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- W3136257562 endingPage "771" @default.
- W3136257562 startingPage "758" @default.
- W3136257562 abstract "Modified bases act as marks on cellular RNAs so that they can be distinguished from foreign RNAs, reducing innate immune responses to endogenous RNA. In humans, mutations giving reduced levels of one base modification, adenosine-to-inosine deamination, cause a viral infection mimic syndrome, a congenital encephalitis with aberrant interferon induction. These Aicardi-Goutières syndrome 6 mutations affect adenosine deaminase acting on RNA 1 (ADAR1), which generates inosines in endogenous double-stranded (ds)RNA. The inosine base alters dsRNA structure to prevent aberrant activation of antiviral cytosolic helicase RIG-I-like receptors. We review how effects of inosines, ADARs, and other modified bases have been shown to be important in innate immunity and cancer." @default.
- W3136257562 created "2021-03-29" @default.
- W3136257562 creator A5011441992 @default.
- W3136257562 creator A5026340427 @default.
- W3136257562 creator A5030542209 @default.
- W3136257562 creator A5038820770 @default.
- W3136257562 creator A5041660190 @default.
- W3136257562 creator A5064213548 @default.
- W3136257562 date "2021-09-01" @default.
- W3136257562 modified "2023-10-17" @default.
- W3136257562 title "ADAR RNA Modifications, the Epitranscriptome and Innate Immunity" @default.
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