FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136255993> ?p ?o ?g. }

• W3136255993 abstract "Background: Increasing evidence indicates a role for Epstein–Barr virus (EBV) in the pathogenesis of multiple sclerosis (MS). EBV-infected autoreactive B cells might accumulate in the central nervous system because of defective cytotoxic CD8 + T cell immunity. We have previously reported results of a phase I clinical trial of autologous EBV-specific T cell therapy in MS 6 months after treatment. Objective: To investigate longer-term outcomes in MS patients who received autologous EBV-specific T cell therapy. Methods: We assessed participants 2 and 3 years after completion of T cell therapy. Results: We collected data from all 10 treated participants at year 2 and from 9 participants at year 3. No serious treatment-related adverse events were observed. Four participants had at least some sustained clinical improvement at year 2, including reduced fatigue in three participants, and reduced Expanded Disability Status Scale score in two participants. Three participants experienced a sustained improvement in at least some symptoms at year 3. More sustained improvement was associated with higher EBV-specific CD8 + T cell reactivity in the administered T cell product. Conclusion: Autologous EBV-specific T cell therapy is well-tolerated, and some degree of clinical improvement can be sustained for up to 3 years after treatment." @default.
• W3136255993 created "2021-03-29" @default.
• W3136255993 creator A5017030859 @default.
• W3136255993 creator A5034787938 @default.
• W3136255993 creator A5035120364 @default.
• W3136255993 creator A5040784989 @default.
• W3136255993 creator A5043246339 @default.
• W3136255993 creator A5048329822 @default.
• W3136255993 creator A5050308657 @default.
• W3136255993 creator A5050621246 @default.
• W3136255993 creator A5055194023 @default.
• W3136255993 creator A5060832681 @default.
• W3136255993 creator A5072459682 @default.
• W3136255993 creator A5079654300 @default.
• W3136255993 creator A5082206020 @default.
• W3136255993 date "2021-03-15" @default.
• W3136255993 modified "2023-10-18" @default.
• W3136255993 title "Sustained Clinical Improvement in a Subset of Patients With Progressive Multiple Sclerosis Treated With Epstein–Barr Virus-Specific T Cell Therapy" @default.
• W3136255993 cites W1968241846 @default.
• W3136255993 cites W1984168657 @default.
• W3136255993 cites W1989371523 @default.
• W3136255993 cites W1997236586 @default.
• W3136255993 cites W1998258994 @default.
• W3136255993 cites W2013917285 @default.
• W3136255993 cites W2019009797 @default.
• W3136255993 cites W2039297073 @default.
• W3136255993 cites W2043625927 @default.
• W3136255993 cites W2061502684 @default.
• W3136255993 cites W2078229430 @default.
• W3136255993 cites W2081046418 @default.
• W3136255993 cites W2081632246 @default.
• W3136255993 cites W2102957457 @default.
• W3136255993 cites W2112165124 @default.
• W3136255993 cites W2112982280 @default.
• W3136255993 cites W2114242035 @default.
• W3136255993 cites W2114832666 @default.
• W3136255993 cites W2122004881 @default.
• W3136255993 cites W2122545833 @default.
• W3136255993 cites W2145647613 @default.
• W3136255993 cites W2146365990 @default.
• W3136255993 cites W2148959055 @default.
• W3136255993 cites W2149662547 @default.
• W3136255993 cites W2167181885 @default.
• W3136255993 cites W2171347293 @default.
• W3136255993 cites W2326826867 @default.
• W3136255993 cites W2573523343 @default.
• W3136255993 cites W2755169970 @default.
• W3136255993 cites W2786871799 @default.
• W3136255993 cites W2806626937 @default.
• W3136255993 cites W2900501647 @default.
• W3136255993 cites W3021074805 @default.
• W3136255993 doi "https://doi.org/10.3389/fneur.2021.652811" @default.
• W3136255993 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8005645" @default.
• W3136255993 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33790852" @default.
• W3136255993 hasPublicationYear "2021" @default.
• W3136255993 type Work @default.
• W3136255993 sameAs 3136255993 @default.
• W3136255993 citedByCount "16" @default.
• W3136255993 countsByYear W31362559932021 @default.
• W3136255993 countsByYear W31362559932022 @default.
• W3136255993 countsByYear W31362559932023 @default.
• W3136255993 crossrefType "journal-article" @default.
• W3136255993 hasAuthorship W3136255993A5017030859 @default.
• W3136255993 hasAuthorship W3136255993A5034787938 @default.
• W3136255993 hasAuthorship W3136255993A5035120364 @default.
• W3136255993 hasAuthorship W3136255993A5040784989 @default.
• W3136255993 hasAuthorship W3136255993A5043246339 @default.
• W3136255993 hasAuthorship W3136255993A5048329822 @default.
• W3136255993 hasAuthorship W3136255993A5050308657 @default.
• W3136255993 hasAuthorship W3136255993A5050621246 @default.
• W3136255993 hasAuthorship W3136255993A5055194023 @default.
• W3136255993 hasAuthorship W3136255993A5060832681 @default.
• W3136255993 hasAuthorship W3136255993A5072459682 @default.
• W3136255993 hasAuthorship W3136255993A5079654300 @default.
• W3136255993 hasAuthorship W3136255993A5082206020 @default.
• W3136255993 hasBestOaLocation W31362559931 @default.
• W3136255993 hasConcept C10882517 @default.
• W3136255993 hasConcept C126322002 @default.
• W3136255993 hasConcept C143998085 @default.
• W3136255993 hasConcept C1491633281 @default.
• W3136255993 hasConcept C154317977 @default.
• W3136255993 hasConcept C167672396 @default.
• W3136255993 hasConcept C197934379 @default.
• W3136255993 hasConcept C202751555 @default.
• W3136255993 hasConcept C203014093 @default.
• W3136255993 hasConcept C2522874641 @default.
• W3136255993 hasConcept C2776090121 @default.
• W3136255993 hasConcept C2780640218 @default.
• W3136255993 hasConcept C2781375147 @default.
• W3136255993 hasConcept C535046627 @default.
• W3136255993 hasConcept C54355233 @default.
• W3136255993 hasConcept C55493867 @default.
• W3136255993 hasConcept C71924100 @default.
• W3136255993 hasConcept C86803240 @default.
• W3136255993 hasConcept C8891405 @default.
• W3136255993 hasConceptScore W3136255993C10882517 @default.
• W3136255993 hasConceptScore W3136255993C126322002 @default.
• W3136255993 hasConceptScore W3136255993C143998085 @default.
• W3136255993 hasConceptScore W3136255993C1491633281 @default.
• W3136255993 hasConceptScore W3136255993C154317977 @default.

• next