FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136255019> ?p ?o ?g. }

• W3136255019 endingPage "275" @default.
• W3136255019 startingPage "271" @default.
• W3136255019 abstract "Understanding the mode of action of antimalarials is central to optimizing their use and the discovery of new therapeutics. Currently used antimalarials belong to a limited series of chemical structures and their mechanisms of action are coutinuously debated. Whereas the involvement of reactive species that in turn kill the parasites sensitive to oxidative stress, is accepted for artemisinins, little is known about the generation of such species in the case of quinolines or hydroxynaphtoquinone. Moreover, the nature of the reactive species involved has never been characterized in Plasmodium-infected erythrocytes. The aim of this work was to determine and elucidate the production of the primary radical, superoxide in Plasmodium-infected erythrocytes treated with artemisinin, dihydroartemisinin, chloroquine and atovaquone, as representatives of three major classes of antimalarials. The intracellular generation of superoxide was quantified by liquid chromatography coupled to mass spectrometry (LC-MS). We demonstrated that artemisinins, atovaquone and to a lesser extent chloroquine, generate significant levels of superoxide radicals in Plasmodium falciparum sensitive strains. More so, the production of superoxide was lowered in chloroquine-resistant strain of Plasmodium treated with chloroquine. These results consolidate the knowledge about the mechanism of action of these different antimalarials and should be taken into consideration in the design of future drugs to fight drug-resistant parasites." @default.
• W3136255019 created "2021-03-29" @default.
• W3136255019 creator A5011423966 @default.
• W3136255019 creator A5020304992 @default.
• W3136255019 creator A5052369247 @default.
• W3136255019 creator A5058607882 @default.
• W3136255019 creator A5089241296 @default.
• W3136255019 creator A5090787157 @default.
• W3136255019 date "2021-05-01" @default.
• W3136255019 modified "2023-10-18" @default.
• W3136255019 title "Superoxide: A major role in the mechanism of action of essential antimalarial drugs" @default.
• W3136255019 cites W1992100479 @default.
• W3136255019 cites W1996331410 @default.
• W3136255019 cites W2007561244 @default.
• W3136255019 cites W2011123938 @default.
• W3136255019 cites W2014726464 @default.
• W3136255019 cites W2017094915 @default.
• W3136255019 cites W2020251171 @default.
• W3136255019 cites W2022857214 @default.
• W3136255019 cites W2023633070 @default.
• W3136255019 cites W2025605230 @default.
• W3136255019 cites W2028945502 @default.
• W3136255019 cites W2031821124 @default.
• W3136255019 cites W2033985665 @default.
• W3136255019 cites W2040450077 @default.
• W3136255019 cites W2041422568 @default.
• W3136255019 cites W2074450319 @default.
• W3136255019 cites W2084340821 @default.
• W3136255019 cites W2089288068 @default.
• W3136255019 cites W2114705206 @default.
• W3136255019 cites W2127729530 @default.
• W3136255019 cites W2133990790 @default.
• W3136255019 cites W2135155264 @default.
• W3136255019 cites W2138215247 @default.
• W3136255019 cites W2169242620 @default.
• W3136255019 cites W2304994032 @default.
• W3136255019 cites W2610425683 @default.
• W3136255019 cites W2761950165 @default.
• W3136255019 cites W2795056143 @default.
• W3136255019 cites W2873198680 @default.
• W3136255019 cites W3021931709 @default.
• W3136255019 cites W3038220334 @default.
• W3136255019 cites W4250817567 @default.
• W3136255019 doi "https://doi.org/10.1016/j.freeradbiomed.2021.03.001" @default.
• W3136255019 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33722628" @default.
• W3136255019 hasPublicationYear "2021" @default.
• W3136255019 type Work @default.
• W3136255019 sameAs 3136255019 @default.
• W3136255019 citedByCount "11" @default.
• W3136255019 countsByYear W31362550192021 @default.
• W3136255019 countsByYear W31362550192022 @default.
• W3136255019 countsByYear W31362550192023 @default.
• W3136255019 crossrefType "journal-article" @default.
• W3136255019 hasAuthorship W3136255019A5011423966 @default.
• W3136255019 hasAuthorship W3136255019A5020304992 @default.
• W3136255019 hasAuthorship W3136255019A5052369247 @default.
• W3136255019 hasAuthorship W3136255019A5058607882 @default.
• W3136255019 hasAuthorship W3136255019A5089241296 @default.
• W3136255019 hasAuthorship W3136255019A5090787157 @default.
• W3136255019 hasBestOaLocation W31362550193 @default.
• W3136255019 hasConcept C121587506 @default.
• W3136255019 hasConcept C181199279 @default.
• W3136255019 hasConcept C185592680 @default.
• W3136255019 hasConcept C202751555 @default.
• W3136255019 hasConcept C203014093 @default.
• W3136255019 hasConcept C2776120307 @default.
• W3136255019 hasConcept C2776120743 @default.
• W3136255019 hasConcept C2777425658 @default.
• W3136255019 hasConcept C2778048844 @default.
• W3136255019 hasConcept C2778371730 @default.
• W3136255019 hasConcept C2779124865 @default.
• W3136255019 hasConcept C2780035454 @default.
• W3136255019 hasConcept C2780795997 @default.
• W3136255019 hasConcept C2781160685 @default.
• W3136255019 hasConcept C55493867 @default.
• W3136255019 hasConcept C86380466 @default.
• W3136255019 hasConcept C86803240 @default.
• W3136255019 hasConcept C98274493 @default.
• W3136255019 hasConceptScore W3136255019C121587506 @default.
• W3136255019 hasConceptScore W3136255019C181199279 @default.
• W3136255019 hasConceptScore W3136255019C185592680 @default.
• W3136255019 hasConceptScore W3136255019C202751555 @default.
• W3136255019 hasConceptScore W3136255019C203014093 @default.
• W3136255019 hasConceptScore W3136255019C2776120307 @default.
• W3136255019 hasConceptScore W3136255019C2776120743 @default.
• W3136255019 hasConceptScore W3136255019C2777425658 @default.
• W3136255019 hasConceptScore W3136255019C2778048844 @default.
• W3136255019 hasConceptScore W3136255019C2778371730 @default.
• W3136255019 hasConceptScore W3136255019C2779124865 @default.
• W3136255019 hasConceptScore W3136255019C2780035454 @default.
• W3136255019 hasConceptScore W3136255019C2780795997 @default.
• W3136255019 hasConceptScore W3136255019C2781160685 @default.
• W3136255019 hasConceptScore W3136255019C55493867 @default.
• W3136255019 hasConceptScore W3136255019C86380466 @default.
• W3136255019 hasConceptScore W3136255019C86803240 @default.
• W3136255019 hasConceptScore W3136255019C98274493 @default.
• W3136255019 hasLocation W31362550191 @default.
• W3136255019 hasLocation W31362550192 @default.

• next