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• W3136247958 abstract "It is long known that inbreeding increases the detrimental effects of recessive sequence variants in Runs of Homozygosity (ROHs). However, although the phenotypic association of ROH has been investigated for a variety of traits, the statistical power of the results often remains limited as a sufficiently high number of cases are available for only a restricted number of traits. In the present study, we aim to analyze the association of runs of homozygosity with the trait in-group ethnic favoritism. This analysis assumes that if ethnic identity is important for an individual, that individual may tend to marry more frequently within their own group and therefore ROH are expected to increase. We hypothesize that an attitude preferring one's own ethnic group may be associated with a stronger tendency of inbreeding and, as a result, with more and longer ROHs. Accordingly, we investigated the association between the attitude to someone's own ethnicity and ROH, using the Wisconsin Longitudinal data (WLS, total N ~ 9000) as discovery data set and the Brisbane Twin data as replication data set (N ~ 8000). We find that both the number as well as the total length of homozygous segments are significantly positively associated with in-group ethnic favoritism, independent of the method used for ROH calculation." @default.
• W3136247958 created "2021-03-29" @default.
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• W3136247958 date "2021-03-16" @default.
• W3136247958 modified "2023-09-25" @default.
• W3136247958 title "Ethnic Identity and Genome Wide Runs of Homozygosity" @default.
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• W3136247958 doi "https://doi.org/10.1007/s10519-021-10053-z" @default.
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