Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136251384> ?p ?o ?g. }
- W3136251384 endingPage "3633" @default.
- W3136251384 startingPage "3617" @default.
- W3136251384 abstract "Abstract Noncoding RNAs are functional transcripts that are not translated into proteins. They represent the largest portion of the human transcriptome and have been shown to regulate gene expression networks in both physiological and pathological cell conditions. Research in this field has made remarkable progress in the comprehension of how aberrations in noncoding RNA drive relevant disease-associated phenotypes; however, the biological role and mechanism of action of several noncoding RNAs still need full understanding. Besides fulfilling its function through sequence-based mechanisms, RNA can form complex secondary and tertiary structures which allow non-canonical interactions with proteins and/or other nucleic acids. In this context, the presence of G-quadruplexes in microRNAs and long noncoding RNAs is increasingly being reported. This evidence suggests a role for RNA G-quadruplexes in controlling microRNA biogenesis and mediating noncoding RNA interaction with biological partners, thus ultimately regulating gene expression. Here, we review the state of the art of G-quadruplexes in the noncoding transcriptome, with their structural and functional characterization. In light of the existence and further possible development of G-quadruplex binders that modulate G-quadruplex conformation and protein interactions, we also discuss the therapeutic potential of G-quadruplexes as targets to interfere with disease-associated noncoding RNAs." @default.
- W3136251384 created "2021-03-29" @default.
- W3136251384 creator A5031926893 @default.
- W3136251384 creator A5054214075 @default.
- W3136251384 creator A5069115725 @default.
- W3136251384 date "2021-03-15" @default.
- W3136251384 modified "2023-10-17" @default.
- W3136251384 title "Biological relevance and therapeutic potential of G-quadruplex structures in the human noncoding transcriptome" @default.
- W3136251384 cites W114315274 @default.
- W3136251384 cites W144423133 @default.
- W3136251384 cites W1515917266 @default.
- W3136251384 cites W1536340771 @default.
- W3136251384 cites W1793796070 @default.
- W3136251384 cites W1843014747 @default.
- W3136251384 cites W1852268638 @default.
- W3136251384 cites W1857388358 @default.
- W3136251384 cites W1963906441 @default.
- W3136251384 cites W1969234199 @default.
- W3136251384 cites W1972533328 @default.
- W3136251384 cites W1974736226 @default.
- W3136251384 cites W1975202253 @default.
- W3136251384 cites W1975690779 @default.
- W3136251384 cites W1976121383 @default.
- W3136251384 cites W1978502771 @default.
- W3136251384 cites W1986324141 @default.
- W3136251384 cites W1990635146 @default.
- W3136251384 cites W1990763521 @default.
- W3136251384 cites W1991153319 @default.
- W3136251384 cites W1991356247 @default.
- W3136251384 cites W1992845343 @default.
- W3136251384 cites W1993738860 @default.
- W3136251384 cites W1998940503 @default.
- W3136251384 cites W2006247279 @default.
- W3136251384 cites W2006936482 @default.
- W3136251384 cites W2008090633 @default.
- W3136251384 cites W2009351714 @default.
- W3136251384 cites W2011677020 @default.
- W3136251384 cites W2012548206 @default.
- W3136251384 cites W2012758718 @default.
- W3136251384 cites W2013646237 @default.
- W3136251384 cites W2018822137 @default.
- W3136251384 cites W2022188871 @default.
- W3136251384 cites W2025988532 @default.
- W3136251384 cites W2038862787 @default.
- W3136251384 cites W2039247139 @default.
- W3136251384 cites W2043332268 @default.
- W3136251384 cites W2045868610 @default.
- W3136251384 cites W2051282896 @default.
- W3136251384 cites W2053855164 @default.
- W3136251384 cites W2056022631 @default.
- W3136251384 cites W2058880763 @default.
- W3136251384 cites W2060987775 @default.
- W3136251384 cites W2068205741 @default.
- W3136251384 cites W2068332602 @default.
- W3136251384 cites W2068517905 @default.
- W3136251384 cites W2069177506 @default.
- W3136251384 cites W2070777085 @default.
- W3136251384 cites W2077327925 @default.
- W3136251384 cites W2079557738 @default.
- W3136251384 cites W2083543262 @default.
- W3136251384 cites W2084136291 @default.
- W3136251384 cites W2087377443 @default.
- W3136251384 cites W2090196938 @default.
- W3136251384 cites W2090908102 @default.
- W3136251384 cites W2092424765 @default.
- W3136251384 cites W2092467693 @default.
- W3136251384 cites W2096719769 @default.
- W3136251384 cites W2099934271 @default.
- W3136251384 cites W2104029124 @default.
- W3136251384 cites W2104454005 @default.
- W3136251384 cites W2105549148 @default.
- W3136251384 cites W2108763751 @default.
- W3136251384 cites W2112001233 @default.
- W3136251384 cites W2113899452 @default.
- W3136251384 cites W2117559345 @default.
- W3136251384 cites W2121352589 @default.
- W3136251384 cites W2122846880 @default.
- W3136251384 cites W2123107276 @default.
- W3136251384 cites W2123724498 @default.
- W3136251384 cites W2128133969 @default.
- W3136251384 cites W2130652515 @default.
- W3136251384 cites W2131604495 @default.
- W3136251384 cites W2135653355 @default.
- W3136251384 cites W2136991248 @default.
- W3136251384 cites W2137986693 @default.
- W3136251384 cites W2147835141 @default.
- W3136251384 cites W2153268494 @default.
- W3136251384 cites W2157534860 @default.
- W3136251384 cites W2168230240 @default.
- W3136251384 cites W2169152986 @default.
- W3136251384 cites W2171928459 @default.
- W3136251384 cites W2182551009 @default.
- W3136251384 cites W2251277318 @default.
- W3136251384 cites W2251344425 @default.
- W3136251384 cites W2275411324 @default.
- W3136251384 cites W2278089208 @default.
- W3136251384 cites W2280931800 @default.
- W3136251384 cites W2315475605 @default.