @default.
• W3136238762 creator A5072792871 @default.
• W3136238762 date "2021-04-09" @default.
• W3136238762 modified "2023-09-26" @default.
• W3136238762 title "A population pharmacodynamic Markov mixed‐effects model for determining remimazolam‐induced sedation when co‐administered with fentanyl in procedural sedation" @default.
• W3136238762 cites W123609371 @default.
• W3136238762 cites W1880720469 @default.
• W3136238762 cites W1968482673 @default.
• W3136238762 cites W1972768441 @default.
• W3136238762 cites W1977462728 @default.
• W3136238762 cites W2011741504 @default.
• W3136238762 cites W2023078573 @default.
• W3136238762 cites W2066334362 @default.
• W3136238762 cites W2091787052 @default.
• W3136238762 cites W2104814996 @default.
• W3136238762 cites W2106814980 @default.
• W3136238762 cites W2139255073 @default.
• W3136238762 cites W2324227497 @default.
• W3136238762 cites W2324884202 @default.
• W3136238762 cites W2656350344 @default.
• W3136238762 cites W2799631170 @default.
• W3136238762 cites W2894718719 @default.
• W3136238762 cites W2901633965 @default.
• W3136238762 cites W2929003467 @default.
• W3136238762 cites W2998786011 @default.
• W3136238762 cites W3037769245 @default.
• W3136238762 cites W3092196027 @default.
• W3136238762 cites W4248644417 @default.
• W3136238762 cites W4253801918 @default.
• W3136238762 cites W4254475860 @default.
• W3136238762 doi "https://doi.org/10.1111/cts.13023" @default.
• W3136238762 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8301564" @default.
• W3136238762 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33768731" @default.
• W3136238762 hasPublicationYear "2021" @default.
• W3136238762 type Work @default.
• W3136238762 sameAs 3136238762 @default.
• W3136238762 citedByCount "9" @default.
• W3136238762 countsByYear W31362387622021 @default.
• W3136238762 countsByYear W31362387622022 @default.
• W3136238762 countsByYear W31362387622023 @default.
• W3136238762 crossrefType "journal-article" @default.
• W3136238762 hasAuthorship W3136238762A5000141938 @default.
• W3136238762 hasAuthorship W3136238762A5001031173 @default.
• W3136238762 hasAuthorship W3136238762A5047536675 @default.
• W3136238762 hasAuthorship W3136238762A5051529179 @default.
• W3136238762 hasAuthorship W3136238762A5058171391 @default.
• W3136238762 hasAuthorship W3136238762A5070117385 @default.
• W3136238762 hasAuthorship W3136238762A5071647679 @default.
• W3136238762 hasAuthorship W3136238762A5072792871 @default.
• W3136238762 hasBestOaLocation W31362387621 @default.
• W3136238762 hasConcept C111113717 @default.
• W3136238762 hasConcept C112705442 @default.
• W3136238762 hasConcept C126322002 @default.
• W3136238762 hasConcept C170493617 @default.
• W3136238762 hasConcept C197934379 @default.
• W3136238762 hasConcept C2776239304 @default.
• W3136238762 hasConcept C2776814716 @default.
• W3136238762 hasConcept C2777288759 @default.
• W3136238762 hasConcept C2778173252 @default.
• W3136238762 hasConcept C2778375690 @default.
• W3136238762 hasConcept C2781072394 @default.
• W3136238762 hasConcept C2908647359 @default.
• W3136238762 hasConcept C42219234 @default.
• W3136238762 hasConcept C71924100 @default.
• W3136238762 hasConcept C98274493 @default.
• W3136238762 hasConcept C99454951 @default.
• W3136238762 hasConceptScore W3136238762C111113717 @default.
• W3136238762 hasConceptScore W3136238762C112705442 @default.
• W3136238762 hasConceptScore W3136238762C126322002 @default.
• W3136238762 hasConceptScore W3136238762C170493617 @default.
• W3136238762 hasConceptScore W3136238762C197934379 @default.
• W3136238762 hasConceptScore W3136238762C2776239304 @default.
• W3136238762 hasConceptScore W3136238762C2776814716 @default.
• W3136238762 hasConceptScore W3136238762C2777288759 @default.
• W3136238762 hasConceptScore W3136238762C2778173252 @default.
• W3136238762 hasConceptScore W3136238762C2778375690 @default.
• W3136238762 hasConceptScore W3136238762C2781072394 @default.
• W3136238762 hasConceptScore W3136238762C2908647359 @default.
• W3136238762 hasConceptScore W3136238762C42219234 @default.
• W3136238762 hasConceptScore W3136238762C71924100 @default.
• W3136238762 hasConceptScore W3136238762C98274493 @default.
• W3136238762 hasConceptScore W3136238762C99454951 @default.
• W3136238762 hasIssue "4" @default.
• W3136238762 hasLocation W31362387621 @default.
• W3136238762 hasLocation W31362387622 @default.
• W3136238762 hasLocation W31362387623 @default.
• W3136238762 hasOpenAccess W3136238762 @default.
• W3136238762 hasPrimaryLocation W31362387621 @default.
• W3136238762 hasRelatedWork W1774015459 @default.
• W3136238762 hasRelatedWork W2018245099 @default.

• next