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- W3136241758 endingPage "3238" @default.
- W3136241758 startingPage "3238" @default.
- W3136241758 abstract "The ductus arteriosus (DA) is a physiologic vessel crucial for fetal circulation. As a major regulating factor, the prostaglandin pathway has long been the target for DA patency maintenance or closure. However, the adverse effect of prostaglandins and their inhibitors has been a major unsolved clinical problem. Furthermore, a significant portion of patients with patent DA fail to respond to cyclooxygenase inhibitors that target the prostaglandin pathway. These unresponsive medical patients ultimately require surgical intervention and highlight the importance of exploring pathways independent from this well-recognized prostaglandin pathway. The clinical limitations of prostaglandin-targeting therapeutics prompted us to investigate molecules beyond the prostaglandin pathway. Thus, this article introduces molecules independent from the prostaglandin pathway based on their correlating mechanisms contributing to vascular remodeling. These molecules may serve as potential targets for future DA patency clinical management." @default.
- W3136241758 created "2021-03-29" @default.
- W3136241758 creator A5007695335 @default.
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- W3136241758 creator A5062817352 @default.
- W3136241758 creator A5075838887 @default.
- W3136241758 creator A5080479396 @default.
- W3136241758 date "2021-03-22" @default.
- W3136241758 modified "2023-10-17" @default.
- W3136241758 title "Molecular Mechanisms Underlying Remodeling of Ductus Arteriosus: Looking beyond the Prostaglandin Pathway" @default.
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