Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136246084> ?p ?o ?g. }
- W3136246084 endingPage "e202000903" @default.
- W3136246084 startingPage "e202000903" @default.
- W3136246084 abstract "Citrate is important for lipid synthesis and epigenetic regulation in addition to ATP production. We have previously reported that cancer cells import extracellular citrate via the pmCiC transporter to support their metabolism. Here, we show for the first time that citrate is supplied to cancer by cancer-associated stroma (CAS) and also that citrate synthesis and release is one of the latter’s major metabolic tasks. Citrate release from CAS is controlled by cancer cells through cross-cellular communication. The availability of citrate from CAS regulated the cytokine profile, metabolism and features of cellular invasion. Moreover, citrate released by CAS is involved in inducing cancer progression especially enhancing invasiveness and organ colonisation. In line with the in vitro observations, we show that depriving cancer cells of citrate using gluconate, a specific inhibitor of pmCiC, significantly reduced the growth and metastatic spread of human pancreatic cancer cells in vivo and muted stromal activation and angiogenesis. We conclude that citrate is supplied to tumour cells by CAS and citrate uptake plays a significant role in cancer metastatic progression." @default.
- W3136246084 created "2021-03-29" @default.
- W3136246084 creator A5000780752 @default.
- W3136246084 creator A5002864135 @default.
- W3136246084 creator A5003816815 @default.
- W3136246084 creator A5004858139 @default.
- W3136246084 creator A5006654090 @default.
- W3136246084 creator A5008812360 @default.
- W3136246084 creator A5011094627 @default.
- W3136246084 creator A5016829536 @default.
- W3136246084 creator A5017065613 @default.
- W3136246084 creator A5021220228 @default.
- W3136246084 creator A5022464374 @default.
- W3136246084 creator A5023254017 @default.
- W3136246084 creator A5024466490 @default.
- W3136246084 creator A5025256131 @default.
- W3136246084 creator A5029417333 @default.
- W3136246084 creator A5032349242 @default.
- W3136246084 creator A5034364271 @default.
- W3136246084 creator A5036085556 @default.
- W3136246084 creator A5038175354 @default.
- W3136246084 creator A5042333099 @default.
- W3136246084 creator A5042625397 @default.
- W3136246084 creator A5042960013 @default.
- W3136246084 creator A5043305493 @default.
- W3136246084 creator A5050065025 @default.
- W3136246084 creator A5054694861 @default.
- W3136246084 creator A5057974025 @default.
- W3136246084 creator A5061627231 @default.
- W3136246084 creator A5066380716 @default.
- W3136246084 creator A5069368634 @default.
- W3136246084 creator A5072142990 @default.
- W3136246084 creator A5076332139 @default.
- W3136246084 creator A5079611323 @default.
- W3136246084 creator A5083485926 @default.
- W3136246084 creator A5083749444 @default.
- W3136246084 date "2021-03-23" @default.
- W3136246084 modified "2023-10-01" @default.
- W3136246084 title "Cancer-associated cells release citrate to support tumour metastatic progression" @default.
- W3136246084 cites W1598634526 @default.
- W3136246084 cites W1884221296 @default.
- W3136246084 cites W1973387776 @default.
- W3136246084 cites W1988211561 @default.
- W3136246084 cites W1992588796 @default.
- W3136246084 cites W1992742879 @default.
- W3136246084 cites W1997596656 @default.
- W3136246084 cites W2002535198 @default.
- W3136246084 cites W2009308067 @default.
- W3136246084 cites W2009663080 @default.
- W3136246084 cites W2014537925 @default.
- W3136246084 cites W2022899908 @default.
- W3136246084 cites W2025562467 @default.
- W3136246084 cites W2030797581 @default.
- W3136246084 cites W2032058847 @default.
- W3136246084 cites W2045452720 @default.
- W3136246084 cites W2045950965 @default.
- W3136246084 cites W2046320949 @default.
- W3136246084 cites W2047703873 @default.
- W3136246084 cites W2072420502 @default.
- W3136246084 cites W2076272449 @default.
- W3136246084 cites W2078253053 @default.
- W3136246084 cites W2086641174 @default.
- W3136246084 cites W2086906563 @default.
- W3136246084 cites W2104992367 @default.
- W3136246084 cites W2116516144 @default.
- W3136246084 cites W2119390955 @default.
- W3136246084 cites W2124835860 @default.
- W3136246084 cites W2133614954 @default.
- W3136246084 cites W2144358114 @default.
- W3136246084 cites W2145063352 @default.
- W3136246084 cites W2151980465 @default.
- W3136246084 cites W2156185100 @default.
- W3136246084 cites W2162647319 @default.
- W3136246084 cites W2167376541 @default.
- W3136246084 cites W2194585050 @default.
- W3136246084 cites W2264300658 @default.
- W3136246084 cites W2313363788 @default.
- W3136246084 cites W2313646508 @default.
- W3136246084 cites W2396342174 @default.
- W3136246084 cites W2516958665 @default.
- W3136246084 cites W2520035938 @default.
- W3136246084 cites W2561691830 @default.
- W3136246084 cites W2564148647 @default.
- W3136246084 cites W2574419669 @default.
- W3136246084 cites W2606111706 @default.
- W3136246084 cites W2626568439 @default.
- W3136246084 cites W2698350175 @default.
- W3136246084 cites W2729786544 @default.
- W3136246084 cites W2783188990 @default.
- W3136246084 cites W2790490049 @default.
- W3136246084 cites W2796692417 @default.
- W3136246084 cites W2894350935 @default.
- W3136246084 cites W2894776217 @default.
- W3136246084 cites W2898221831 @default.
- W3136246084 cites W2899043276 @default.
- W3136246084 cites W2901386374 @default.
- W3136246084 cites W2901466105 @default.
- W3136246084 cites W2908691578 @default.