FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136245304> ?p ?o ?g. }

• W3136245304 abstract "Abstract Background Diesel exhaust (DE) is a major source of ultrafine particulate matters (PM) in ambient air and contaminates many occupational settings. Airway remodeling assessed using computerized tomography (CT) correlates well with spirometry in patients with obstructive lung diseases. Structural changes of small airways caused by chronic DE exposure is unknown. Wall and lumen areas of 6th and 9th generations of four candidate airways were quantified using end-inhalation CT scans in 78 diesel engine testers (DET) and 76 non-DETs. Carbon content in airway macrophage (CCAM) in sputum was quantified to assess the dose-response relationship. Results Environmental monitoring and CCAM showed a much higher PM exposure in DETs, which was associated with higher wall area and wall area percent for 6th generation of airways. However, no reduction in lumen area was identified. No study subjects met spirometry diagnosis of airway obstruction. This suggested that small airway wall thickening without lumen narrowing may be an early feature of airway remodeling in DETs. The effect of DE exposure status on wall area percent did not differ by lobes or smoking status. Although the trend test was of borderline significance between categorized CCAM and wall area percent, subjects in the highest CCAM category has a 14% increase in wall area percent for the 6th generation of airways compared to subjects in the lowest category. The impact of DE exposure on FEV1 can be partially explained by the wall area percent with mediation effect size equal to 20%, P perm = 0.028). Conclusions Small airway wall thickening without lumen narrowing may be an early image feature detected by CT and underlie the pathology of lung injury in DETs. The pattern of changes in small airway dimensions, i.e., thicker airway wall without lumen narrowing caused by occupational DE exposure was different to that (i.e., thicker airway wall with lumen narrowing) seen in our previous study of workers exposed to nano-scale carbon black aerosol, suggesting constituents other than carbon cores may contribute to such differences. Our study provides some imaging indications of the understanding of the pulmonary toxicity of combustion derived airborne particulate matters in humans." @default.
• W3136245304 created "2021-03-29" @default.
• W3136245304 creator A5004981927 @default.
• W3136245304 creator A5005024003 @default.
• W3136245304 creator A5009545428 @default.
• W3136245304 creator A5015728065 @default.
• W3136245304 creator A5016519042 @default.
• W3136245304 creator A5017322165 @default.
• W3136245304 creator A5020081483 @default.
• W3136245304 creator A5027304141 @default.
• W3136245304 creator A5063939423 @default.
• W3136245304 creator A5070544831 @default.
• W3136245304 creator A5078501702 @default.
• W3136245304 creator A5086220430 @default.
• W3136245304 creator A5087174100 @default.
• W3136245304 date "2021-03-25" @default.
• W3136245304 modified "2023-10-18" @default.
• W3136245304 title "Chronic exposure to diesel exhaust may cause small airway wall thickening without lumen narrowing: a quantitative computerized tomography study in Chinese diesel engine testers" @default.
• W3136245304 cites W1590928522 @default.
• W3136245304 cites W1970061984 @default.
• W3136245304 cites W1975967622 @default.
• W3136245304 cites W1980157201 @default.
• W3136245304 cites W1982413607 @default.
• W3136245304 cites W1996317186 @default.
• W3136245304 cites W2012814663 @default.
• W3136245304 cites W2024481637 @default.
• W3136245304 cites W2024812229 @default.
• W3136245304 cites W2029924301 @default.
• W3136245304 cites W2030159044 @default.
• W3136245304 cites W2031692081 @default.
• W3136245304 cites W2034050702 @default.
• W3136245304 cites W2039190990 @default.
• W3136245304 cites W2045403114 @default.
• W3136245304 cites W2047673861 @default.
• W3136245304 cites W2050032399 @default.
• W3136245304 cites W2054797095 @default.
• W3136245304 cites W2061934487 @default.
• W3136245304 cites W2064191532 @default.
• W3136245304 cites W2083386295 @default.
• W3136245304 cites W2104102499 @default.
• W3136245304 cites W2125078269 @default.
• W3136245304 cites W2162143838 @default.
• W3136245304 cites W2253509854 @default.
• W3136245304 cites W2335677497 @default.
• W3136245304 cites W2340761766 @default.
• W3136245304 cites W2345443494 @default.
• W3136245304 cites W2353599515 @default.
• W3136245304 cites W2464776310 @default.
• W3136245304 cites W2524395181 @default.
• W3136245304 cites W2586282709 @default.
• W3136245304 cites W2742986910 @default.
• W3136245304 cites W2753087220 @default.
• W3136245304 cites W2769610896 @default.
• W3136245304 cites W2801196222 @default.
• W3136245304 cites W2808920220 @default.
• W3136245304 cites W2809910902 @default.
• W3136245304 cites W2890719012 @default.
• W3136245304 cites W2895970929 @default.
• W3136245304 cites W2943410956 @default.
• W3136245304 cites W2951448719 @default.
• W3136245304 cites W2971390225 @default.
• W3136245304 cites W2972725469 @default.
• W3136245304 cites W3007247612 @default.
• W3136245304 cites W3010323214 @default.
• W3136245304 cites W3019837978 @default.
• W3136245304 cites W3081341692 @default.
• W3136245304 cites W95548685 @default.
• W3136245304 doi "https://doi.org/10.1186/s12989-021-00406-1" @default.
• W3136245304 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7992811" @default.
• W3136245304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33766066" @default.
• W3136245304 hasPublicationYear "2021" @default.
• W3136245304 type Work @default.
• W3136245304 sameAs 3136245304 @default.
• W3136245304 citedByCount "9" @default.
• W3136245304 countsByYear W31362453042021 @default.
• W3136245304 countsByYear W31362453042022 @default.
• W3136245304 countsByYear W31362453042023 @default.
• W3136245304 crossrefType "journal-article" @default.
• W3136245304 hasAuthorship W3136245304A5004981927 @default.
• W3136245304 hasAuthorship W3136245304A5005024003 @default.
• W3136245304 hasAuthorship W3136245304A5009545428 @default.
• W3136245304 hasAuthorship W3136245304A5015728065 @default.
• W3136245304 hasAuthorship W3136245304A5016519042 @default.
• W3136245304 hasAuthorship W3136245304A5017322165 @default.
• W3136245304 hasAuthorship W3136245304A5020081483 @default.
• W3136245304 hasAuthorship W3136245304A5027304141 @default.
• W3136245304 hasAuthorship W3136245304A5063939423 @default.
• W3136245304 hasAuthorship W3136245304A5070544831 @default.
• W3136245304 hasAuthorship W3136245304A5078501702 @default.
• W3136245304 hasAuthorship W3136245304A5086220430 @default.
• W3136245304 hasAuthorship W3136245304A5087174100 @default.
• W3136245304 hasBestOaLocation W31362453041 @default.
• W3136245304 hasConcept C105922876 @default.
• W3136245304 hasConcept C126322002 @default.
• W3136245304 hasConcept C126348684 @default.
• W3136245304 hasConcept C126838900 @default.
• W3136245304 hasConcept C131631996 @default.
• W3136245304 hasConcept C192562407 @default.
• W3136245304 hasConcept C2776042228 @default.
• W3136245304 hasConcept C2778333281 @default.

• next