Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136243689> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W3136243689 abstract "The enteric nervous system mediates reflexes independently of the brain and spinal cord and transmits signals bidirectionally between the gut and the brain. Hirschsprung disease and chronic intestinal pseudo-obstruction (CIPO) and pediatric CIPO are examples of congenital defects that impair gastrointestinal motility. In this issue of the JCI, Thuy-Linh Le et al. analyzed eight patients with defects in tissue that arose from the neural crest. The patients carried homozygous or heterozygous variants in ERBB3 or ERBB2, which encode transmembrane epidermal growth factor receptors that bind neuroregulin 1 (NRG1). Notably, the genetic variants resulted in loss of function with decreased expression or aberrant phosphorylation of the ERBB3/ERBB2 receptors. Experiments using mice revealed that Erbb3 and Erbb2 were expressed in enteric neuronal progenitor cells. This study is an outstanding example of descriptive observation that begs for mechanistic exploration to reveal precisely how the NRG1/ERBB3/ERBB2 pathway influences ENS development." @default.
- W3136243689 created "2021-03-29" @default.
- W3136243689 creator A5019329770 @default.
- W3136243689 date "2021-03-15" @default.
- W3136243689 modified "2023-09-25" @default.
- W3136243689 title "Hirschsprung disease and more: dysregulation of ERBB2 and ERBB3" @default.
- W3136243689 cites W1979816705 @default.
- W3136243689 cites W1995242599 @default.
- W3136243689 cites W1999693507 @default.
- W3136243689 cites W2018139276 @default.
- W3136243689 cites W2062423918 @default.
- W3136243689 cites W2074170762 @default.
- W3136243689 cites W2090138483 @default.
- W3136243689 cites W2130583261 @default.
- W3136243689 cites W2344695725 @default.
- W3136243689 cites W2403600548 @default.
- W3136243689 cites W2462422777 @default.
- W3136243689 cites W2580725893 @default.
- W3136243689 cites W2765346006 @default.
- W3136243689 cites W2773637439 @default.
- W3136243689 cites W2781721033 @default.
- W3136243689 cites W2793031757 @default.
- W3136243689 cites W2804121313 @default.
- W3136243689 cites W2884568348 @default.
- W3136243689 cites W2900267843 @default.
- W3136243689 cites W3007341505 @default.
- W3136243689 cites W3043972565 @default.
- W3136243689 cites W3098708750 @default.
- W3136243689 cites W3106465851 @default.
- W3136243689 cites W3122105450 @default.
- W3136243689 doi "https://doi.org/10.1172/jci146389" @default.
- W3136243689 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7954584" @default.
- W3136243689 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33720042" @default.
- W3136243689 hasPublicationYear "2021" @default.
- W3136243689 type Work @default.
- W3136243689 sameAs 3136243689 @default.
- W3136243689 citedByCount "3" @default.
- W3136243689 countsByYear W31362436892022 @default.
- W3136243689 countsByYear W31362436892023 @default.
- W3136243689 crossrefType "journal-article" @default.
- W3136243689 hasAuthorship W3136243689A5019329770 @default.
- W3136243689 hasBestOaLocation W31362436891 @default.
- W3136243689 hasConcept C101544691 @default.
- W3136243689 hasConcept C104317684 @default.
- W3136243689 hasConcept C115456853 @default.
- W3136243689 hasConcept C126322002 @default.
- W3136243689 hasConcept C126749454 @default.
- W3136243689 hasConcept C169760540 @default.
- W3136243689 hasConcept C170493617 @default.
- W3136243689 hasConcept C24530287 @default.
- W3136243689 hasConcept C2777439022 @default.
- W3136243689 hasConcept C2779089422 @default.
- W3136243689 hasConcept C2779134260 @default.
- W3136243689 hasConcept C2779438470 @default.
- W3136243689 hasConcept C2780943970 @default.
- W3136243689 hasConcept C54355233 @default.
- W3136243689 hasConcept C71924100 @default.
- W3136243689 hasConcept C86803240 @default.
- W3136243689 hasConceptScore W3136243689C101544691 @default.
- W3136243689 hasConceptScore W3136243689C104317684 @default.
- W3136243689 hasConceptScore W3136243689C115456853 @default.
- W3136243689 hasConceptScore W3136243689C126322002 @default.
- W3136243689 hasConceptScore W3136243689C126749454 @default.
- W3136243689 hasConceptScore W3136243689C169760540 @default.
- W3136243689 hasConceptScore W3136243689C170493617 @default.
- W3136243689 hasConceptScore W3136243689C24530287 @default.
- W3136243689 hasConceptScore W3136243689C2777439022 @default.
- W3136243689 hasConceptScore W3136243689C2779089422 @default.
- W3136243689 hasConceptScore W3136243689C2779134260 @default.
- W3136243689 hasConceptScore W3136243689C2779438470 @default.
- W3136243689 hasConceptScore W3136243689C2780943970 @default.
- W3136243689 hasConceptScore W3136243689C54355233 @default.
- W3136243689 hasConceptScore W3136243689C71924100 @default.
- W3136243689 hasConceptScore W3136243689C86803240 @default.
- W3136243689 hasIssue "6" @default.
- W3136243689 hasLocation W31362436891 @default.
- W3136243689 hasLocation W31362436892 @default.
- W3136243689 hasLocation W31362436893 @default.
- W3136243689 hasOpenAccess W3136243689 @default.
- W3136243689 hasPrimaryLocation W31362436891 @default.
- W3136243689 hasRelatedWork W2044599321 @default.
- W3136243689 hasRelatedWork W2189641654 @default.
- W3136243689 hasRelatedWork W2917540868 @default.
- W3136243689 hasRelatedWork W2995891640 @default.
- W3136243689 hasRelatedWork W3030781247 @default.
- W3136243689 hasRelatedWork W3031276132 @default.
- W3136243689 hasRelatedWork W3098708750 @default.
- W3136243689 hasRelatedWork W3136243689 @default.
- W3136243689 hasRelatedWork W4200529709 @default.
- W3136243689 hasRelatedWork W4238836850 @default.
- W3136243689 hasVolume "131" @default.
- W3136243689 isParatext "false" @default.
- W3136243689 isRetracted "false" @default.
- W3136243689 magId "3136243689" @default.
- W3136243689 workType "article" @default.