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• W3136251353 endingPage "1775" @default.
• W3136251353 startingPage "1770" @default.
• W3136251353 abstract "Abstract We investigate the anti‐cancer stem cell (CSC) properties of two copper(II) complexes containing 4,7‐diphenyl‐1,10‐phenanthroline and a S , N , X ‐Schiff base ligand, where X=O ( 1 ) or S ( 2 ). Complex 1 was previously reported by us, and is the first metal complex to induce cytotoxic and immunogenic cell death of breast CSCs. Complex 2 is a structural analogue of 1 , where the phenolate moiety (within the Schiff base ligand) is replaced by a thiophenolate group. Complex 2 kills bulk breast cancer cells and breast CSCs in the sub‐micromolar range, with reduced toxicity towards non‐cancerous epithelial breast cells. Remarkably, 2 is over 10‐fold more potent towards breast CSC spheroids than salinomycin (an established anti‐breast CSC agent) and cisplatin (a clinically approved anticancer drug). Complex 2 readily enters breast CSCs, accumulates in the cytosol, and increases intracellular reactive oxygen species (ROS) levels upon short exposure (1 h). The latter is likely to be the mechanism by which 2 induces breast CSC death." @default.
• W3136251353 created "2021-03-29" @default.
• W3136251353 creator A5028049515 @default.
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• W3136251353 date "2021-05-01" @default.
• W3136251353 modified "2023-09-23" @default.
• W3136251353 title "A Cancer Stem Cell Potent Copper(II) Complex with a <i>S</i> , <i>N</i> , <i>S</i> ‐Schiff base Ligand and Bathophenanthroline" @default.
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• W3136251353 doi "https://doi.org/10.1002/ejic.202100125" @default.
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